CAS 70209-81-3

Ivermectina B1b

Descrição:

Ivermectina B1b é um composto de lactona macrocíclica que faz parte da família das avermectinas, conhecido principalmente por suas propriedades antiparasitárias. É derivado da fermentação da bactéria do solo Streptomyces avermitilis. Este composto exibe um amplo espectro de atividade contra vários parasitas, incluindo nematoides e artrópodes, tornando-se amplamente utilizado na medicina veterinária e em algumas aplicações humanas. Ivermectina B1b funciona ligando-se a canais de cloreto ativados por glutamato, levando a um aumento da permeabilidade da membrana celular a íons de cloreto, causando, em última análise, paralisia e morte dos parasitas. A substância é tipicamente administrada por via oral ou tópica, dependendo do organismo-alvo. Ivermectina B1b é caracterizado por sua toxicidade relativamente baixa em mamíferos, o que contribui para seu perfil de segurança quando usado adequadamente. No entanto, é essencial aderir às dosagens recomendadas, pois a overdose pode levar a efeitos adversos. Sua eficácia e segurança tornaram-no um componente crítico no controle de infecções parasitárias em animais de produção e humanos.

Fórmula: C₄₇H₇₂O₁₄

InChI: InChI=1S/C47H72O14/c1-24(2)41-27(5)16-17-46(61-41)22-33-19-32(60-46)15-14-26(4)42(25(3)12-11-13-31-23-54-44-39(48)28(6)18-34(45(50)57-33)47(31,44)51)58-38-21-36(53-10)43(30(8)56-38)59-37-20-35(52-9)40(49)29(7)55-37/h11-14,18,24-25,27,29-30,32-44,48-49,51H,15-17,19-23H2,1-10H3/b12-11+,26-14+,31-13+/t25-,27-,29-,30-,32+,33-,34-,35-,36-,37-,38-,39+,40-,41+,42-,43-,44+,46+,47+/m0/s1

Chave InChI: InChIKey=VARHUCVRRNANBD-PVVXTEPVSA-N

SMILES: [C@H](C)(C)[C@H]1O[C@@]2(C[C@@]3(C[C@](O2)(C/C=C(\C)/[C@@H](O[C@H]4C[C@H](OC)[C@@H](O[C@H]5C[C@H](OC)[C@@H](O)[C@H](C)O5)[C@H](C)O4)[C@@H](C)/C=C/C=C\6/[C@@]7(O)[C@](C(=O)O3)(C=C(C)[C@@H](O)[C@]7(OC6)[H])[H])[H])[H])CC[C@@H]1C

Sinónimos:

• (2aE,4E,5'S,6S,6'R,7S,8E,11R,13R,15S,17aR,20R,20aR,20bS)-20,20b-dihydroxy-5',6,8,19-tetramethyl-6'-(1-methylethyl)-17-oxo-3',4',5',6,6',10,11,14,15,17,17a,20,20a,20b-tetradecahydro-2H,7H-spiro[11,15-methanofuro[4,3,2-pq][2,6]benzodioxacyclooctadecine-13,2'-pyran]-7-yl 2,6-dideoxy-4-O-(2,6-dideoxy-3-O-methyl-α-L-ribo-hexopyranosyl)-3-O-methyl-α-L-arabino-hexopyranoside
• (2aE,4E,8E)-(5'S,6S,6'R,7S,11R,13R,15S,17aR,20R,20aR,20bS)-3',4',5',6,6',7,10,11,14,15,17a,20,20a,20b-Tetradecahydro-20,20b-dihydroxy-6'-isopropyl-5',6,8,19-tetramethyl-17-oxospiro(11,15-methano-2H,13H,17H-furo(4,3,2-pq)(2,6)benzodioxacyclooctadecin-13,2'-(2H)pyran)-7-yl 2,6-dideoxy-4-O-(2,6-dideoxy-3-O-methyl-alpha-L-arabino-hexopyranosyl)-3-O-methyl-alpha-L-arabino-hexopyran
• (2aE,4E,8E)-(5'S,6S,6'R,7S,11R,13R,15S,17aR,20R,20aR,20bS)-3',4',5',6,6',7,10,11,14,15,17a,20,20a,20b-Tetradecahydro-20,20b-dihydroxy-6'-isopropyl-5',6,8,19-tetramethyl-17-oxospiro(11,15-methano-2H,13H,17H-furo(4,3,2-pq)(2,6)benzodioxacyclooctadecin-13,2'-(2H)pyran)-7-yl 2,6-dideoxy-4-O-(2,6-dideoxy-3-O-methyl-alpha-L-arabino-hexopyranosyl)-3-O-methyl-alpha-L-arabino-hexopyranoside
• 22,23-Dihydroavermectin B_1b
• 5-O-Demethyl-25-de(1-methylpropyl)-22,23-dihydro-25-(1-methylethyl)avermectin A_1a
• Avermectin A(sub 1a), 5-O-demethyl-25-de(1-methylpropyl)-22,23-dihydro-25-(1-methylethyl)-
• Avermectin A_1a, 5-O-demethyl-25-de(1-methylpropyl)-22,23-dihydro-25-(1-methylethyl)-
• Avermectin H2B1b
• Ivermectin B1b
• Ivermectin B_1b
• Ivermectin component B(sub 1b)
• Spiro[11,15-methano-2H,13H,17H-furo[4,3,2-pq][2,6]benzodioxacyclooctadecin-13,2′-[2H]pyran], avermectin A_1a deriv.
• Unii-0W28Cyi3Tu
• Spiro[11,15-methano-2H,13H,17H-furo[4,3,2-pq][2,6]benzodioxacyclooctadecin-13,2′-[2H]pyran], avermectin A1a deriv.
• 22,23-Dihydroavermectin B1b
• Avermectin A1a, 5-O-demethyl-25-de(1-methylpropyl)-22,23-dihydro-25-(1-methylethyl)-

Ivermectin B1b

CAS: 70209-81-3

Ivermectin B1b, minor antiparasitic, binds to nematode glutamate channels, causing lasting hyperpolarization and paralysis.

Fórmula: C₄₇H₇₂O₁₄

Cor e Forma: Solid

Peso molecular: 861.079

Ref: TM-T37748

Ivermectine B1b

CAS: 70209-81-3

Cor e Forma: Neat

Ref: 04-CA14488007

Ivermectin B1b

CAS: 70209-81-3

Fórmula: C₄₇H₇₂O₁₄

Peso molecular: 861.08

Ref: 4Z-I-077019

Ivermectin B1b

Produto Controlado

CAS: 70209-81-3

Fórmula: C₄₇H₇₂O₁₄

Cor e Forma: Off White

Peso molecular: 861.066

Ref: TR-I940825

22,23-Dihydroavermectin B1b (Ivermectin B1b)

CAS: 70209-81-3

Ivermectin is a drug that belongs to the anthelmintic class of drugs. It is active against roundworms, pinworms, and hookworms. Ivermectin has been shown to have an effect on autoimmune diseases such as multiple sclerosis, systemic lupus erythematosus, and rheumatoid arthritis by inhibiting the inflammatory response. The drug has been shown to inhibit matrix metalloproteinases in vitro and in vivo. The matrix effect is seen when the drug binds to proteins in the blood plasma or tissue matrix, where it inhibits their activity. This inhibition prevents the degradation of collagen, which can lead to tissue damage or renal failure. Ivermectin also binds to striatal dopamine receptors and inhibits dry weight gain in animals infected with Ostertagia ostertagi. Ivermectin is given orally in a single dose of 200 micrograms/kg body weight for treatment of intestinal worms (roundworm,

Fórmula: C₄₇H₇₂O₁₄

Pureza: Min. 95%

Peso molecular: 861.07 g/mol

Ref: 3D-FD177819

Ivermectin B1b

CAS: 70209-81-3

Fórmula: C₄₇H₇₂O₁₄

Peso molecular: 861.08

Ref: ST-EA-CP-I18018