CAS 71-63-6

Digitoxina

Descrição:

Digitoxina é um glicosídeo cardíaco derivado da planta Digitalis purpurea, comumente conhecida como dedaleira. É utilizado principalmente no tratamento de condições cardíacas, particularmente em casos de insuficiência cardíaca e fibrilação atrial, devido à sua capacidade de aumentar a força das contrações cardíacas e regular o ritmo cardíaco. A estrutura química de Digitoxina inclui um núcleo esteroide com um anel de lactona e múltiplos grupos de açúcar, que contribuem para suas propriedades farmacológicas. É lipofílico, permitindo que atravesse facilmente as membranas celulares, e possui uma meia-vida relativamente longa, o que exige monitoramento cuidadoso da dosagem para evitar toxicidade. Os efeitos colaterais comuns incluem distúrbios gastrointestinais, alterações visuais e potenciais arritmias, particularmente em casos de overdose. O mecanismo de ação de Digitoxina envolve a inibição da bomba Na+/K+ ATPase, levando ao aumento dos níveis de cálcio intracelular, o que melhora a contratilidade cardíaca. Devido ao seu estreito índice terapêutico, Digitoxina requer dosagem e monitoramento cuidadosos em ambientes clínicos.

Fórmula: C₄₁H₆₄O₁₃

InChI: InChI=1/C41H64O13/c1-20-36(46)29(42)16-34(49-20)53-38-22(3)51-35(18-31(38)44)54-37-21(2)50-33(17-30(37)43)52-25-8-11-39(4)24(15-25)6-7-28-27(39)9-12-40(5)26(10-13-41(28,40)47)23-14-32(45)48-19-23/h14,20-22,24-31,33-38,42-44,46-47H,6-13,15-19H2,1-5H3/t20-,21-,22-,24-,25+,26-,27?,28?,29+,30+,31+,33+,34+,35+,36-,37-,38-,39+,40-,41+/m1/s1

Chave InChI: InChIKey=WDJUZGPOPHTGOT-XUDUSOBPSA-N

SMILES: O[C@@]12[C@]3([C@@]([C@]4(C)[C@](CC3)(C[C@@H](O[C@H]5C[C@H](O)[C@H](O[C@H]6C[C@H](O)[C@H](O[C@H]7C[C@H](O)[C@H](O)[C@@H](C)O7)[C@@H](C)O6)[C@@H](C)O5)CC4)[H])(CC[C@]1(C)[C@H](CC2)C=8COC(=O)C8)[H])[H]

Sinónimos:

• (3beta,5beta)-3-{[2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1->4)-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1->4)-2,6-dideoxy-beta-D-ribo-hexopyranosyl]oxy}-14-hydroxycard-20(22)-enolide
• (3beta,5beta,8xi,9xi)-3-{[2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1->4)-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1->4)-2,6-dideoxy-beta-D-ribo-hexopyranosyl]oxy}-14-hydroxycard-20(22)-enolide
• (3β,5β)-3-[(O-2,6-Dideoxy-β-<span class="text-smallcaps">D</smallcap>-ribo-hexopyranosyl-(1→4)-O-2,6-dideoxy-β-<smallcap>D</smallcap>-ribo-hexopyranosyl-(1→4)-2,6-dideoxy-β-<smallcap>D</span>-ribo-hexopyranosyl)oxy]-14-hydroxycard-20(22)-enolide
• 3-{[2,6-Dideoxyhexopyranosyl-(1->4)-2,6-Dideoxyhexopyranosyl-(1->4)-2,6-Dideoxyhexopyranosyl]Oxy}-14-Hydroxycard-20(22)-Enolide
• Card-20(22)-enolide, 3-[(O-2,6-dideoxy-β-<span class="text-smallcaps">D</smallcap>-ribo-hexopyranosyl-(1→4)-O-2,6-dideoxy-β-<smallcap>D</smallcap>-ribo-hexopyranosyl-(1→4)-2,6-dideoxy-β-<smallcap>D</span>-ribo-hexopyranosyl)oxy]-14-hydroxy-, (3β,5β)-
• Card-20(22)-enolide, 3-[(O-2,6-dideoxy-β-D-ribo-hexopyranosyl-(1→4)-O-2,6-dideoxy-β-D-ribo-hexopyranosyl-(1→4)-2,6-dideoxy-β-D-ribo-hexopyranosyl)oxy]-14-hydroxy-, (3β,5β)-
• Cardidigin
• Cardigin
• Carditoxin
• Coramedan
• Cristapurat
• Crystalline digitalin
• Crystodigin
• Digicor
• Digilong
• Digimed
• Digimerck
• Digipural
• Digisidin
• Digitaline Nativelle
• Digitophyllin
• Digitoxigenin tridigitoxoside
• Digitoxina
• Digitoxine
• Digitoxoside
• Digitrin
• Ditaven
• Glucodigin
• Lanatoxin
• Myodigin
• Nsc 7529
• Purodigin
• Purpurid
• Tradigal
• Unidigin
• Digitoxin
• (3β,5β)-3-[(O-2,6-Dideoxy-β-D-ribo-hexopyranosyl-(1→4)-O-2,6-dideoxy-β-D-ribo-hexopyranosyl-(1→4)-2,6-dideoxy-β-D-ribo-hexopyranosyl)oxy]-14-hydroxycard-20(22)-enolide
• 4)-O-2,6-dideoxy-b-D-ribo-hexopyranosyl-(1&reg
• Digitoksin
• Acedoxin
• Card-20(22)-enolide, 3-[(O-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1.-&gt
• mono-digitoxid
• monodigitoxoside
• Card-20(22)-enolide,3-[(O-2,6-dideoxy-b-D-ribo-hexopyranosyl-(1&reg
• .4)-2,6-dideoxy-beta-D-ribo-hexopyranosyl)oxy]-14-hydroxy-, (3beta,5beta)-
• 4)-2,6-dideoxy-b-D-ribo-hexopyranosyl)oxy]-14-hydroxy-, (3b,5b)-
• digitoxigenin-tridigitoxosid
• Tri-digitoxoside
• digitalinecristallisee
• (3beta,5beta)-3-((O-2,6-Dideoxy-beta-D-ribo-hexopyranosyl-(1-4)-O-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1-4)-2,6-dideoxy-beta-D-ribo-hexopyranosyl)oxy)-14-hydroxy-card-20(22)-enolide
• DIGITALIN
• Purodigin, crystalline
• 4)-2,6-dideoxy-beta-D-ribo-hexopyranosyl)oxy]-14-hydroxy-, (3beta,5beta)-
• Card-20(22)-enolide, 3-[(O-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1--&gt
• digitoksim
• Digitoxin ,>=95%
• Digitaline cristallisee
• Digtoxoside
• hexopyranosyl-(1→4)-O-2,6-dideoxy-β-D-ribo-
• digitoxinum
• digitoxigenintridigitoxoside
• 6-dideoxy-beta-d-ribo-o-6-dideoxy-beta-d-ribo-hexopyranosyl-(1.fwdarw.4)-2
• Tardigal
• Digitoxin (8CI)
• hexopyranosyl-(1→4)-2,6-dideoxy-β-D-ribo-
• Card-20(22)-enolide, 3-[(O-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(14)-O-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(14)-2,6-dideoxy-beta-D-ribo-hexopyranosyl
• digitalin,crystalline
• Digitoxin,5β,20(22)-Cardenolide-3β,14-diol-3-(O-2,6-dideoxy-β-D-ribo-hexopyranosyl-[1→4]-O-2,6-dideoxy-β-D-ribo-hexopyranosyl-[1→4]-2,6-dideoxy-β-D-ribo-hexopyranosyl)oxy
• ta-d-ribo-hexopyranosyl-(1-4)-2,6-dideoxy-beta-d-ribo-hexopyranosyl)oxy)-14-hy
• Digitogenin
• Digitoxin solution
• mono-glycocard
• Cristodigin
• (3beta,5beta)-y)-14-hydroxy
• 4)-O-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1--&gt
• 5beta-Card-20(22)-enolide, 3beta,14-dihydroxy-, 3-(tris-(digitoxoside))
• (3beta,5beta)-3-((o-2,6-dideoxy-beta-d-ribohexopyranosyl-(1-4)-o-2,6-dideoxy-be
• 3-((2,6-Dideoxy-4-O-[2,6-dideoxy-4-O-(2,6-dideoxyhexopyranosyl)hexopyranosyl]hexopyranosyl)oxy)-14-hydroxycard-20(22)-enolide
• Card-20(22)-enolide, 3-(O-2,6-dideoxy-.beta.-D-ribo-hexopyranosyl-(1?4)-O-2,6-dideoxy-.beta.-D-ribo-hexopyranosyl-(1?4)-2,6-dideoxy-.beta.-D-ribo-hexopyranosyl)oxy-14-hydroxy-, (3.beta.,5.beta.)-
• carditalin
• digitalinenativelle
• hexopyranosyl)oxy]-14-hydroxy-, (3β,5β)-
• DIGITOXIN CRYSTALLINE
• Digitalinum verum
• 5β,20(22)-cardenolide-3β,14-diol-3-(o-2,6-dideoxy-β-d-ribo-hexopyranosyl-[1→4]-o-2,6-dideoxy-β-d-ribo-hexopyranosyl-[1→4]-2,6-dideoxy-β-d-ribo-hexopyranosyl)oxy
• Digitoxin,99%
• Digitoxoside (7CI)
• (3beta,5beta)-hexopyranosyl)oxy]-14-hydroxy
• Digitoxin (200 mg)
• Card-20(22)-enolide, 3-((O-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1-4)-O-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1-4)-2,6-dideoxy-beta-D-ribo-hexopyranosyl)oxy)-14-hydroxy-, (3beta,5beta)-
• .4)-O-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1.-&gt
• De-Tone
• (3,5)-3-[(O-2,6-Dideoxy--D-ribo-hexopyranosyl-(1-4)-O-2,6-dideoxy--D-ribo-hexopyranosyl-(1-4)-2,6-dideoxy--D-ribo-hexopyranosyl)oxyl]-14-hydroxycard-20(22)-enolide
• Natigal
• DIGITOXIN,USP
• asthenthilo
• 3-[(o-2,6-dideoxy-beta-d-ribo-hexopyranosyl-(1.fwdarw.4)-card-20(22)-enolid
• Card-20(22)-enolide, 3-[(O-2,6-dideoxy-β-D-ribo-
• DIGITOXIN(P)
• 20(22),5BETA-CARDENOLID-3BETA,14BETA-DIOL 3BETA-2,6-DIDEOXY-(4->O)-[2,6-DIDEOXY-4(4->O)-(2,6-DIDEOXY-BETA-D-RIBOHEXOPYRANOSYL)-BETA-D-RIBOHEXOPYRANOSID]
• 5BETA,20[22]-CARDENOLIDE-3BETA,14-DIOL-3[O-2,6-DIDEOXY-BETA-D-RIBO-HEXOPYRANOSYL-(1->4)-O-2,6-DIDEOXY-BETA-D-RIBO-HEXOPYRANOSYL-(1->4)-2,6-DIDEOXY-BETA-D-RIBO-HEXOPYRANOSYL]OXY
• (3b,5b)-3-[(O-2,6-Dideoxy-b-D-ribo-hexopyranosyl-(1-4)-O-2,6-dideoxy-b-D-ribo-hexopyranosyl-(1-4)-2,6-dideoxy-b-D-ribo-hexopyranosyl)oxyl]-14-hydroxycard-20(22)-enolide
• digitalinumverum

Digitoxin

CAS: 71-63-6

Digitoxin analytical standard provided with w/w absolute assay, to be used for quantitative titration.

Fórmula: C₄₁H₆₄O₁₃

Pureza: (HPLC) ≥98%

Cor e Forma: Powder

Peso molecular: 764.96

Ref: 11-0814S

Digitoxin

CAS: 71-63-6

Digitoxin

Fórmula: C₄₁H₆₄O₁₃

Pureza: 97.9%

Cor e Forma: Off-White

Peso molecular: 764.43469

Ref: 47-855

DIGITOXIN RS

CAS: 71-63-6

DIGITOXIN RS

Fórmula: C₄₁H₆₄O₁₃

Peso molecular: 764.9391

Ref: 41-ICRS0288

DIGITOXIN FOR LC ASSAY CRS

CAS: 71-63-6

DIGITOXIN FOR LC ASSAY CRS

Ref: 41-Y0002036

DIGITOXIN CRS

CAS: 71-63-6

DIGITOXIN CRS

Fórmula: C₄₁H₆₄O₁₃

Cor e Forma: Powder. White. Whitish.

Peso molecular: 764.9391

Ref: 41-D1800000

Digitoxin

CAS: 71-63-6

Other glycosides, natural or reproduced by synthesis, and their salts, ethers, esters and other derivatives

Fórmula: C₄₁H₆₄O₁₃

Cor e Forma: White Off-White Crystalline Powder

Peso molecular: 764.94 g/mol

Ref: 45-1199002

Digitoxin

CAS: 71-63-6

Digitoxin (Digitoxinum) is an effective Na+/K+-ATPase inhibitor (EC50 value: 0.78 μM).

Fórmula: C₄₁H₆₄O₁₃

Pureza: 98.23% - 98.54%

Cor e Forma: Very Small Elongated Rectangular Plates From Dilute Alcohol 1998)

Peso molecular: 764.94

Ref: TM-T0295

Digitoxin

CAS: 71-63-6

Fórmula: C₄₁H₆₄O₁₃

Peso molecular: 764.94

Ref: 7W-GC5627

Digitoxin (Digoxin EP Impurity A)

CAS: 71-63-6

Fórmula: C₄₁H₆₄O₁₃

Cor e Forma: White To Off-White Solid

Peso molecular: 764.95

Ref: 4Z-D-461

Digitoxin

Produto Controlado

CAS: 71-63-6

Fórmula: C₄₁H₆₄O₁₃

Cor e Forma: Neat

Peso molecular: 764.94

Ref: 04-C12633800

Digitoxin 100 µg/mL in Acetonitrile

CAS: 71-63-6

Fórmula: C₄₁H₆₄O₁₃

Cor e Forma: Single Solution

Peso molecular: 764.94

Ref: 04-A12633800AL-100

Digitoxin

CAS: 71-63-6

Fórmula: C₄₁H₆₄O₁₃

Pureza: >97.0%(HPLC)

Cor e Forma: White to Almost white powder to crystal

Peso molecular: 764.95

Ref: 3B-D0542

Digitoxin

CAS: 71-63-6

Fórmula: C₄₁H₆₄O₁₃

Pureza: 95%~99%

Peso molecular: 764.95

Ref: BP-BP0489

Digitoxin

CAS: 71-63-6

Digitalis glycoside

Fórmula: C₄₁H₆₄O₁₃

Pureza: ≥ 95.0 % (HPLC)

Cor e Forma: Powder

Peso molecular: 764.95

Ref: 5G-82516

Digitoxin-21,23,23-d3

Produto Controlado

CAS: 71-63-6

Applications Isotope labelled Digitoxin (D445950), is used as a cardiotonic.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Foerster, et al.: Arch. Int. Pharmacodyn. Ther., 159, 1 (1966), Jakovljevic, I.M., Anal. Profiles Drug Subs., 3, 149 (1974)

Fórmula: C₄₁H₆₁D₃O₁₃

Pureza: 90%

Cor e Forma: Neat

Peso molecular: 767.96

Ref: TR-D445952

Digitoxin

CAS: 71-63-6

Stability Hygroscopic
Applications Cardiotonic.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Foerster, et al.: Arch. Int. Pharmacodyn. Ther., 159, 1 (1966), Jakovljevic, I.M., Anal. Profiles Drug Subs., 3, 149 (1974)

Fórmula: C₄₁H₆₄O₁₃

Cor e Forma: White To Off-White

Peso molecular: 764.94

Ref: TR-D445950

Digitoxin

CAS: 71-63-6

Digitoxin is a cardiac glycoside, which is a type of compound extracted primarily from the leaves of the Digitalis purpurea plant, also known as the common foxglove. This natural source provides digitoxin with its potent pharmacological properties.

Fórmula: C₄₁H₆₄O₁₃

Pureza: Min. 95 Area-%

Cor e Forma: White Off-White Powder

Peso molecular: 764.96 g/mol

Ref: 3D-OD09336

Digoxin EP Impurity A

CAS: 71-63-6

Fórmula: C₄₁H₆₄O₁₃

Peso molecular: 765

Ref: ST-EA-CP-D1200001

DigitoXin, USP

CAS: 71-63-6

Fórmula: C₄₁H₆₄O₁₃

Pureza: 92%

Cor e Forma: Solid

Peso molecular: 764.9391

Ref: IN-DA003PIK