CAS 71142-71-7

H-D-Fenil-Pro-Arg-clorometilcetona

Descrição:

H-D-Fenil-Pro-Arg-clorometilcetona, também conhecido pelo seu número CAS 71142-71-7, é um derivado de peptídeo sintético que atua como um potente inibidor de certas enzimas proteolíticas, particularmente as serina proteases. Este composto apresenta um grupo funcional clorometilcetona, que é crucial para seu mecanismo de ação, permitindo-lhe formar ligações covalentes com o sítio ativo das enzimas-alvo, inibindo assim sua atividade. A presença dos aminoácidos fenilalanina (Phe), prolina (Pro) e arginina (Arg) em sua estrutura contribui para sua especificidade e afinidade de ligação. H-D-Fenil-Pro-Arg-clorometilcetona é frequentemente utilizado em pesquisas bioquímicas para estudar a cinética enzimática e a inibição de proteases, tornando-o valioso no desenvolvimento de medicamentos e aplicações terapêuticas. Sua estabilidade e reatividade são influenciadas pelo pH e pelas condições de temperatura circundantes, que são considerações importantes em montagens experimentais. Assim como muitos derivados de peptídeos, é essencial manusear este composto com cuidado, aderindo aos protocolos de segurança devido à sua potencial atividade biológica.

Fórmula: C₂₁H₃₁ClN₆O₃

InChI: InChI=1/C21H31ClN6O3/c22-13-18(29)16(8-4-10-26-21(24)25)27-19(30)17-9-5-11-28(17)20(31)15(23)12-14-6-2-1-3-7-14/h1-3,6-7,15-17H,4-5,8-13,23H2,(H,27,30)(H4,24,25,26)/t15-,16+,17+/m1/s1

Chave InChI: InChIKey=KWPACVJPAFGBEQ-IKGGRYGDSA-N

SMILES: C(N[C@@H](CCCNC(=N)N)C(CCl)=O)(=O)[C@H]1N(C([C@@H](CC2=CC=CC=C2)N)=O)CCC1

Sinónimos:

• 13: PN: WO03076461 PAGE: 51 claimed protein
• <span class="text-smallcaps">D</smallcap>-Phenylalanyl-<smallcap>L</smallcap>-prolyl-<smallcap>L</span>-arginyl chloromethyl ketone
• <span class="text-smallcaps">D</smallcap>-Phenylalanyl-N-[(1S)-4-[(aminoiminomethyl)amino]-1-(2-chloroacetyl)butyl]-<smallcap>L</span>-prolinamide
• <span class="text-smallcaps">D</span>-Phenylalanyl-prolyl-arginyl chloromethyl ketone
• <span class="text-smallcaps">L</smallcap>-Prolinamide, <smallcap>D</span>-phenylalanyl-N-[(1S)-4-[(aminoiminomethyl)amino]-1-(2-chloroacetyl)butyl]-
• <span class="text-smallcaps">L</smallcap>-Prolinamide, <smallcap>D</span>-phenylalanyl-N-[(1S)-4-[(aminoiminomethyl)amino]-1-(chloroacetyl)butyl]-
• <span class="text-smallcaps">L</smallcap>-Prolinamide, <smallcap>D</span>-phenylalanyl-N-[4-[(aminoiminomethyl)amino]-1-(chloroacetyl)butyl]-, (S)-
• D-Phe-pro-arg CH2Cl
• D-Phenylalanine-proline-arginine methyl chloride
• D-phenylalanyl-N-{(1S)-1-(chloroacetyl)-4-[(diaminomethylidene)amino]butyl}-L-prolinamide
• H-D-Phe-Pro-Arg-Chloromethylketone Trifluoroacetate Salt
• L-Prolinamide, D-phenylalanyl-N-(4-((aminoiminomethyl)amino)-1-(chloroacetyl)butyl)-, (S)-
• Pebac
• Phe-pro-arg-methyl chloride
• Phenylalanyl-prolyl-arginine methyl chloride
• Ppack
• L-Prolinamide, D-phenylalanyl-N-[(1S)-4-[(aminoiminomethyl)amino]-1-(2-chloroacetyl)butyl]-
• D-Phenylalanyl-L-prolyl-L-arginyl chloromethyl ketone
• D-Phenylalanyl-N-[(1S)-4-[(aminoiminomethyl)amino]-1-(2-chloroacetyl)butyl]-L-prolinamide
• L-Prolinamide, D-phenylalanyl-N-[(1S)-4-[(aminoiminomethyl)amino]-1-(chloroacetyl)butyl]-
• H-D-PHE-PRO-ARG-CHLOROMETHYLKETONE TRIFLUOROACETATE SALT USP/EP/BP
• H-D-Phe-Pro-Arg-CMK
• phenylalanyl-prolyl-argininemethylchloride
• D-Phe-Pro-Arg-CMK.TFA
• H-D-PHE-PRO-ARG-CMK TFA

H-D-Phe-Pro-Arg-chloromethylketone

CAS: 71142-71-7

PPACK, fPR-CMK, a highly effective irreversible inhibitor of thrombin and gingipain R.

Fórmula: C₂₁H₃₁ClN₆O₃

Pureza: 91.3%

Cor e Forma: Yellowish Powder

Peso molecular: 450.97

Ref: 01-4033019

D-Phenylalanyl-prolyl-arginyl chloromethyl ketone

CAS: 71142-71-7

D-Phenylalanyl-prolyl-arginyl chloromethyl ketone is a chemical compound that inhibits the proteolytic activity of serine proteases. It binds to the thrombin receptor on the surface of cells and prevents activation of fibrinogen by thrombin, which is an enzyme that promotes clotting. D-Phenylalanyl-prolyl-arginyl chloromethyl ketone also blocks platelet aggregation and has shown an ability to induce muscle cell proliferation. This drug has been used in pharmacological experiments as an inhibitor binding agent.

Fórmula: C₂₁H₃₁ClN₆O₃

Pureza: Min. 90 Area-%

Cor e Forma: Powder

Peso molecular: 450.96 g/mol

Ref: 3D-FP46717

PPACK

CAS: 71142-71-7

PPACK: synthetic peptide, irreversibly inhibits thrombin (Ki = 0.24 nM), prevents platelet activation.

Fórmula: C₂₁H₃₁ClN₆O₃

Pureza: 98%

Cor e Forma: Solid

Peso molecular: 450.96

Ref: TM-T20505