CAS 71610-00-9

Cefalomannina

Descrição:

Cefalomannina é um composto natural classificado como um tipo de alcaloide, especificamente derivado da espécie de planta *Cephalotaxus*, comumente conhecida como teixo de ameixa. Este composto é caracterizado por sua complexa estrutura molecular, que inclui múltiplos anéis e grupos funcionais que contribuem à sua atividade biológica. Cefalomannina exibe notáveis propriedades farmacológicas, incluindo potenciais efeitos anti-câncer e imunomoduladores, tornando-o de interesse na química medicinal e na pesquisa farmacêutica. Seu mecanismo de ação geralmente envolve interação com vias celulares, influenciando a proliferação celular e a apoptose. O composto é tipicamente estudado no contexto de suas aplicações terapêuticas, particularmente em oncologia. Além disso, Cefalomannina é solúvel em solventes orgânicos, o que é relevante para sua extração e formulação em várias aplicações. Assim como muitos produtos naturais, o estudo de Cefalomannina também inclui investigações sobre sua biossíntese e os papéis ecológicos que pode desempenhar dentro de sua espécie de planta nativa. No geral, Cefalomannina representa uma área significativa de interesse para pesquisadores que exploram compostos naturais com potenciais benefícios à saúde.

Fórmula: C₄₅H₅₃NO₁₄

InChI: InChI=1/C45H53NO14/c1-9-23(2)39(52)46-33(27-16-12-10-13-17-27)34(50)41(54)58-29-21-45(55)38(59-40(53)28-18-14-11-15-19-28)36-43(8,30(49)20-31-44(36,22-56-31)60-26(5)48)37(51)35(57-25(4)47)32(24(29)3)42(45,6)7/h9-19,29-31,33-36,38,49-50,55H,20-22H2,1-8H3,(H,46,52)/b23-9+/t29-,30-,31+,33-,34+,35+,36-,38-,43+,44-,45+/m0/s1

Chave InChI: InChIKey=DBXFAPJCZABTDR-WBYYIXQISA-N

SMILES: O(C(C)=O)[C@]12[C@]3([C@H](OC(=O)C4=CC=CC=C4)[C@@]5(O)C(C)(C)C([C@@H](OC(C)=O)C(=O)[C@]3(C)[C@@H](O)C[C@]1(OC2)[H])=C(C)[C@@H](OC([C@@H]([C@@H](NC(/C(=C/C)/C)=O)C6=CC=CC=C6)O)=O)C5)[H]

Sinónimos:

• (2alpha,3xi,5beta,7beta,10beta,13alpha)-4,10-bis(acetyloxy)-1,7-dihydroxy-13-{[(2R,3S)-2-hydroxy-3-{[(2E)-2-methylbut-2-enoyl]amino}-3-phenylpropanoyl]oxy}-9-oxo-5,20-epoxytax-11-en-2-yl benzoate
• (2alpha,5beta,7beta,10beta)-4,10-bis(acetyloxy)-1,7-dihydroxy-13-({(2R,3S)-2-hydroxy-3-[(2-methylbut-2-enoyl)amino]-3-phenylpropanoyl}oxy)-9-oxo-5,20-epoxytax-11-en-2-yl benzoate
• (2alpha,5beta,7beta,10beta,13alpha)-4,10-bis(acetyloxy)-1,7-dihydroxy-13-{[(2R,3S)-2-hydroxy-3-{[(2E)-2-methylbut-2-enoyl]amino}-3-phenylpropanoyl]oxy}-9-oxo-5,20-epoxytax-11-en-2-yl benzoate
• 7,11-Methano-1H-cyclodeca[3,4]benz[1,2-b]oxete, benzenepropanoic acid deriv.
• Benzenepropanoic acid, alpha-hydroxy-beta-(((2E)-2-methyl-1-oxo-2-butenyl)amino)-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca(3,4)benz(1,2-b)oxet-9-yl ester, (alphaR,betaS)-
• Benzenepropanoic acid, alpha-hydroxy-beta-((2-methyl-1-oxo-2-butenyl)amino)-, 6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca(3,4)benz(1,2-b)oxet-9-yl ester, (2aR-(2aalpha,4beta,4abeta,6beta,9alpha(aR*,betaS*),11alpha,12alpha,12aalpha,12balpha))-
• Benzenepropanoic acid, α-hydroxy-β-[(2-methyl-1-oxo-2-butenyl)amino]-, 6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, [2aR-[2aα,4β,4aβ,6β,9α[αR*,βS*(E)],11α,12α,12aα,12bα]]-
• Benzenepropanoic acid, α-hydroxy-β-[[(2E)-2-methyl-1-oxo-2-buten-1-yl]amino]-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, (αR,βS)-
• Benzenepropanoic acid, α-hydroxy-β-[[(2E)-2-methyl-1-oxo-2-butenyl]amino]-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, (αR,βS)-
• Nsc 318735
• Taxol B
• Cephalomannine
• Cephalomannine, 98%, from Taxus chinensis (Pilg.) Rehder
• CEPHALOMANNINE (TAXOL B)
• 12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetraMethyl-5-oxo-7,11-Methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl Ester
• Benzenepropanoic acid, α-hydroxy-β-[[(2E)-2-methyl-1-oxo-2-buten-1-yl]amino]-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, ...
• Paclitaxel Impurity 2（Paclitaxel EP Impurity B）
• CEPHALOMANNINE(P)
• CEPHALOMANNINE:BENZENEPROPANOICACID, -HYDROXY--[(2-METHYL-1-OXO-2-BUTENYL)AMINO]-,6,12B-BIS(ACETYLOXY)-12-(BENZOYLOXY)-2A,3,4,4A,5,6,9,10,11,12,12A,12B-DODECAHYDRO-4,11-DIHYDROXY-4A,8,13,13-TETRAMETHYL-5-OXO-7,11-METHANO-1H-CYCLODECA[3,4]BENZ[1,2-B]OX...
• Paclitaxel Related CoMpound A
• CephaloMannine, froM Taxus chinensis
• Paclitaxel EP Impurity B
• BENZENEPROPANOIC ACID, ALPHA-HYDROXY-BETA-[(2-METHYL-1-OXO-2-BUTENYL)AMINO]-,6,12B-BIS(ACETYLOXY)-12-(BENZOYLOXY)-2A,3,4,4A,5,6,9,10,11,12,12A,12B-DODECAHYDRO-4,11-DIHYDROXY-4A,8,13,13-TETRAMETHYL-5-OXO-7,11-METHANO-1H-CYCLODECA[3,4]BENZ[1,2-B]OXET-9-YL ESTER,[2AR-[2A,4,4A,6,9[R*,S*(E)],11,12,12A,12B]]-
• BENZENEPROPANOICACID,ALPHA-HYDROXY-BETA-[(2-METHYL-1-OXO-2-BUTENYL)AMINO]-,6,12B-BIS(ACETYLOXY)-12-(BENZOYLOXY)-2A,3,4,4A,5,6,9,10,11,12,12A,12B-DODECAHYDRO-4,11-DIHYDROXY-4A,8,13,13-TETRAMETHYL-5-OXO-7,11-METHANO-1H-CYCLODECA[3,4]BENZ[1,2-
• Cephalomannine, >99%
• paclitaxel iMpurity I
• Paclitaxel Impurity Ⅰ:Cephalomannine
• N-Debenzoyl-N-tigloylpaclitaxel
• N-debenzoyl-N-tigloylpaclitaxel (cephalomannine)
• Paclitaxel Related Compound A (Cephalomannine)
• 3′-N-(trans-2-methyl-2-butenoyl)-3′-N-debenzoylpaclitaxel
• N-Debenzoyl-N-tigloylpaclitaxel (Ce
• CEPHALOMANNINE:BENZENEPROPANOICACID, -HYDROXY--[(2-METHYL-1-OXO-2-BUTENYL)AMINO]-,6,12B-BIS(ACETYLOXY)-12-(BENZOYLOXY)-2A,3,4,4A,5,6,9,10,11,12,12A,12B-DODECAHYDRO-4,11-DIHYDROXY-4A,8,13,13-TETRAMETHYL-5-OXO-7,11-METHANO-1H-CYCLODECA[3,4]BENZ[1
• Cephalomannine 71610-00-9
• -[(2-methyl-1-oxo-2-butenyl)amino]-,6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-ylester,[2aR-[2aα,4β,4aβ,6β,9α[αR*,βS*(E)],11α,12α,12aα,12bα]]-
• Benzenepropanoicacid, α-hydroxy-β
• Cephalomannine USP/EP/BP
• Paclitaxel Related Compound A (20 mg) (Ce-phalomannine)

Paclitaxel Related Compound A (Cephalomannine)

CAS: 71610-00-9

Aromatic heterocyclic compounds with oxygen hetero-atom(s) only, nesoi

Fórmula: C₄₅H₅₃NO₁₄

Cor e Forma: White Off-White Powder

Peso molecular: 831.34661

Ref: 45-1491343

Cephalomannine

CAS: 71610-00-9

Fórmula: C₄₅H₅₃NO₁₄

Peso molecular: 831.90

Ref: 7W-GA4112

Cephalomannine (Paclitaxel USP Related Compound A)

CAS: 71610-00-9

Fórmula: C₄₅H₅₃NO₁₄

Cor e Forma: White To Off-White Solid

Peso molecular: 831.91

Ref: 4Z-C-11901

Cephalomannine

CAS: 71610-00-9

Cephalomannine

Pureza: ≥98%

Peso molecular: 831.9g/mol

Ref: 54-BUP00025

N-Debenzoyl-N-tigloylpaclitaxel (Cephalomannine)

CAS: 71610-00-9

Cor e Forma: Neat

Ref: 86-MM1489.02

Cephalomannine

CAS: 71610-00-9

Fórmula: C₄₅H₅₃NO₁₄

Pureza: 95%~99%

Peso molecular: 831.912

Ref: BP-BP0332

Cephalomannine

CAS: 71610-00-9

Cephalomannine (Baccatin III) is a taxol derivative obtained from Taxus yunnanensis with antitumor activity.

Fórmula: C₄₅H₅₃NO₁₄

Pureza: 98.77% - 99.75%

Cor e Forma: Solid

Peso molecular: 831.9

Ref: TM-T2217

Paclitaxel EP Impurity B

CAS: 71610-00-9

Fórmula: C₄₅H₅₃NO₁₄

Peso molecular: 831.90

Ref: ST-EA-CP-P36145

Cephalomannine

Produto Controlado

CAS: 71610-00-9

Fórmula: C₄₅H₅₃NO₁₄

Cor e Forma: White

Peso molecular: 831.90

Ref: TR-C258500

Cephalomannine

CAS: 71610-00-9

Pureza: 98%

Peso molecular: 831.912

Ref: 10-F987648

Cephalomannine

CAS: 71610-00-9

Cephalomannine is a diterpenoid alkaloid product, which is derived from the needles of the Taxus species, commonly known as yew trees. It is structurally similar to paclitaxel (Taxol), a well-known chemotherapeutic agent. The mode of action of cephalomannine involves binding to the β-subunit of tubulin, thereby promoting the polymerization of tubulin into stable microtubules while simultaneously inhibiting their depolymerization. This stabilization of the microtubule network disrupts the normal process of cell division, effectively arresting cell mitosis, which leads to cell death.

Fórmula: C₄₅H₅₃NO₁₄

Pureza: Min. 95%

Peso molecular: 831.9 g/mol

Ref: 3D-FC19896

Cephalomannine

CAS: 71610-00-9

Fórmula: C₄₅H₅₃NO₁₄

Peso molecular: 831.91

Ref: ST-EA-CP-C548004

Benzenepropanoic acid, α-hydroxy-β-[[(2E)-2-methyl-1-oxo-2-buten-1-yl]amino]-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, (αR,βS)-

CAS: 71610-00-9

Fórmula: C₃₇H₄₃NO₁₀

Cor e Forma: Solid

Peso molecular: 661.7380

Ref: IN-DA0038H4