CAS 71989-18-9

N-(9-Fluorenilmetoxicarbonil)-L-ácido glutâmico γ-terc-butil éster

Descrição:

N-(9-Fluorenilmetoxicarbonil)-L-ácido glutâmico γ-terc-butil éster, comumente referido como Fmoc-L-Glu(γ-tBu)-OH, é uma forma protegida do aminoácido L-ácido glutâmico. Este composto é caracterizado pela presença de um grupo 9-fluorenilmetoxicarbonila (Fmoc), que serve como um grupo protetor para a funcionalidade amino, permitindo reações seletivas durante a síntese de peptídeos. O grupo éster γ-tert-butilo fornece proteção adicional para a parte ácida carboxílica, aumentando a estabilidade e solubilidade do composto em solventes orgânicos. Fmoc-L-Glu(γ-tBu)-OH é tipicamente utilizado na síntese de peptídeos em fase sólida, onde facilita a montagem passo a passo de peptídeos enquanto previne reações secundárias indesejadas. O composto é geralmente estável sob condições laboratoriais padrão, mas pode exigir condições específicas para desproteção. Sua estrutura contribui para sua utilidade em bioquímica e química medicinal, particularmente na síntese de peptídeos com propriedades funcionais específicas.

Fórmula: C₂₄H₂₇NO₆

InChI: InChI=1S/C24H27NO6/c1-24(2,3)31-21(26)13-12-20(22(27)28)25-23(29)30-14-19-17-10-6-4-8-15(17)16-9-5-7-11-18(16)19/h4-11,19-20H,12-14H2,1-3H3,(H,25,29)(H,27,28)/t20-/m0/s1

Chave InChI: InChIKey=OTKXCALUHMPIGM-FQEVSTJZSA-N

SMILES: C(OC(N[C@@H](CCC(OC(C)(C)C)=O)C(O)=O)=O)C1C=2C(C=3C1=CC=CC3)=CC=CC2

Sinónimos:

• (2S)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-5-[(2-methylpropan-2-yl)oxy]-5-oxopentanoic acid
• (2S)-5-(tert-Butoxy)-2-([[(9H-fluoren-9-yl)methoxy]carbonyl]amino)-5-oxopentanoic acid
• (2S)-5-tert-Butoxy-2-(9H-fluoren-9-ylmethoxycarbonylamino)-5-oxo-pentanoic acid
• (2S)-5-tert-butoxy-2-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}-5-oxopentanoic acid (non-preferred name)
• (4S)-5-tert-butoxy-4-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}-5-oxopentanoic acid (non-preferred name)
• 5-tert-butoxy-4-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}-5-oxopentanoic acid (non-preferred name)
• <span class="text-smallcaps">L</span>-Glutamic acid, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-, 5-(1,1-dimethylethyl) ester
• FMOC-Glu(OtBu)-OH
• Fmoc-L-glutamic acid 5-tert-butyl ester
• N-(9-Fluorenylmethoxycarbonyl)-<span class="text-smallcaps">L</span>-glutamic acid γ-tert-butyl ester
• N-(9-Fluorenylmethoxycarbonyl)glutamic acid γ-tert-butyl ester
• N-(9-Fluorenylmethoxycarbonyl)-L-glutamic acid γ-tert-butyl ester
• L-Glutamic acid, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-, 5-(1,1-dimethylethyl) ester

5-tert-Butyl N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-glutamate

CAS: 71989-18-9

Fórmula: C₂₄H₂₇NO₆

Pureza: >98.0%(T)(HPLC)

Cor e Forma: White to Almost white powder to crystal

Peso molecular: 425.48

Ref: 3B-B3167

N-Fmoc-L-glutamic acid 5-tert-butyl ester, 98%

CAS: 71989-18-9

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Sci

Fórmula: C₂₄H₂₇NO₆

Pureza: 98%

Peso molecular: 425.48

Ref: 02-H59169

Fmoc-Glu(OtBu)-OH

CAS: 71989-18-9

Fórmula: C₂₄H₂₇NO₆

Pureza: 98%

Cor e Forma: Solid

Peso molecular: 425.4743

Ref: IN-DA0038GY

Fmoc-L-glutamic acid 5-tert-butyl ester

CAS: 71989-18-9

Fmoc-L-glutamic acid 5-tert-butyl ester

Pureza: ≥98%

Peso molecular: 425.47g/mol

Ref: 54-BUP19524

Fmoc-Glu(OtBu)-OH

CAS: 71989-18-9

Fórmula: C₂₄H₂₇NO₆

Pureza: ≥ 99.0%

Cor e Forma: White powder

Peso molecular: 425.48

Ref: 7W-GM7333

Fmoc-Glu(OtBu)-OH

CAS: 71989-18-9

M03409 - Fmoc-Glu(OtBu)-OH

Fórmula: C₂₄H₂₇NO₆

Pureza: 99%

Cor e Forma: Powder or Crystalline Powder or Solid

Peso molecular: 425.481

Ref: 10-M03409

Fmoc-L-glutamic acid 5-tert-butyl ester

CAS: 71989-18-9

Fmoc-L-glutamic acid 5-tert-butyl ester (Fmoc-Glu(OtBu)-OH) is a glutamic acid derivative.

Fórmula: C₂₄H₂₇NO₆

Pureza: 99.68%

Cor e Forma: Solid

Peso molecular: 425.47

Ref: TM-T64329

Fmoc-Glu(OtBu)-OH

CAS: 71989-18-9

Fmoc-Glu(OtBu)-OH

Fórmula: C₂₄H₂₇NO₆

Pureza: 98%

Cor e Forma: white powder

Peso molecular: 425.47g/mol

Ref: 54-OR911397

FMOC-L-Glutamic Acid 5-Tert-Butyl Ester (FMOC-Glu(OtBu)-OH) extrapure, 99%

CAS: 71989-18-9

Fórmula: C₂₄H₂₇NO₆

Pureza: min. 99%

Cor e Forma: White to off-white, Crystalline powder

Peso molecular: 425.47

Ref: SR-90673

Fmoc-Glu(OtBu)-OH

CAS: 71989-18-9

Fórmula: C₂₄H₂₇NO₆

Peso molecular: 425.5

Ref: ST-EA-CP-L28030

Fmoc-Glu(OtBu)-OH

CAS: 71989-18-9

Fmoc-Glu(OtBu)-OH is an amino acid that is used in the synthesis of peptides and proteins. It is a hydrophilic, non-polar amino acid with a hydroxyl group at its carboxy terminus. This substance has been shown to inhibit the growth of cancer cells in vitro and has been used for the development of monoclonal antibodies. Fmoc-Glu(OtBu)-OH has also been shown to have pharmacokinetic properties that are different from other amino acids such as L-lysine, which may be due to its hydrophilic interactions with plasma proteins. This compound is also toxic, as shown by studies on rats where it was found to cause liver damage at high doses. Fmoc-Glu(OtBu)-OH binds to receptors on cells known as polysialic acid receptors, which are involved in cell adhesion and migration. Fmoc-Glu

Fórmula: C₂₄H₂₇NO₆

Pureza: Min. 98 Area-%

Cor e Forma: Powder

Peso molecular: 425.47 g/mol

Ref: 3D-FF28968