CAS 72063-39-9

Espinosina

Descrição:

Espinosina, com o número CAS 72063-39-9, é um composto natural derivado principalmente da espécie vegetal *Ziziphus jujuba*, comumente conhecida como jujuba. Pertence à classe dos flavonoides e é reconhecido por suas potenciais propriedades farmacológicas. Espinosina é caracterizado por sua estrutura química única, que inclui uma espinha dorsal de flavona, contribuindo para sua bioatividade. Este composto despertou interesse no campo da medicina herbal devido aos seus efeitos ansiolíticos, sedativos e neuroprotetores relatados. Além disso, Espinosina exibe propriedades antioxidantes, que podem ajudar a mitigar o estresse oxidativo em sistemas biológicos. Seu perfil de solubilidade sugere que é mais solúvel em solventes orgânicos do que em água, o que pode influenciar sua biodisponibilidade e aplicações terapêuticas. A pesquisa sobre Espinosina continua a explorar seus mecanismos de ação e benefícios potenciais no tratamento de várias condições de saúde, particularmente aquelas relacionadas à ansiedade e distúrbios do sono. No geral, Espinosina representa uma área significativa de interesse na química de produtos naturais e farmacologia.

Fórmula: C₂₈H₃₂O₁₅

InChI: InChI=1S/C28H32O15/c1-39-14-7-15-18(12(32)6-13(40-15)10-2-4-11(31)5-3-10)22(35)19(14)26-27(24(37)21(34)16(8-29)41-26)43-28-25(38)23(36)20(33)17(9-30)42-28/h2-7,16-17,20-21,23-31,33-38H,8-9H2,1H3/t16-,17-,20-,21-,23+,24+,25-,26+,27-,28+/m1/s1

Chave InChI: InChIKey=VGGSULWDCMWZPO-ODEMIOGVSA-N

SMILES: O(C)C1=C(C(O)=C2C(=C1)OC(=CC2=O)C3=CC=C(O)C=C3)[C@H]4[C@H](O[C@@H]5O[C@H](CO)[C@@H](O)[C@H](O)[C@H]5O)[C@@H](O)[C@H](O)[C@@H](CO)O4

Sinónimos:

• (1S)-1,5-Anhydro-2-O-beta-D-glucopyranosyl-1-[5-hydroxy-2-(4-hydroxyphenyl)-7-methoxy-4-oxo-4H-chromen-6-yl]-D-glucitol
• 4H-1-Benzopyran-4-one, 6-(2-O-beta-D-glucopyranosyl-beta-D-glucopyranosyl)-5-hydroxy-2-(4-hydroxyphenyl)-7-methoxy-
• 4H-1-Benzopyran-4-one, 6-(2-O-β-<span class="text-smallcaps">D</smallcap>-glucopyranosyl-β-<smallcap>D</span>-glucopyranosyl)-5-hydroxy-2-(4-hydroxyphenyl)-7-methoxy-
• 6-(2-O-beta-D-Glucopyranosyl-beta-D-glucopyranosyl)-5-hydroxy-2-(4-hydroxyphenyl)-7-methoxy-4H-1-benzopyran-4-one
• 6-(2-O-β-<span class="text-smallcaps">D</smallcap>-Glucopyranosyl-β-<smallcap>D</span>-glucopyranosyl)-5-hydroxy-2-(4-hydroxyphenyl)-7-methoxy-4H-1-benzopyran-4-one
• D-glucitol, 1,5-anhydro-2-O-beta-D-glucopyranosyl-1-C-[5-hydroxy-2-(4-hydroxyphenyl)-7-methoxy-4-oxo-4H-1-benzopyran-6-yl]-, (1S)-
• Flavoayamenin
• Spinosin
• Swertisin 2′′-O-glucoside
• 6-(2-O-β-D-Glucopyranosyl-β-D-glucopyranosyl)-5-hydroxy-2-(4-hydroxyphenyl)-7-methoxy-4H-1-benzopyran-4-one
• 4H-1-Benzopyran-4-one, 6-(2-O-β-D-glucopyranosyl-β-D-glucopyranosyl)-5-hydroxy-2-(4-hydroxyphenyl)-7-methoxy-

Spinosin

CAS: 72063-39-9

Other glycosides, natural or reproduced by synthesis, and their salts, ethers, esters and other derivatives

Fórmula: C₂₈H₃₂O₁₅

Cor e Forma: Yellow Powder

Peso molecular: 608.17412

Ref: 45-1618717

Spinosin

CAS: 72063-39-9

Fórmula: C₂₈H₃₂O₁₅

Pureza: 95%

Cor e Forma: Solid

Peso molecular: 608.5447

Ref: IN-DA00FBG1

Spinosin

CAS: 72063-39-9

Spinosin

Pureza: ≥98%

Peso molecular: 608.54g/mol

Ref: 54-BUP00112

Spinosin

CAS: 72063-39-9

Spinosin

Pureza: 95%

Peso molecular: 608.54g/mol

Ref: 54-OR1024110

Spinosin

CAS: 72063-39-9

Fórmula: C₂₈H₃₂O₁₅

Peso molecular: 608.55

Ref: 7W-GY0454

Spinosin

CAS: 72063-39-9

Spinosin has neuroprotective, anxiolytic-like and anti-inflammatory effects, it ameliorated memory impairment induced through AβO, the serotonergic neurotransmitter system, it also potentiated pentobarbital-induced sleep via the serotonergic system.

Fórmula: C₂₈H₃₂O₁₅

Pureza: 95%~99%

Peso molecular: 608.549

Ref: BP-BP1336

Spinosin

CAS: 72063-39-9

Fórmula: C₂₈H₃₂O₁₅

Pureza: >95.0%(HPLC)

Cor e Forma: White to Light yellow powder to crystal

Peso molecular: 608.55

Ref: 3B-P2887

Spinosin

CAS: 72063-39-9

1.

Fórmula: C₂₈H₃₂O₁₅

Pureza: 98.16% - 99.75%

Cor e Forma: Solid

Peso molecular: 608.54

Ref: TM-T6S2227

Spinosin

CAS: 72063-39-9

Natural glycoside

Fórmula: C₂₈H₃₂O₁₅

Pureza: ≥ 90.0 % (HPLC)

Cor e Forma: Powder

Peso molecular: 608.55

Ref: 5G-83284

Spinosin

Produto Controlado

CAS: 72063-39-9

Applications Spinosin is a C-glycoside flavonoid extracted from Zizhiphi Spinozae, improved pentobarbital-induced sleep.
References Wang, Li. et al.: Pharm. Biochem. Behav., 90, 399 (2008);

Fórmula: C₂₈H₃₂O₁₅

Cor e Forma: Neat

Peso molecular: 608.54

Ref: TR-S681950

Spinosin

CAS: 72063-39-9

Spinosin is a natural product that belongs to the group of pyrrolizidine alkaloids. It has been shown to have physiological function as it can inhibit the 5-HT1A receptor and thereby regulate neurotransmitter release. Spinosin also has anti-inflammatory effects and can be used in the treatment of skin disorders, such as psoriasis. In vitro studies have shown that spinosin is a substrate for P-gp and interacts with other drugs by inhibiting their absorption in the gut and liver. Spinosin has been found to bind to monoclonal antibodies, which may be due to its structural similarity to chinese herb, a known antigenic protein. This leads to increased uptake of spinosin into cells and thus makes it an analytical method for measuring spinosin in biological samples. Spinosin activates p38mapk which then causes the phosphorylation of ERK1/2, leading to receptor binding and activation of downstream signaling pathways.

Fórmula: C₂₈H₃₂O₁₅

Pureza: Min. 95%

Cor e Forma: Powder

Peso molecular: 608.54 g/mol

Ref: 3D-FS65586