CAS 73032-94-7

somatostatina 28

Descrição:

somatostatina 28 é um hormônio peptídico que desempenha um papel crucial na regulação de vários processos fisiológicos, incluindo a inibição da liberação do hormônio do crescimento e a modulação da secreção de insulina e glucagon. É um membro da família da somatostatina, que consiste em várias isoformas, sendo somatostatina 28 uma das formas mais longas, derivada do precursor preprosomatostatina. Este peptídeo é composto por 28 aminoácidos e exibe uma estrutura cíclica que contribui para sua estabilidade e atividade biológica. somatostatina 28 é produzido principalmente no hipotálamo e no trato gastrointestinal, onde atua em receptores específicos para exercer seus efeitos. Suas funções se estendem ao sistema nervoso central, onde influencia a neurotransmissão e a sinalização neuroendócrina. O número CAS 73032-94-7 identifica exclusivamente este composto em bancos de dados químicos, facilitando a pesquisa e aplicação em farmacologia e bioquímica. No geral, somatostatina 28 é significativo tanto em ambientes clínicos quanto de pesquisa, particularmente na compreensão da regulação hormonal e das potenciais aplicações terapêuticas em distúrbios endócrinos.

Fórmula: C₁₃₇H₂₀₇N₄₁O₃₉S₃

InChI: InChI=1/C137H207N41O39S3/c1-69(154-113(194)82(37-19-22-47-138)159-115(196)85(40-25-50-149-136(145)146)160-118(199)87(44-45-106(188)189)163-116(197)86(41-26-51-150-137(147)148)164-130(211)101-43-27-52-177(101)133(214)72(4)156-114(195)88(46-54-218-7)158-110(191)71(3)155-129(210)100-42-28-53-178(100)134(215)95(61-104(144)186)171-126(207)96(65-180)172-124(205)93(59-102(142)184)165-111(192)70(2)153-112(193)80(141)64-179)109(190)152-63-105(187)157-98-67-219-220-68-99(135(216)217)174-127(208)97(66-181)173-132(213)108(74(6)183)176-125(206)91(57-77-33-15-10-16-34-77)170-131(212)107(73(5)182)175-119(200)84(39-21-24-49-140)161-122(203)92(58-78-62-151-81-36-18-17-35-79(78)81)168-121(202)90(56-76-31-13-9-14-32-76)166-120(201)89(55-75-29-11-8-12-30-75)167-123(204)94(60-103(143)185)169-117(198)83(162-128(98)209)38-20-23-48-139/h8-18,29-36,62,69-74,80,82-101,107-108,151,179-183H,19-28,37-61,63-68,138-141H2,1-7H3,(H2,142,184)(H2,143,185)(H2,144,186)(H,152,190)(H,153,193)(H,154,194)(H,155,210)(H,156,195)(H,157,187)(H,158,191)(H,159,196)(H,160,199)(H,161,203)(H,162,209)(H,163,197)(H,164,211)(H,165,192)(H,166,201)(H,167,204)(H,168,202)(H,169,198)(H,170,212)(H,171,207)(H,172,205)(H,173,213)(H,174,208)(H,175,200)(H,176,206)(H,188,189)(H,216,217)(H4,145,146,149)(H4,147,148,150)

SMILES: CC(C(=NCC(=NC1CSSCC(C(=O)O)N=C(C(CO)N=C(C(C(C)O)N=C(C(Cc2ccccc2)N=C(C(C(C)O)N=C(C(CCCCN)N=C(C(Cc2c[nH]c3ccccc23)N=C(C(Cc2ccccc2)N=C(C(Cc2ccccc2)N=C(C(CC(=N)O)N=C(C(CCCCN)N=C1O)O)O)O)O)O)O)O)O)O)O)O)O)N=C(C(CCCCN)N=C(C(CCCNC(=N)N)N=C(C(CCC(=O)O)N=C(C(CCCNC(=N)N)N=C(C1CCCN1C(=O)C(C)N=C(C(CCSC)N=C(C(C)N=C(C1CCCN1C(=O)C(CC(=N)O)N=C(C(CO)N=C(C(CC(=N)O)N=C(C(C)N=C(C(CO)N)O)O)O)O)O)O)O)O)O)O)O)O

Sinónimos:

• H-Ser-Ala-Asn-Ser-Asn-Pro-Ala-Met-Ala-Pro-Arg-Glu-Arg-Lys-Ala-Gly-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys-OH (Disulfide bond)
• Somatostatin 28, Cyclic

Somatostatin-28

CAS: 73032-94-7

The octacosapeptide somatostatin-28 arises from the posttranslational cleavage of prosomatostatin, which in turn is derived from a larger precursor, preprosomatostatin. S-28 was first isolated from porcine duodenum. In guinea-pig pancreatic acini, S-28, unlike S-14, increased amylase secretion, cellular cyclic GMP, and Ca²⁺ outfluxes.

Fórmula: C₁₃₇H₂₀₇N₄₁O₃₉S₃

Pureza: > 95%

Cor e Forma: Whitish Powder

Peso molecular: 3148.6

Ref: 01-4031270

Somatostatin-28

CAS: 73032-94-7

Somatostatin-28 H-Ser-Ala-Asn-Ser-Asn-Pro-Ala-Met-Ala-Pro-Arg-Glu-Arg-Lys-Ala-Gly (Disulfide bond) is a peptide hormone that is produced in the body by different tissues, including the pancreas. Somatostatin inhibits the release of various hormones, including growth hormone and insulin. It also has been shown to inhibit cell proliferation, tumor growth and angiogenesis in vitro. Somatostatin is used to diagnose diseases such as acute pancreatitis, chronic pancreatitis and prostate cancer. The somatostatin analog octreotide has been shown to reduce symptoms of diarrhea in patients with AIDS.

Fórmula: C₁₃₇H₂₀₇N₄₁O₃₉S₃

Pureza: Min. 95%

Peso molecular: 3,148.56 g/mol

Ref: 3D-FS109420

Somatostatin-28

CAS: 73032-94-7

Somatostatin-28 is the 28 amino acid isoform of somatostatin and has similar activity to the 14 amino acid isoform. While the 14 amino acid form mainly acts in the brain, somatostatin-28 mainly operates in the gastrointestinal tract. Somatostatin is a peptide hormone that is widely expressed throughout the body for example in the gastrointestinal (GI) tract, hypothalamus, pancreas and the central nervous system. It has been found to inhibit pituitary growth hormone release as well as endocrine, pancreatic and GI secretions. In the central nervous system somatostatin plays a role in neurotransmission modification and it has also demonstrated to be effective against a number of cancers such as squamous carcinoma.

Fórmula: C₁₃₇H₂₀₇N₄₁O₃₉S₃

Pureza: Min. 95%

Peso molecular: 3,148.62 g/mol

Ref: 3D-PSI-3747-PI

Somatostatin 28

CAS: 73032-94-7

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Fórmula: C₁₃₇H₂₀₇N₄₁O₃₉S₃

Cor e Forma: White to off-white, Powder

Peso molecular: 3148.58

Ref: 02-J66274