CAS 73232-52-7

Brometo de metilnaltrexona

Descrição:

Brometo de metilnaltrexona é um derivado de amônio quaternário da naltrexona, utilizado principalmente como medicamento para tratar a constipação induzida por opioides, particularmente em pacientes com doenças avançadas. Funciona como um antagonista do receptor mu-opioide de ação periférica, o que significa que bloqueia os efeitos dos opioides no trato gastrointestinal sem afetar o alívio da dor no sistema nervoso central. Essa ação seletiva ajuda a aliviar a constipação sem reverter a analgesia. Brometo de metilnaltrexona é tipicamente administrado por injeção subcutânea e tem um início de ação rápido. Sua estrutura química inclui um grupo metila ligado ao átomo de nitrogênio da espinha dorsal da naltrexona, o que melhora sua solubilidade e propriedades farmacocinéticas. A substância é geralmente bem tolerada, com efeitos colaterais comuns que incluem dor abdominal, diarreia e náusea. Devido ao seu mecanismo de ação específico, é particularmente benéfica para pacientes que estão em terapia crônica com opioides e experimentam constipação como efeito colateral. Brometo de metilnaltrexona é classificado como um medicamento sob prescrição e deve ser usado sob supervisão médica.

Fórmula: C₂₁H₂₆NO₄·Br

InChI: InChI=1S/C21H25NO4.BrH/c1-22(11-12-2-3-12)9-8-20-17-13-4-5-14(23)18(17)26-19(20)15(24)6-7-21(20,25)16(22)10-13;/h4-5,12,16,19,25H,2-3,6-11H2,1H3;1H/t16-,19+,20+,21-,22?;/m1./s1

Chave InChI: InChIKey=IFGIYSGOEZJNBE-KNLJMPJLSA-N

SMILES: O[C@]12[C@@]34C=5C(O[C@]3(C(=O)CC1)[H])=C(O)C=CC5C[C@]2([N+](CC6CC6)(C)CC4)[H].[Br-]

Sinónimos:

• (17RS)-17-(Cyclopropylmethyl)-4,5-alpha-epoxy-3,14-dihydroxy-17-methyl-6- oxomorphinanium bromide
• (5Alpha)-17-(Cyclopropylmethyl)-3,14-Dihydroxy-17-Methyl-4,5-Epoxymorphinan-17-Ium-6-One Bromide
• Methylnaltrexone bromide [USAN]
• Moa-728
• Morphinanium, 17-(cyclopropylmethyl)-4,5-epoxy-3,14-dihydroxy-17-methyl-6-oxo-, bromide (1:1), (5α)-
• Morphinanium, 17-(cyclopropylmethyl)-4,5-epoxy-3,14-dihydroxy-17-methyl-6-oxo-, bromide, (5alpha)-
• Mrz 2663
• Mrz 2663Br
• N-Cyclopropylmethyl-noroxymorphone methobromide
• N-Methylnaltrexone bromide
• Naltrexone methobromide
• Naltrexone methyl bromide
• Relistor
• Unii-Rfo6Il3D3M

Methylnaltrexone Bromide

CAS: 73232-52-7

Alkaloids of opium and their derivatives, salts thereof, not elsewhere specified or included

Fórmula: C₂₁H₂₆BrNO₄

Cor e Forma: White Off-White Powder

Peso molecular: 435.10452

Ref: 45-1430735

Methylnaltrexone bromide

CAS: 73232-52-7

Methylnaltrexone bromide

Pureza: ≥98%

Peso molecular: 436.35g/mol

Ref: 54-BUP05752

Methyl Naltrexone-d3 Bromide (Mixture of Diastereomers)

CAS: 73232-52-7

Fórmula: C₂₁H₂₃D₃NO₄·Br

Peso molecular: 359.46 79.90

Ref: 4Z-N-0135

Methylnaltrexone Bromide

CAS: 73232-52-7

Fórmula: C₂₁H₂₆NO₄·Br

Peso molecular: 356.44 79.90

Ref: 4Z-N-0140

Methylnaltrexone bromide

CAS: 73232-52-7

Methylnaltrexone bromide (MOA-728) is one of the newer agents of peripherally-acting μ-opioid antagonists, acts to reverse the side effects of opioid drugs.

Fórmula: C₂₁H₂₆BrNO₄

Pureza: 99.02%

Cor e Forma: Solid

Peso molecular: 436.35

Ref: TM-T21422

N-Methyl Naltrexone-d3 Bromide

Produto Controlado

CAS: 73232-52-7

Applications A labelled metabolite of Naltrexone (N285750). Methylnaltrexone (MNTX), a selective μ-opioid receptor antagonist, functions as a peripherally acting receptor antagonist in tissues of the gastrointestinal tract.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Wall, M., et al.: Drug Metab. Dispos., 12, 677 (1984), Jones, D., et al.: .: Bioorg. Med. Chem., 13, 6727 ( 2005), Chen, T., et al.: Drugs Future, 32, 771 (2007),

Fórmula: C₂₁H₂₃D₃BrNO₄

Cor e Forma: Neat

Peso molecular: 439.36

Ref: TR-M320352

N-Methyl Naltrexone Bromide

Produto Controlado

CAS: 73232-52-7

Stability Hygroscopic
Applications A metabolite of Naltrexone (N285750). Methylnaltrexone (MNTX; M320350), a selective μ-opioid receptor (MOR) antagonist, functions as a peripherally acting receptor antagonist in tissues of the gastrointestinal tract. When opiates activate μ-opioid receptors (MORs) they trigger signaling pathways that lead to tolerance and hyperalgesia. Methylnaltrexone (M320350) is positively charged and therefore does not cross the blood brain barier. Mice given morphine with methylnaltrexone experienced pain relief without degeloping tolerance.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Wall, M., et al.: Drug Metab. Dispos., 12, 677 (1984), Jones, D., et al.: .: Bioorg. Med. Chem., 13, 6727 ( 2005), Chen, T., et al.: Drugs Future, 32, 771 (2007); Chem. and Eng. News p.4 Jan. 23, (2017)

Fórmula: C₂₁H₂₆BrNO₄

Cor e Forma: Neat

Peso molecular: 436.35

Ref: TR-M320350

N-Methyl naltrexone bromide

Produto Controlado

CAS: 73232-52-7

N-Methyl naltrexone bromide is an opioid antagonist that binds to opioid receptors, preventing the binding of other opioid agonists. It has been shown to be effective in long-term treatment of chronic pain and may be used in combination with opioids for patients with hepatic impairment. The efficacy of N-methyl naltrexone bromide in treating constipation has not been established. This drug should not be used in patients with HIV infection because it may reduce the effectiveness of antiretroviral therapy. The pharmacokinetics and safety profile of this drug have been studied extensively, which showed no serious adverse effects. Histological analysis revealed that N-methyl naltrexone bromide did not affect epithelial mesenchymal cells or the intestinal villi.

Fórmula: C₂₁H₂₆BrNO₄

Pureza: Min. 95%

Peso molecular: 436.34 g/mol

Ref: 3D-FM25532

Methylnaltrexone Bromide

CAS: 73232-52-7

Fórmula: C₂₁H₂₆BrNO₄

Pureza: >95.0%(HPLC)(qNMR)

Cor e Forma: White to Light yellow powder to crystal

Peso molecular: 436.35

Ref: 3B-M3504