CAS 73554-84-4

tert-(Butiloxicarbonil)-L-valil-L-leucil-L-lisina-7-amino-4-metilcumarina

Descrição:

tert-(Butiloxicarbonil)-L-valil-L-leucil-L-lisina-7-amino-4-metilcumarina, comumente referido como um derivado peptídico, é caracterizado por sua estrutura complexa que inclui um grupo protetor de carbamato de tert-butilo (Boc), que é frequentemente utilizado na síntese de peptídeos para proteger grupos amino. A presença de L-valina, L-leucina e L-lisina indica que é um peptídeo sintético composto por esses aminoácidos, contribuindo para sua atividade biológica e potenciais aplicações no desenvolvimento de medicamentos. O grupo de 7-amino-4-metilcumarina serve como uma etiqueta fluorescente, tornando este composto útil em ensaios bioquímicos e estudos envolvendo interações peptídicas. Este composto é tipicamente solúvel em solventes orgânicos e pode exibir reatividade específica com base em seus grupos funcionais. Sua estabilidade e reatividade podem ser influenciadas por condições ambientais, como pH e temperatura. No geral, esta substância é significativa nos campos da química medicinal e bioquímica, particularmente no desenvolvimento de terapias baseadas em peptídeos e sondas fluorescentes.

Fórmula: C₃₂H₄₉N₅O₇

InChI: InChI=1S/C32H49N5O7/c1-18(2)15-24(36-30(41)27(19(3)4)37-31(42)44-32(6,7)8)29(40)35-23(11-9-10-14-33)28(39)34-21-12-13-22-20(5)16-26(38)43-25(22)17-21/h12-13,16-19,23-24,27H,9-11,14-15,33H2,1-8H3,(H,34,39)(H,35,40)(H,36,41)(H,37,42)/t23-,24-,27-/m0/s1

Chave InChI: InChIKey=KVLPXRKIIFWZLM-DPZBCOQUSA-N

SMILES: CC=1C=2C(=CC(NC([C@@H](NC([C@@H](NC([C@@H](NC(OC(C)(C)C)=O)[C@@H](C)C)=O)CC(C)C)=O)CCCCN)=O)=CC2)OC(=O)C1

Sinónimos:

• 7: PN: WO2004106541 PAGE: 15 claimed protein
• <span class="text-smallcaps">L</smallcap>-Lysinamide, N-[(1,1-dimethylethoxy)carbonyl]-<smallcap>L</smallcap>-valyl-<smallcap>L</span>-leucyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-
• Boc-Val-Leu-Lys-AMC
• Boc-Val-Leu-Lys-Amc Acetate
• N-(tert-butoxycarbonyl)-L-valyl-L-leucyl-N-(4-methyl-2-oxo-2H-chromen-7-yl)-L-lysinamide
• N-[(1,1-Dimethylethoxy)carbonyl]-<span class="text-smallcaps">L</smallcap>-valyl-<smallcap>L</smallcap>-leucyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-<smallcap>L</span>-lysinamide
• tert-(Butyloxycarbonyl)-<span class="text-smallcaps">L</smallcap>-valyl-<smallcap>L</smallcap>-leucyl-<smallcap>L</span>-lysine-7-amino-4-methylcoumarin
• tert-(Butyloxycarbonyl)-L-valyl-L-leucyl-L-lysine-7-amino-4-methylcoumarin
• N-[(1,1-Dimethylethoxy)carbonyl]-L-valyl-L-leucyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-L-lysinamide
• L-Lysinamide, N-[(1,1-dimethylethoxy)carbonyl]-L-valyl-L-leucyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-

Boc-Val-Leu-Lys-AMC

CAS: 73554-84-4

A sensitive, fluorogenic, and specific substrate for the quantitative measurement of plasmin. Boc-VLK-AMC is also cleaved by acrosin from the ascidian Halocynthia roretzi, by porcine calpain isozymes I and II, and by papain.

Fórmula: C₃₂H₄₉N₅O₇

Pureza: 97.7%

Cor e Forma: White Lyophilisate

Peso molecular: 615.77

Ref: 01-4004467

Boc-Val-Leu-Lys-AMC

CAS: 73554-84-4

Boc-Val-Leu-Lys-AMC is a research tool that has been shown to activate ion channels and increase the permeability of cell membranes. This compound also binds to receptors on cells, which may be due to its ability to bind with antibodies. Boc-Val-Leu-Lys-AMC has been used as an inhibitor in protein interactions and pharmacology studies, as well as for the study of ion channels in cell biology.

Fórmula: C₃₂H₄₉N₅O₇

Pureza: Min. 95%

Peso molecular: 615.76 g/mol

Ref: 3D-MVL-3104-V

Boc-Val-Leu-Lys-AMC acetate salt

CAS: 73554-84-4

Boc-Val-Leu-Lys-AMC acetate salt is a protease inhibitor that binds to the active site of trypsin and inhibits its proteolytic activity. It has been shown to protect neuronal cells from death caused by amyloid beta (Aβ) peptide. Boc-Val-Leu-Lys-AMC acetate salt also inhibits the secretion of proinflammatory cytokines and reduces the permeability of mitochondrial membranes in human neutrophils. This drug is stable in acidic environments, with a pH optimum of 2.0, but is sensitive to alkaline conditions with a pH optimum of 8.5. Boc-Val-Leu-Lys-AMC acetate salt has been shown to bind to casein, which may result in high values on sephadex g100 chromatography.

Fórmula: C₃₂H₄₉N₅O₇•C₂H₄O₂

Pureza: Min. 98 Area-%

Cor e Forma: Powder

Peso molecular: 675.81 g/mol

Ref: 3D-FB110487