CAS 73573-88-3

Mevastatina

Descrição:

Mevastatina, também conhecido como compactina, é uma estatina que ocorre naturalmente e é usada principalmente por suas propriedades de redução do colesterol. É derivada da fermentação de certos fungos, particularmente Penicillium citrinum. A estrutura química de Mevastatina apresenta um anel de lactona e um grupo ácido hidroxílico, que são cruciais para sua atividade biológica. Como inibidor da HMG-CoA redutase, Mevastatina desempenha um papel significativo na via do mevalonato, reduzindo efetivamente a síntese de colesterol no fígado. Essa ação ajuda a diminuir os níveis de colesterol de lipoproteína de baixa densidade (LDL) na corrente sanguínea, reduzindo assim o risco de doenças cardiovasculares. Mevastatina é tipicamente administrado em sua forma ativa, que é o ácido hidroxílico, uma vez que a forma de lactona é convertida na forma ativa no corpo. Embora tenha sido utilizado em pesquisas e tenha uma importância histórica no desenvolvimento de medicamentos estatinas, seu uso clínico foi em grande parte substituído por estatinas mais potentes e amplamente estudadas. Assim como com todos os medicamentos, potenciais efeitos colaterais e interações devem ser considerados ao avaliar seu uso.

Fórmula: C₂₃H₃₄O₅

InChI: InChI=1S/C23H34O5/c1-4-14(2)23(26)28-20-7-5-6-16-9-8-15(3)19(22(16)20)11-10-18-12-17(24)13-21(25)27-18/h6,8-9,14-15,17-20,22,24H,4-5,7,10-13H2,1-3H3/t14-,15-,17+,18+,19-,20-,22-/m0/s1

Chave InChI: InChIKey=AJLFOPYRIVGYMJ-INTXDZFKSA-N

SMILES: C(C[C@@H]1C[C@@H](O)CC(=O)O1)[C@@H]2[C@]3([C@@H](OC([C@H](CC)C)=O)CCC=C3C=C[C@@H]2C)[H]

Sinónimos:

• (1S,7S,8S,8aR)-8-{2-[(2R,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl]ethyl}-7-methyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl (2S)-2-methylbutanoate
• 2-Methyl-butanoic acid [1S-[1-alpha(R*),7-beta,8-beta(2S*,4S*),8a-beta]]-1,2,3,7,8,8a-hexahydro-7-methyl-8-[2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl]-1-naphthalenyl ester
• Antibiotic ML 236B
• Butanoic acid, 2-methyl-, (1S,7S,8S,8aR)-1,2,3,7,8,8a-hexahydro-7-methyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl ester, (2S)-
• Butanoic acid, 2-methyl-, 1,2,3,7,8,8a-hexahydro-7-methyl-8-[2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl]-1-naphthalenyl ester, [1S-[1α(R*),7β,8β(2S*,4S*),8aβ]]-
• CS 500 (antibiotic)
• Compactin (Penicillium)
• Cs 500
• L 637312
• ML 236B lactone
• Mevastatin
• Ml-236B
• NSC 281245
• Statin I

Mevastatin

CAS: 73573-88-3

Fórmula: C₂₃H₃₄O₅

Pureza: >98.0%(HPLC)

Cor e Forma: White to Yellow to Orange powder to crystal

Peso molecular: 390.52

Ref: 3B-M2275

Mevastatin, 98%

CAS: 73573-88-3

Mevastatin (Compactin) inhibits HMGCR (HMG-CoA reductase) , induces apoptosis which in turn inhibits isoprenoid biosynthesis and therefore blocks protein isoprenylation and reduces plasma cholesterol levels in humans. Mevastatin causes cells to arrest early in the G1 phase. Mevastatin is a close str

Fórmula: C₂₃H₃₄O₅

Pureza: 98%

Cor e Forma: Powder or crystals or crystalline powder

Peso molecular: 390.52

Ref: 02-J61357

Mevastatin ((1S,7S,8S,8aR)-8-{2-[(2R,4R)-4-Hydroxy-6-oxotetrahydro-2H-pyran-2-yl]ethyl}-7-methyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl (S)-2-methylbutanoate)

CAS: 73573-88-3

Lactones, nesoi

Fórmula: C₂₃H₃₄O₅

Cor e Forma: Yellow Pale Yellow Powder

Peso molecular: 390.24062

Ref: 45-1443216

Mevastatin

CAS: 73573-88-3

Mevastatin (ML236B) is an HMG-CoA reductase inhibitor that was initially isolated from the mold Pythium ultimum.

Fórmula: C₂₃H₃₄O₅

Pureza: 99.12%

Cor e Forma: White-Yellowish To Yellow Powder Solid Powder

Peso molecular: 390.51

Ref: TM-T0683

Butanoic acid, 2-methyl-, (1S,7S,8S,8aR)-1,2,3,7,8,8a-hexahydro-7-methyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl ester, (2S)-

CAS: 73573-88-3

Fórmula: C₂₃H₃₄O₅

Pureza: 95%

Cor e Forma: Solid

Peso molecular: 390.5131

Ref: IN-DA0038GT

Mevastatin

CAS: 73573-88-3

Fórmula: C₂₃H₃₄O₅

Pureza: ≤ 0.5%

Cor e Forma: White to light-yellow crystalline powder

Peso molecular: 390.52

Ref: 7W-GA8933

Mevastatin

CAS: 73573-88-3

Mevastatin

Pureza: 98%

Peso molecular: 390.51g/mol

Ref: 54-OR1030263

Mevastatin

CAS: 73573-88-3

Mevastatin

Pureza: ≥95%

Peso molecular: 390.51g/mol

Ref: 54-BUP14954

Mevastatin (Compactin)

CAS: 73573-88-3

Fórmula: C₂₃H₃₄O₅

Cor e Forma: White To Off-White Solid

Peso molecular: 390.52

Ref: 4Z-M-691

Mevastatin

Produto Controlado

CAS: 73573-88-3

Fórmula: C₂₃H₃₄O₅

Cor e Forma: Neat

Peso molecular: 390.51

Ref: 86-MM0377.00

Mevastatin

CAS: 73573-88-3

Fórmula: C₂₃H₃₄O₅

Cor e Forma: Neat

Peso molecular: 390.51

Ref: 04-C15219000

Mevastatin

Produto Controlado

CAS: 73573-88-3

Applications A fungal metabolite which is a potent inhibitor of HMG-CoA reductase.
References Endo, A., et al.: FEBS Letters, 72, 323 (1976), Endo, A.: J. Med. Chem., 28, 401 (1985)

Fórmula: C₂₃H₃₄O₅

Cor e Forma: White To Off-White

Peso molecular: 390.51

Ref: TR-M340500

Mevastatin - Bio-X ™

CAS: 73573-88-3

Mevastatin is a drug that inhibits the synthesis of cholesterol and has been used to treat hypercholesterolemia. It binds to the hydroxyl group at position 3 on the mevalonate molecule, which prevents the formation of 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) and consequently reduces the production of cholesterol. Mevastatin has been shown to inhibit mitochondrial functions in wild-type strain yeast cells and myeloma cell lines, which may be due to receptor activity.

Fórmula: C₂₃H₃₄O₅

Pureza: Min. 98 Area-%

Cor e Forma: Powder

Peso molecular: 390.51 g/mol

Ref: 3D-BM164666

Mevastatin

CAS: 73573-88-3

Mevastatin is a drug that inhibits the synthesis of cholesterol and has been used to treat hypercholesterolemia. It binds to the hydroxyl group at position 3 on the mevalonate molecule, which prevents the formation of 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) and consequently reduces the production of cholesterol. Mevastatin has been shown to inhibit mitochondrial functions in wild-type strain yeast cells and myeloma cell lines, which may be due to receptor activity. In addition, it has been shown to induce neuronal death in a polymerase chain reaction assay by inhibiting DNA synthesis.

Fórmula: C₂₃H₃₄O₅

Pureza: Min. 95%

Cor e Forma: Powder

Peso molecular: 390.51 g/mol

Ref: 3D-FM25991

Mevastatin

CAS: 73573-88-3

M02108 - Mevastatin

Fórmula: C₂₃H₃₄O₅

Pureza: 95%

Cor e Forma: Solid

Peso molecular: 390.52

Ref: 10-M02108

Pravastatin Deshydroxy Impurity

CAS: 73573-88-3

Fórmula: C₂₃H₃₄O₅

Peso molecular: 390.52

Ref: ST-EA-CP-P52009