CAS 74863-84-6

Argatroban

Descrição:

Argatroban é um inibidor sintético direto da trombina usado principalmente como anticoagulante em ambientes clínicos, particularmente para pacientes com trombocitopenia induzida por heparina (HIT). É uma pequena molécula que se liga seletivamente ao sítio ativo da trombina, impedindo a conversão de fibrinogênio em fibrina, que é crucial no processo de coagulação. Argatroban é administrado por via intravenosa e tem um início de ação rápido, tornando-o adequado para situações agudas. Sua farmacocinética é caracterizada por uma meia-vida curta, necessitando de infusão contínua para anticoagulação sustentada. A substância é metabolizada principalmente no fígado, e seus efeitos podem ser monitorados usando testes de tempo de tromboplastina parcial ativada (aPTT). Efeitos colaterais comuns incluem complicações hemorrágicas, que são um risco associado a todos os anticoagulantes. Argatroban também é notável por sua falta de reatividade cruzada com heparina, tornando-o uma escolha preferida para pacientes com histórico de HIT. No geral, seu mecanismo e propriedades únicos fazem dele um agente terapêutico importante no manejo de distúrbios trombóticos.

Fórmula: C₂₃H₃₆N₆O₅S

InChI: InChI=1S/C23H36N6O5S/c1-14-8-10-29(18(12-14)22(31)32)21(30)17(6-4-9-26-23(24)25)28-35(33,34)19-7-3-5-16-11-15(2)13-27-20(16)19/h3,5,7,14-15,17-18,27-28H,4,6,8-13H2,1-2H3,(H,31,32)(H4,24,25,26)/t14-,15?,17+,18-/m1/s1

Chave InChI: InChIKey=KXNPVXPOPUZYGB-IOVMHBDKSA-N

SMILES: S(N[C@H](C(=O)N1[C@@H](C(O)=O)C[C@H](C)CC1)CCCNC(=N)N)(=O)(=O)C2=C3C(=CC=C2)CC(C)CN3

Sinónimos:

• (2R,4R)-1-[(2S)-5-(diaminomethylideneamino)-2-[[(3R)-3-methyl-1,2,3,4-tetrahydroquinolin-8-yl]sulfonylamino]pentanoyl]-4-methyl-piperidine-2-carboxylic acid
• (2R,4R)-1-[(2S)-5-[(Aminoiminomethyl)amino]-1-oxo-2-[[(1,2,3,4-tetrahydro-3-methyl-8-quinolinyl)sulfonyl]amino]pentyl]-4-methyl-2-piperidinecarboxylic acid
• (2R,4R)-1-[N2-3-(methyl-1,2,3,4-tetrahydro-8-quinolinesulfonyl)-L-arginyl]-4-methyl-2-piperidinecarboxylic acid monohydrate
• (2R,4R)-1-[N~5~-(diaminomethylidene)-N~2~-{[(3R)-3-methyl-1,2,3,4-tetrahydroquinolin-8-yl]sulfonyl}-L-ornithyl]-4-methylpiperidine-2-carboxylic acid
• (2R,4R)-1-{N~5~-(diaminomethylidene)-N~2~-[(3-methyl-1,2,3,4-tetrahydroquinolin-8-yl)sulfonyl]-L-ornithyl}-4-methylpiperidine-2-carboxylic acid
• (2R,4R)-1-{N~5~-(diaminomethylidene)-N~2~-[(3-methyl-1,2,3,4-tetrahydroquinolin-8-yl)sulfonyl]ornithyl}-4-methylpiperidine-2-carboxylic acid
• (2R,4R)-4-Methyl-1-[N-[(3-Methyl-1,2,3,4-Tetrahydro-8-Quinolinyl)Sulfonyl]-L-Arginyl]-2-Piperidinecarboxylic Acid
• 2-Piperidinecarboxylic acid, 1-(5-((aminoiminomethyl)amino)-1-oxo-2-(((1,2,3,4-tetrahydro-3-methyl-8-quinolinyl)sulfonyl)amino)pentyl)-4-methyl-, (2R-(1(S*(R*)),2alpha,4beta))-
• 2-Piperidinecarboxylic acid, 1-[(2S)-5-[(aminoiminomethyl)amino]-1-oxo-2-[[(1,2,3,4-tetrahydro-3-methyl-8-quinolinyl)sulfonyl]amino]pentyl]-4-methyl-, (2R,4R)-
• 2-Piperidinecarboxylic acid, 1-[5-[(aminoiminomethyl)amino]-1-oxo-2-[[(1,2,3,4-tetrahydro-3-methyl-8-quinolinyl)sulfonyl]amino]pentyl]-4-methyl-, [2R-[1(2S*),2α,4β]]-[partial]-
• 21R-
• Acova
• Argatra
• Argatroban
• Argatroban Monohydrate
• Argipidin
• Argipidine
• Dk 7419
• Gn 1600
• Gn1600
• Mci 9038
• Md 805
• Novastan
• Om 805
• Slonnon

Argatroban Monohydrate

CAS: 141396-28-3, 74863-84-6

Fórmula: C₂₃H₃₆N₆O₅S·H₂O

Pureza: >99.0%(HPLC)

Cor e Forma: White to Almost white powder to crystal

Peso molecular: 526.66

Ref: 3B-A2705

(2R,4R)-1-[(2S)-5-[(diaminomethylidene)amino]-2-[(3R)-3-methyl-1,2,3,4-tetrahydroquinoline-8-sulfonamido]pentanoyl]-4-methylpiperidine-2-carboxylic acid

CAS: 74863-84-6

Fórmula: C₂₃H₃₆N₆O₅S

Pureza: 98%

Cor e Forma: Solid

Peso molecular: 508.6341

Ref: IN-DA0038G0

Argatroban (Mixture of Diastereomers)

CAS: 74863-84-6

Fórmula: C₂₃H₃₆N₆O₅S

Cor e Forma: White To Off-White Solid

Peso molecular: 508.64

Ref: 4Z-A-591

Argatroban

CAS: 74863-84-6

Argatroban

Pureza: ≥98%

Peso molecular: 508.63g/mol

Ref: 54-BUP15629

Argatroban

CAS: 74863-84-6

Fórmula: C₂₃H₃₈N₆O₆S

Pureza: (HPLC) ≥ 98%

Cor e Forma: White to off-white powder

Peso molecular: 526.65

Ref: 7W-GP6176

Argatroban

CAS: 74863-84-6

Argatroban (MCI-9038), a specific thrombin inhibitor, which is a non-heparin anticoagulant, prevents the formation of thrombi.

Fórmula: C₂₃H₃₆N₆O₅S

Pureza: 99.77% - >99.99%

Cor e Forma: White To Off-White Crystalline Solid

Peso molecular: 508.63

Ref: TM-T0155

Argatroban

Produto Controlado

CAS: 74863-84-6

Applications Synthetic thrombin inhibitor. Antithrombotic.
References Abiko, Y., et al.: Thromb. Res., 24, 285 (1981), Kikumoto, R., et al.: Biochemistry, 23, 85 (1984),

Fórmula: C₂₃H₃₆N₆O₅S

Cor e Forma: White Powder

Peso molecular: 508.63

Ref: TR-A769000

Argatroban

CAS: 74863-84-6

Argatroban is a drug that belongs to the group of anticoagulants and is used in the treatment of blood disorders. Argatroban is an oral prodrug that undergoes hepatic metabolism to its active form, argatroban. Argatroban is a thrombin inhibitor that competes with heparin for binding to antithrombin III and thrombin, thereby preventing the formation of fibrin clots. Argatroban has been shown to be successful in treating patients with congestive heart failure or nephrology dialysis who are at risk for developing deep vein thrombosis. This drug also has a long half-life and does not require frequent monitoring, making it suitable for use in these patient populations. However, argatroban should not be used if there is hepatic impairment or if the patient has undergone recent cerebral surgery due to the risk of brain infarction.

Fórmula: C₂₃H₃₆N₆O₅S

Pureza: Min. 95%

Cor e Forma: Off-White Powder

Peso molecular: 508.64 g/mol

Ref: 3D-FA17976