CAS 7542-37-2

Paromomicina

Descrição:

Paromomicina é um antibiótico aminoglicosídeo usado principalmente para tratar infecções causadas por certos parasitas e bactérias. É derivado da bactéria Streptomyces griseus e é particularmente eficaz contra infecções protozoárias, como leishmaniose e amebíase. Paromomicina atua ligando-se à subunidade ribossômica 30S das bactérias, inibindo a síntese de proteínas, o que leva à morte celular bacteriana. O composto é caracterizado por sua toxicidade relativamente baixa em comparação com outros aminoglicosídeos, tornando-o adequado para uso em populações específicas, incluindo mulheres grávidas para certas infecções. Paromomicina é tipicamente administrado por via oral ou intramuscular, dependendo da condição a ser tratada. Sua solubilidade em água permite fácil formulação em várias preparações farmacêuticas. No entanto, é importante monitorar possíveis efeitos colaterais, incluindo distúrbios gastrointestinais e nefrotoxicidade, especialmente em pacientes com condições renais preexistentes. No geral, Paromomicina continua sendo um agente terapêutico valioso no tratamento de doenças infecciosas específicas.

Fórmula: C₂₃H₄₅N₅O₁₄

InChI: InChI=1S/C23H45N5O14/c24-2-7-13(32)15(34)10(27)21(37-7)41-19-9(4-30)39-23(17(19)36)42-20-12(31)5(25)1-6(26)18(20)40-22-11(28)16(35)14(33)8(3-29)38-22/h5-23,29-36H,1-4,24-28H2/t5-,6+,7+,8-,9-,10-,11-,12+,13-,14-,15-,16-,17-,18-,19-,20-,21-,22-,23+/m1/s1

Chave InChI: InChIKey=UOZODPSAJZTQNH-LSWIJEOBSA-N

SMILES: O([C@H]1[C@H](O[C@H]2[C@H](O)[C@H](O[C@H]3O[C@@H](CN)[C@@H](O)[C@H](O)[C@H]3N)[C@@H](CO)O2)[C@@H](O)[C@H](N)C[C@@H]1N)[C@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4N

Sinónimos:

• (1R,2R,3S,4R,6S)-4,6-Diamino-2-{[3-O-(2,6-diamino-2,6-dideoxy-beta-L-idopyranosyl)-beta-D-ribofuranosyl]oxy}-3-hydroxycyclohexyl 2-amino-2-deoxy-alpha-D-glucopyranoside
• 231-423-0
• <span class="text-smallcaps">D</smallcap>-Streptamine, O-2,6-diamino-2,6-dideoxy-β-<smallcap>L</smallcap>-idopyranosyl-(1→3)-O-β-<smallcap>D</smallcap>-ribofuranosyl-(1→5)-O-[2-amino-2-deoxy-α-<smallcap>D</span>-glucopyranosyl-(1→4)]-2-deoxy-
• <span class="text-smallcaps">D</smallcap>-Streptamine, O-2-amino-2-deoxy-α-<smallcap>D</smallcap>-glucopyranosyl-(1→4)-O-[O-2,6-diamino-2,6-dideoxy-β-<smallcap>L</smallcap>-idopyranosyl-(1→3)-β-<smallcap>D</span>-ribofuranosyl-(1→5)]-2-deoxy-
• Aminosidin
• Aminosidine
• Aminosidine I
• Amminosidin
• Antibiotic 2230D
• Antibiotic 503-3
• Antibiotic SF 767B
• Catenulin
• Crestomycin
• D-Streptamine, O-2,6-diamino-2,6-dideoxy-β-L-idopyranosyl-(1→3)-O-β-D-ribofuranosyl-(1→5)-O-[2-amino-2-deoxy-α-D-glucopyranosyl-(1→4)]-2-deoxy-
• D-Streptamine, O-2-amino-2-deoxy-α-D-glucopyranosyl-(1→4)-O-[O-2,6-diamino-2,6-dideoxy-β-L-idopyranosyl-(1→3)-β-D-ribofuranosyl-(1→5)]-2-deoxy-
• Gabbromicina
• Gabbromycin
• Gabromycin
• Humycin
• Hydroxymycin
• Monomycin A
• Neomycin E
• O-2,6-Diamino-2,6-dideoxy-β-<span class="text-smallcaps">L</smallcap>-idopyranosyl-(1→3)-O-β-<smallcap>D</smallcap>-ribofuranosyl-(1→5)-O-[2-amino-2-deoxy-α-<smallcap>D</smallcap>-glucopyranosyl-(1→4)]-2-deoxy-<smallcap>D</span>-streptamine
• Paromomicina
• Paromomycin I
• Paromomycine
• Paucimycin
• Quintomycin C
• R 400
• Streptamine, O-2,6-diamino-2,6-dideoxy-β-<span class="text-smallcaps">L</smallcap>-idopyranosyl-(1→3)-O-β-<smallcap>D</smallcap>-ribofuranosyl-(1→5)-O-[2-amino-2-deoxy-α-<smallcap>D</span>-glucopyranosyl-(1→4)]-2-deoxy-
• Streptamine, O-2,6-diamino-2,6-dideoxy-β-L-idopyranosyl-(1→3)-O-β-D-ribofuranosyl-(1→5)-O-[2-amino-2-deoxy-α-D-glucopyranosyl-(1→4)]-2-deoxy-
• Zygomycin A1
• Zygomycin A₁

Paromomycin Sulfate

CAS: 1263-89-4, 7542-37-2, 84420-34-8

Fórmula: C₂₃H₄₅N₅O₁₄·xH₂SO₄

Pureza: >92.0%(HPLC)

Cor e Forma: White to Almost white powder to crystal

Ref: 3B-P2092

Paromomycin Deuterated Acetic Acid Salt

Produto Controlado

CAS: 7542-37-2

Applications Paromomycin Deuterated Acetic Acid Salt is the isotope labelled analog of Paromomycin Sulfate. Paromomycin Sulfate is an aminogycoside antibiotic designed to fight intestinal infections such as cryptosporidiosis, amoebiasis, and leishmaniasis. Its antiprotozoal activity makes it an effecive histomonostatic feed additive in turkey poults experimentally infected with Histomonas meleagridis.
References Rehg, J.E. et al.: J. Infect. Dis., 170, 934 (1994); Fong, D. et al.: Am. J. Trop. Med. Hyg., 51, 758 (1994); Hafez, H.M. et al.: Arch. Anim. Nut., 64, 77 (2010);

Fórmula: C₂₃H₄₅N₅O₁₄•5(CH₃COOH)forundeuterated

Cor e Forma: Neat

Peso molecular: 615.63

Ref: TR-P205653

Aminosidine

CAS: 7542-37-2

Aminosidine is a nucleoside analogue that inhibits the HIV-1 reverse transcriptase and the integrase, which are enzymes involved in viral DNA synthesis. Aminosidine is active against Leishmania spp., but not against bacteria. Aminosidine has been shown to be effective in experimental models of human bowel disease and in patients with inflammatory bowel disease. It was also found to be active against wild-type strains of human immunodeficiency virus type 1, but not resistant mutants. The mechanism of action is the inhibition of cellular mitochondrial membrane potential.

Pureza: Min. 95%

Ref: 3D-OA11590

Neomycin EP Impurity E

CAS: 7542-37-2

Fórmula: C₂₃H₄₅N₅O₁₄

Peso molecular: 615.63

Ref: ST-EA-CP-N53012