CAS 75443-99-1

Ácido naftacenocarboxílico, 2-etil-1,2,3,4,6,11-hexahidro-2,5,7-triidroxi-6,11-dioxo-4-[[2,3,6-trideoxi-4-O-[2,6-dideoxi-4-O-[(2R,6S)-tetraidro-6-metil-5-oxo-2H-pirano-2-il]-α-L-lixo-hexopiranosil]-3-(dimetilamino)-α-L-lixo-hexopiranosil]oxi]-, éster metílico, cloridrato (1:1), (1R,2R,4S)-

Descrição:

Ácido naftacenocarboxílico, 2-etil-1,2,3,4,6,11-hexahidro-2,5,7-triidroxi-6,11-dioxo-4-[[2,3,6-trideoxi-4-O-[2,6-dideoxi-4-O-[(2R,6S)-tetraidro-6-metil-5-oxo-2H-pirano-2-il]-α-L-lixo-hexopiranosil]-3-(dimetilamino)-α-L-lixo-hexopiranosil]oxi]-, éster metílico, cloridrato (1:1), (1R,2R,4S)-, identificado pelo número CAS 75443-99-1, é um composto orgânico complexo caracterizado por sua intrincada estrutura molecular, que inclui múltiplos grupos funcionais como ácidos carboxílicos, hidroxilas e ésteres. Este composto exibe propriedades típicas de derivados de naftaleno e estruturas semelhantes a carboidratos, sugerindo uma potencial atividade biológica. Sua forma de cloridrato indica que é um sal, o que pode aumentar sua solubilidade em soluções aquosas. A presença de múltiplos estereocentros implica que pode existir em diferentes formas estereoisoméricas, o que pode influenciar sua reatividade e interação com sistemas biológicos. No geral, a estrutura única deste composto pode contribuir para suas potenciais aplicações em farmacêutica ou bioquímica, embora atividades biológicas específicas e aplicações exijam investigação adicional.

Fórmula: C₄₂H₅₃NO₁₅·ClH

InChI: InChI=1S/C42H53NO15.ClH/c1-8-42(51)17-28(33-22(35(42)41(50)52-7)14-23-34(38(33)49)37(48)32-21(36(23)47)10-9-11-26(32)45)56-30-15-24(43(5)6)39(19(3)54-30)58-31-16-27(46)40(20(4)55-31)57-29-13-12-25(44)18(2)53-29;/h9-11,14,18-20,24,27-31,35,39-40,45-46,49,51H,8,12-13,15-17H2,1-7H3;1H/t18-,19-,20-,24-,27-,28-,29-,30-,31-,35-,39+,40+,42+;/m0./s1

Chave InChI: InChIKey=KUSMIBXCRZTVML-PCCPLWKKSA-N

SMILES: C(OC)(=O)[C@@H]1C2=C([C@@H](O[C@H]3C[C@H](N(C)C)[C@H](O[C@H]4C[C@H](O)[C@H](O[C@@H]5O[C@@H](C)C(=O)CC5)[C@H](C)O4)[C@H](C)O3)C[C@@]1(CC)O)C(O)=C6C(=C2)C(=O)C=7C(C6=O)=C(O)C=CC7.Cl

Sinónimos:

• 1-Naphthacenecarboxylic acid, 1,2,3,4,6,11-hexahydro-6,11-dioxo-2-ethyl-4-((2,3,6-trideoxy-4-O-(2,6-dideoxy-4-O-((2R-trans)-tetrahydro-6-methyl-5-oxo-2H-pyran-2-yl)-alpha-L-lyxo-hexopyranosyl)-3-(dimethylamino)-alpha-L-lyxo-hexopyranosyl)oxy)-2,5,7-trihydroxy-, methyl ester, hydrochloride, (1R-(1-alpha,2-beta,4-beta))-
• 1-Naphthacenecarboxylic acid, 2-ethyl-1,2,3,4,6,11-hexahydro-2,5,7-trihydroxy-6,11-dioxo-4-((2,3,6-trideoxy-4-O-(2,6-dideoxy-4-O-((2R-trans)-tetrahydro-6-methyl-5-oxo-2H-pyran-2-yl)-alpha-l-lyxo-hexopyranosyl)-3-(dimethylamino)-alpha-l-lyxo-hexopyranosyl)oxy)-, methyl ester, hydrochloride, (1R-(1alpha,2beta,4beta))-
• 1-Naphthacenecarboxylic acid, 2-ethyl-1,2,3,4,6,11-hexahydro-2,5,7-trihydroxy-6,11-dioxo-4-[[2,3,6-trideoxy-4-O-[2,6-dideoxy-4-O-[(2R,6S)-tetrahydro-6-methyl-5-oxo-2H-pyran-2-yl]-α-<span class="text-smallcaps">L</smallcap>-lyxo-hexopyranosyl]-3-(dimethylamino)-α-<smallcap>L</span>-lyxo-hexopyranosyl]oxy]-, methyl ester, hydrochloride (1:1), (1R,2R,4S)-
• 1-Naphthacenecarboxylic acid, 2-ethyl-1,2,3,4,6,11-hexahydro-2,5,7-trihydroxy-6,11-dioxo-4-[[2,3,6-trideoxy-4-O-[2,6-dideoxy-4-O-[(2R,6S)-tetrahydro-6-methyl-5-oxo-2H-pyran-2-yl]-α-<span class="text-smallcaps">L</smallcap>-lyxo-hexopyranosyl]-3-(dimethylamino)-α-<smallcap>L</span>-lyxo-hexopyranosyl]oxy]-, methyl ester, hydrochloride, (1R,2R,4S)-
• 1-Naphthacenecarboxylic acid, 2-ethyl-1,2,3,4,6,11-hexahydro-2,5,7-trihydroxy-6,11-dioxo-4-[[2,3,6-trideoxy-4-O-[2,6-dideoxy-4-O-[(2R-trans)-tetrahydro-6-methyl-5-oxo-2H-pyran-2-yl]-α-<span class="text-smallcaps">L</smallcap>-lyxo-hexopyranosyl]-3-(dimethylamino)-α-<smallcap>L</span>-lyxo-hexopyranosyl]oxy]-, methyl ester, hydrochloride, [1R-(1α,2β,4β)]-
• Aclacinomycin A hydrochloride
• Aclacinon
• Aclaplastin
• Aclarubicin HCl
• Aclarubicina clorhidrato
• Aclarubicina clorhidrato [Spanish]
• Unii-501948Ri66
• methyl (1R,2R,4S)-2-ethyl-2,5,7-trihydroxy-6,11-dioxo-4-{[2,3,6-trideoxy-4-O-{2,6-dideoxy-4-O-[(2R,6S)-6-methyl-5-oxotetrahydro-2H-pyran-2-yl]-alpha-L-lyxo-hexopyranosyl}-3-(dimethylamino)-alpha-L-lyxo-hexopyranosyl]oxy}-1,2,3,4,6,11-hexahydrotetracene-1-carboxylate hydrochloride (1:1)
• 1-Naphthacenecarboxylic acid, 2-ethyl-1,2,3,4,6,11-hexahydro-2,5,7-trihydroxy-6,11-dioxo-4-[[2,3,6-trideoxy-4-O-[2,6-dideoxy-4-O-[(2R,6S)-tetrahydro-6-methyl-5-oxo-2H-pyran-2-yl]-α-L-lyxo-hexopyranosyl]-3-(dimethylamino)-α-L-lyxo-hexopyranosyl]oxy]-, methyl ester, hydrochloride (1:1), (1R,2R,4S)-
• Aclarubicin hydrochloride
• 1-Naphthacenecarboxylic acid, 2-ethyl-1,2,3,4,6,11-hexahydro-2,5,7-trihydroxy-6,11-dioxo-4-[[2,3,6-trideoxy-4-O-[2,6-dideoxy-4-O-[(2R,6S)-tetrahydro-6-methyl-5-oxo-2H-pyran-2-yl]-α-L-lyxo-hexopyranosyl]-3-(dimethylamino)-α-L-lyxo-hexopyranosyl]oxy]-, methyl ester, hydrochloride, (1R,2R,4S)-

Aclacinomycin A hydrochloride

CAS: 75443-99-1

Aclacinomycin A hydrochloride

Pureza: ≥95%

Peso molecular: 848.33g/mol

Ref: 54-BUP21726

Aclacinomycin A hydrochloride

CAS: 75443-99-1

Aclacinomycin A hydrochloride (Aclarubicin HCl) is an antibiotic and inhibitor of topoisomerase I/II, interfering with DNA transcription and replication,

Fórmula: C₄₂H₅₄ClNO₁₅

Pureza: 98%

Cor e Forma: Solid

Peso molecular: 848.33

Ref: TM-T10238

Aclacinomycin hydrochloride

CAS: 75443-99-1

Ref: 7W-GC4572

Aclacinomycin HCl

CAS: 75443-99-1

Aclacinomycin HCl is a cytotoxic antibiotic that inhibits the growth of tumor cells. It has been shown to induce apoptosis in human leukemia cells by altering the transmembrane potential and inhibiting cell proliferation. Aclacinomycin HCl also induces DNA damage response, which leads to caspase activities and cell death. This drug is highly selective for tumor cells, with no effect on normal cells. It has been shown to be effective against primary liver cancer in animal models, as well as developmental disorders such as autism spectrum disorder (ASD).

Fórmula: C₄₂H₅₃NO₁₅·HCl

Pureza: Min. 95%

Cor e Forma: Orange Powder

Peso molecular: 848.33 g/mol

Ref: 3D-AA16417