CAS 75607-67-9

Fosfato de fludarabina

Descrição:

Fosfato de fludarabina é um agente antineoplásico usado principalmente no tratamento de certos tipos de leucemia, particularmente leucemia linfocítica crônica (LLC) e linfoma não-Hodgkin. É um análogo de purina, especificamente um derivado de adenosina, que interfere na síntese e reparo do DNA, levando à morte celular. O composto é tipicamente administrado por via intravenosa e é conhecido por sua capacidade de penetrar efetivamente nas membranas celulares devido à sua forma de éster fosfato, que aumenta sua solubilidade. Fosfato de fludarabina apresenta uma meia-vida relativamente curta, necessitando de dosagem e monitoramento cuidadosos durante o tratamento. Os efeitos colaterais comuns incluem mielossupressão, imunossupressão e distúrbios gastrointestinais. Seu mecanismo de ação envolve a inibição da DNA polimerase e da ribonucleotídeo redutase, interrompendo a proliferação de células malignas. Como agente quimioterápico, é frequentemente usado em combinação com outros medicamentos para aumentar a eficácia terapêutica. Devido aos seus efeitos potentes, Fosfato de fludarabina é classificado como um medicamento perigoso, exigindo manuseio e descarte adequados em ambientes clínicos.

Fórmula: C₁₀H₁₃FN₅O₇P

InChI: InChI=1S/C10H13FN5O7P/c11-10-14-7(12)4-8(15-10)16(2-13-4)9-6(18)5(17)3(23-9)1-22-24(19,20)21/h2-3,5-6,9,17-18H,1H2,(H2,12,14,15)(H2,19,20,21)/t3-,5-,6+,9-/m1/s1

Chave InChI: InChIKey=GIUYCYHIANZCFB-FJFJXFQQSA-N

SMILES: NC1=C2C(N(C=N2)[C@@H]3O[C@H](COP(=O)(O)O)[C@@H](O)[C@@H]3O)=NC(F)=N1

Sinónimos:

• 9-bata-D-Arabinofuranosyl-2-fluoroadenine phosphate
• 9H-Purin-6-amine, 2-fluoro-9-(5-O-phosphono-β-D-arabinofuranosyl)-
• 9-b-D-Arabinofuranosyl-2-fluoroadenine-5-(dihydrogen phosphate)
• 2-Fluoro-9-(5-O-phosphono-β-D-arabinofuranosyl)-9H-purin-6-amine
• Fludarabine phosphate
• Fludarabin Phosphate
• NSC 312887
• NSC 328002
• 9-beta-arabinofuranosyl-2-fluoroadenine-5'-phosphate
• 2-fluoro-9-(5-O-phosphono-beta-D-arabinofuranosyl)-9H-purin-6-amine
• 9-β-Arabinofuranosyl-2-fluoroadenine-5'-monophosphate
• 2-fluoro-9-(5-O-phosphonopentofuranosyl)-9H-purin-6-amine

Fludarabine Monophosphate

CAS: 75607-67-9

Fórmula: C₁₀H₁₃FN₅O₇P

Pureza: >98.0%(T)(HPLC)

Cor e Forma: White to Almost white powder to crystal

Peso molecular: 365.21

Ref: 3B-F0913

FLUDARABINE FOR SYSTEM SUITABILITY CRS

CAS: 75607-67-9

FLUDARABINE FOR SYSTEM SUITABILITY CRS

Ref: 41-Y0001536

Fludarabine phosphate

CAS: 75607-67-9

Fludarabine phosphate

Fórmula: C₁₀H₁₃FN₅O₇P

Pureza: 97.8%

Cor e Forma: White. To. Off-White

Peso molecular: 365.05366

Ref: 47-1321

FLUDARABINE PHOSPHATE CRS

CAS: 75607-67-9

FLUDARABINE PHOSPHATE CRS

Fórmula: C₁₀H₁₃FN₅O₇P

Cor e Forma: Added Added

Peso molecular: 365.2117

Ref: 41-Y0000419

FLUDARABINE FOR PEAK IDENTIFICATION CRS

CAS: 75607-67-9

FLUDARABINE FOR PEAK IDENTIFICATION CRS

Ref: 41-Y0002256

Fludarabine Phosphate

CAS: 75607-67-9

Nucleic acids and their salts, whether or not chemically defined; other heterocyclic compounds, nesoi

Fórmula: C₁₀H₁₃FN₅O₇P

Cor e Forma: White Crystalline Powder

Peso molecular: 365.05366

Ref: 45-1272204

{[(2R,3S,4S,5R)-5-(6-amino-2-fluoro-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}phosphonic acid

CAS: 75607-67-9

Fórmula: C₁₀H₁₃FN₅O₇P

Pureza: 98%

Cor e Forma: Solid

Peso molecular: 365.2117

Ref: IN-DA00ICN9

Fludarabine Phosphate

CAS: 75607-67-9

Fludarabine Phosphate

Pureza: 98%

Peso molecular: 365.21g/mol

Ref: 54-PC109175

Fludarabine Phosphate

CAS: 75607-67-9

Fludarabine Phosphate

Pureza: ≥98%

Peso molecular: 365.21g/mol

Ref: 54-BUP15559

Fludarabine Phosphate

CAS: 75607-67-9

Fórmula: C₁₀H₁₃FN₅O₇P

Cor e Forma: White To Off-White Solid

Peso molecular: 365.22

Ref: 4Z-F-588

Fludarabine phosphate, USP

CAS: 75607-67-9

Fórmula: C₁₀H₁₃FN₅O₇P

Pureza: ≤ 0.1%

Cor e Forma: White powder

Peso molecular: 365.21

Ref: 7W-GP3476

Fludarabine Phosphate

CAS: 75607-67-9

Cor e Forma: Neat

Ref: 86-MM3428.00

Fludarabine Phosphate

CAS: 75607-67-9

Fludarabine Phosphate (NSC 312887 Phosphate) is a fluorinated nucleotide antimetabolite analog of the antiviral agent vidarabine with antineoplastic activity.

Fórmula: C₁₀H₁₃FN₅O₇P

Pureza: 99.25% - 99.78%

Cor e Forma: Solid

Peso molecular: 365.21

Ref: TM-T6501

Fludarabine phosphate

CAS: 75607-67-9

Fórmula: C₁₀H₁₃FN₅O₇P

Pureza: ≥ 98.0%

Cor e Forma: White to almost white powder

Peso molecular: 365.21

Ref: 7W-GP0418

Fludarabine phosphate

CAS: 75607-67-9

Pureza: 98%

Peso molecular: 365.21

Ref: 10-F792862

Fludarabine Phosphate

Produto Controlado

CAS: 75607-67-9

Applications 4-Desfluoro-4-(1,2,4-triazol-1-yl)phenyl Fluconazole is an impurity in the synthesis of Fluconazole (F421000), used as an antifungal.
References Richard, K. et al.: Antimicrob. Ag. Chemother., 27, 832 (1985);

Fórmula: C₁₀H₁₃FN₅O₇P

Cor e Forma: White To Off-White

Peso molecular: 365.21

Ref: TR-F425005

Fludarabine phosphate

CAS: 75607-67-9

Fludarabine phosphate is an antileukemic drug that inhibits DNA polymerase α and β, as well as other enzymes in the nucleotide synthesis pathway. It is used to treat patients with chronic myelogenous leukemia (CML) who have developed resistance to other treatments. Fludarabine phosphate has been shown to induce a cytotoxic effect against tumor cells by binding to ATP-binding cassette transporter proteins on the cell membrane and inhibiting intracellular targets such as DNA, RNA, and protein synthesis. Fludarabine phosphate has also been shown to inhibit the growth of tumor cells through synergistic interactions with other anticancer drugs such as hydroxyurea or busulfan, which may be due to its ability to inhibit enzyme activities such as erythrocyte alkaline phosphatase.

Fórmula: C₁₀H₁₃FN₅O₇P

Pureza: Min. 98 Area-%

Cor e Forma: Powder

Peso molecular: 365.21 g/mol

Ref: 3D-NF01485