CAS 76429-85-1

10-Desacetilcefalomannina

Descrição:

10-Desacetilcefalomannina é um alcaloide natural derivado da espécie de planta *Cephalotaxus*, comumente conhecida como teixo ameixa. É caracterizado por sua complexa estrutura molecular, que inclui um núcleo tetracíclico típico dos derivados de cephalotaxina. Este composto é notável por suas potenciais propriedades farmacológicas, particularmente no campo da oncologia, pois exibe atividade citotóxica contra várias linhagens celulares cancerosas. A substância é frequentemente estudada por seu papel no desenvolvimento de agentes anticancerígenos, pois pode inibir a proliferação celular e induzir apoptose em células malignas. Além disso, 10-Desacetilcefalomannina tem sido investigado por seus efeitos no sistema imunológico e seu potencial uso no tratamento de outras doenças. Sua solubilidade e estabilidade em diferentes solventes podem variar, influenciando sua biodisponibilidade e eficácia terapêutica. Assim como muitos alcaloides, perfis de segurança e toxicidade são considerações essenciais em sua aplicação, exigindo pesquisa minuciosa e avaliação clínica antes do uso terapêutico.

Fórmula: C₄₃H₅₁NO₁₃

InChI: InChI=1S/C43H51NO13/c1-8-22(2)37(50)44-31(25-15-11-9-12-16-25)33(48)39(52)55-27-20-43(53)36(56-38(51)26-17-13-10-14-18-26)34-41(7,35(49)32(47)30(23(27)3)40(43,5)6)28(46)19-29-42(34,21-54-29)57-24(4)45/h8-18,27-29,31-34,36,46-48,53H,19-21H2,1-7H3,(H,44,50)/b22-8+/t27-,28-,29+,31-,32+,33+,34-,36-,41+,42-,43+/m0/s1

Chave InChI: InChIKey=ADDGUHVEJPNWQZ-GJKIWTKTSA-N

SMILES: O(C(C)=O)[C@]12[C@]3([C@H](OC(=O)C4=CC=CC=C4)[C@@]5(O)C(C)(C)C([C@@H](O)C(=O)[C@]3(C)[C@@H](O)C[C@]1(OC2)[H])=C(C)[C@@H](OC([C@@H]([C@@H](NC(/C(=C/C)/C)=O)C6=CC=CC=C6)O)=O)C5)[H]

Sinónimos:

• 10-Deacetylcephalomannine
• 10-Deacetyltaxol B
• 10β-Deacetylcephalomanine
• 7,11-Methano-1H-cyclodeca[3,4]benz[1,2-b]oxete, benzenepropanoic acid deriv.
• Benzenepropanoic acid, α-hydroxy-β-[(2-methyl-1-oxo-2-butenyl)amino]-, 12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, [2aR-[2aα,4β,4aβ,6β,9α[αR*,βS*(E)],11α,12α,12aα,12bα]]-
• Benzenepropanoic acid, α-hydroxy-β-[[(2E)-2-methyl-1-oxo-2-buten-1-yl]amino]-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, (αR,βS)-
• Benzenepropanoic acid, α-hydroxy-β-[[(2E)-2-methyl-1-oxo-2-butenyl]amino]-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, (αR,βS)-
• benzenepropanoic acid, alpha-hydroxy-beta-[[(2E)-2-methyl-1-oxo-2-buten-1-yl]amino]-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, (alphaR,betaS)-

10-Deacetylcephalomannine

CAS: 76429-85-1

10-Deacetylcephalomannin exhibits activity against PS leukemia in vivo; however, its instability leads to an equilibrium mixture with its cytotoxic C-7 epimer. Additionally, 10-Deacetylcephalomannine demonstrates growth inhibitory effects on human cancer cell lines, including cervical HeLa adenocarcinoma.

Fórmula: C₄₃H₅₁NO₁₃

Cor e Forma: Solid

Peso molecular: 789.9

Ref: TM-TN7414

10-Deacetyl Cephalomannine

CAS: 76429-85-1

Fórmula: C₄₃H₅₁NO₃

Peso molecular: 789.88

Ref: 4Z-C-11905

10-Deacetyl Cephalomannine(>85%)

CAS: 76429-85-1

Applications 10-Deacetyl Cephalomannine is a derivative of Cephalomannine (C258500).
References Liu, J., et al.: J. Pharm. Biomed. Anal., 15, 1729 (1997), Montero, A., et al.: Lancet Oncol., 6, 229 (2005), Ojima, I., et al.: J. Nat. Prod. 72, 554 (2009),

Fórmula: C₄₃H₅₁NO₁₃

Cor e Forma: Neat

Peso molecular: 789.86

Ref: TR-D198650

10-Deacetyl cephalomannine

CAS: 76429-85-1

10-Deacetyl cephalomannine is a taxane derivative that has been isolated from the needles of Taxus cuspidata. This compound is metabolized by human liver enzymes, such as cytochrome P450, to 10-deacetyltaxol (10-DT). 10-DT has shown antitumor activity in vitro and in vivo against human cancer cell lines. It also inhibits the growth of Mycobacterium tuberculosis in culture. The mechanism of action for this compound is not known, but it may inhibit protein synthesis or cell division. 10-DT inhibits the growth of cancer cells by binding to tubulin and inhibiting microtubule polymerization.

Fórmula: C₄₃H₅₁NO₁₃

Pureza: Min. 95%

Peso molecular: 789.86 g/mol

Ref: 3D-FD20817

N-Tigloyl Docetaxel

CAS: 76429-85-1

Fórmula: C₄₃H₅₁NO₁₃

Peso molecular: 789.9

Ref: ST-EA-CP-D32046

10-Deacetyl Cephalomannine

CAS: 76429-85-1

Fórmula: C₄₃H₅₁NO₁₃

Peso molecular: 789.87

Ref: ST-EA-CP-C548001