CAS 7665-99-8

cGMP

Descrição:

A substância química referida como cGMP, ou monofosfato de guanosina cíclico, é um nucleotídeo que desempenha um papel crucial como mensageiro secundário em vários processos biológicos. Está envolvido em vias de sinalização que regulam numerosas funções fisiológicas, incluindo vasodilatação, neurotransmissão e crescimento celular. cGMP é sintetizado a partir de trifosfato de guanosina (GTP) pela enzima guanilato ciclase e é degradado por fosfodiesterases. Estruturalmente, cGMP apresenta um grupo fosfato cíclico, que o distingue de seu homólogo linear, GMP. Esta estrutura cíclica permite que cGMP transmita sinais de forma eficaz dentro das células. A substância é solúvel em água e exibe estabilidade sob condições fisiológicas, embora possa ser sensível à hidrólise em certos ambientes. O papel de cGMP no sistema cardiovascular, particularmente na relaxação do músculo liso e na regulação da pressão arterial, destaca sua importância em farmacologia e aplicações terapêuticas. Seu número CAS, 7665-99-8, é frequentemente usado para identificação em bancos de dados químicos e contextos regulatórios.

Fórmula: C₁₀H₁₂N₅O₇P

InChI: InChI=1S/C10H12N5O7P/c11-10-13-7-4(8(17)14-10)12-2-15(7)9-5(16)6-3(21-9)1-20-23(18,19)22-6/h2-3,5-6,9,16H,1H2,(H,18,19)(H3,11,13,14,17)/t3-,5-,6-,9-/m1/s1

Chave InChI: InChIKey=ZOOGRGPOEVQQDX-UUOKFMHZSA-N

SMILES: O=C1C2=C(N(C=N2)[C@H]3[C@H](O)[C@]4([C@](O3)(COP(=O)(O)O4)[H])[H])NC(N)=N1

Sinónimos:

• 3',5'-(Hidrogenofosfato) Ciclico De Guanosina
• 3',5'-(Hydrogenophosphate) Cyclique De Guanosine
• 3',5'-Cyclic GMP
• 3',5'-Gmp
• 3′,5′-Cyclic GMP
• 3′,5′-Gmp
• 4H-Furo[3,2-d]-1,3,2-dioxaphosphorin, guanosine deriv.
• Cyclic 3',5'-GMP
• Cyclic 3',5'-guanylic acid
• Cyclic 3′,5′-GMP
• Cyclic 3′,5′-guanylic acid
• Cyclic GMP
• Cyclic guanosine 3',5'-monophosphate
• Cyclic guanosine 3′,5′-monophosphate
• Cyclic guanosine monophosphate
• Guanosin-cyclisch-3',5'-(hydrogenphosphat)
• Guanosine 3',5'-monophosphate
• Guanosine 3',5'-phosphate
• Guanosine 3',5'-phosphate (cyclic)
• Guanosine 3′,5′-monophosphate
• Guanosine 3′,5′-phosphate
• Guanosine 3′,5′-phosphate (cyclic)
• Guanosine cyclic 3',5'-monophosphate
• Guanosine cyclic 3',5'-phosphate
• Guanosine cyclic 3′,5′-monophosphate
• Guanosine cyclic 3′,5′-phosphate
• Guanosine, cyclic 3′,5′-(hydrogen phosphate)

Guanosine 3',5'-monophosphate

CAS: 7665-99-8

Fórmula: C₁₀H₁₂N₅O₇P

Pureza: 95%

Cor e Forma: Solid

Peso molecular: 345.2053

Ref: IN-DA005W1X

Cyclic GMP

CAS: 7665-99-8

Cyclic GMP is an endogenous second messenger that initiates interferon production in response to cytoplasmic DNA. It activates the stimulator of interferon genes (STING), triggering a signaling cascade that results in the production of type I interferons and other immune mediators. The conjugate of cyclic GMP and AMP, known as Cyclic-GMP-AMP, can induce the phosphorylation and nuclear translocation of IRF3, thereby enhancing antiviral immune responses. Additionally, Cyclic GMP may activate PDE to degrade cAMP, inhibit the myocardial calcium current ICa, and regulate cardiac contractility. The derivative 8-Br-cGMP exhibits antiplatelet activity, and Cyclic GMP is used in research related to antiviral immunity and cardiovascular diseases.

Fórmula: C₁₀H₁₂N₅O₇P

Cor e Forma: Solid

Peso molecular: 345.205

Ref: TM-TN9056

2-Amino-9-((4Ar,6R,7R,7As)-2,7-Dihydroxy-2-Oxidotetrahydro-4H-Furo[3,2-D][1,3,2]Dioxaphosphinin-6-Yl)-1,9-Dihydro-6H-Purin-6-One

CAS: 7665-99-8

2-Amino-9-((4Ar,6R,7R,7As)-2,7-Dihydroxy-2-Oxidotetrahydro-4H-Furo[3,2-D][1,3,2]Dioxaphosphinin-6-Yl)-1,9-Dihydro-6H-Purin-6-One

Pureza: 99%

Peso molecular: 345.21g/mol

Ref: 54-OR1030896

Guanosine 3'',5''-cyclic monophosphate

CAS: 7665-99-8

Fórmula: C₁₀H₁₂N₅O₇P

Pureza: (HPLC) ≥ 98.0%

Cor e Forma: White powder

Peso molecular: 345.21

Ref: 7W-GN9625

cGMP

CAS: 7665-99-8

Fórmula: C₁₀H₁₂N₅O₇P

Pureza: >92.0%(qNMR)

Cor e Forma: White to Light yellow powder to crystal

Peso molecular: 345.21

Ref: 3B-G0666

Guanosine 3,5-Cyclic Monophosphate

CAS: 7665-99-8

Fórmula: C₁₀H₁₂N₅O₇P

Peso molecular: 345.21

Ref: 4Z-G-2444

Guanosine 3',5'-cyclic monophosphate

CAS: 7665-99-8

Guanosine 3',5'-cyclic monophosphate (cGMP) is a nucleotide that functions as a second messenger in the cell. It is involved in many cellular processes, including mitochondrial functions and energy metabolism. cGMP is synthesized from guanosine triphosphate (GTP) by the enzyme guanine nucleotide-binding protein, which hydrolyzes the phosphate group from GTP to form cGMP. cGMP has been shown to be involved in neuronal death, axonal growth, and glucose uptake in cells. Optimum concentrations of cGMP have been found to be between 1-10 μM. It has also been shown to be an important mediator of cyclic axonal growth and bowel disease. Guanosine 3',5'-cyclic monophosphate can also act as a polymerase chain reaction primer for DNA amplification in vitro.

Fórmula: C₁₀H₁₂N₅O₇P

Pureza: Min. 98 Area-%

Cor e Forma: White Powder

Peso molecular: 345.21 g/mol

Ref: 3D-NG03522

Guanosine 3′,5′-monophosphate

CAS: 7665-99-8

Fórmula: C₁₀H₁₂N₅O₇P

Pureza: 98%

Cor e Forma: Liquid

Peso molecular: 345.208

Ref: 10-F329441

Guanosine 3',5'-Cyclic Monophosphate

Produto Controlado

CAS: 7665-99-8

Stability Hygroscopic
Applications Guanosine 3',5'-cyclic monophosphate is an intracellular second messenger which are involved in the transduction of a diverse array of stimuli, mediating metabolic and growth regulation.
References Aladelokun, O., et al.: Curr. Drug Metab., 18, 1132-1135 (2017)

Fórmula: C₁₀H₁₂N₅O₇P

Cor e Forma: Neat

Peso molecular: 345.205

Ref: TR-G838710