CAS 76712-82-8

des-gly10,(D-his(bzl)6)-lh-rh*etilamida

Descrição:

des-gly10,(D-his(bzl)6)-lh-rh*etilamida, com o número CAS 76712-82-8, é um análogo de peptídeo sintético derivado do hormônio que ocorre naturalmente, o hormônio liberador de luteinizante (LHRH). Este composto é caracterizado por suas modificações estruturais, que incluem a exclusão do resíduo de glicina na posição 10 e a incorporação de um resíduo de D-histidina com um grupo benzila na posição 6. Essas modificações aumentam sua estabilidade e bioatividade em comparação com a LHRH nativa. O composto geralmente exibe alta afinidade pelos receptores de LHRH, tornando-o de interesse em pesquisas relacionadas à biologia reprodutiva e potenciais aplicações terapêuticas em distúrbios relacionados a hormônios. Sua estrutura única permite uma ação prolongada em sistemas biológicos, o que pode ser benéfico em ambientes clínicos. Como peptídeo, é geralmente solúvel em soluções aquosas e pode exigir condições específicas para armazenamento e manuseio para manter sua integridade. No geral, des-gly10,(D-his(bzl)6)-lh-rh*etilamida representa um avanço significativo no design de peptídeos para terapias hormonais direcionadas.

Fórmula: C₆₆H₈₆N₁₈O₁₂

InChI: InChI=1/C66H86N18O12.C2H4O2/c1-4-70-64(95)55-17-11-25-84(55)65(96)48(16-10-24-71-66(67)68)76-58(89)49(26-38(2)3)77-62(93)53(30-43-34-83(37-74-43)33-40-12-6-5-7-13-40)81-59(90)50(27-39-18-20-44(86)21-19-39)78-63(94)54(35-85)82-60(91)51(28-41-31-72-46-15-9-8-14-45(41)46)79-61(92)52(29-42-32-69-36-73-42)80-57(88)47-22-23-56(87)75-47;1-2(3)4/h5-9,12-15,18-21,31-32,34,36-38,47-55,72,85-86H,4,10-11,16-17,22-30,33,35H2,1-3H3,(H,69,73)(H,70,95)(H,75,87)(H,76,89)(H,77,93)(H,78,94)(H,79,92)(H,80,88)(H,81,90)(H,82,91)(H4,67,68,71);1H3,(H,3,4)/t47-,48-,49-,50-,51-,52-,53+,54-,55-;/m0./s1

Sinónimos:

• Histrelin
• 5-oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-1-benzyl-D-histidyl-L-leucyl-L-arginyl-N-ethyl-L-prolinamide
• 5-oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-1-benzyl-D-histidyl-L-leucyl-L-arginyl-N-ethyl-L-prolinamide acetate (1:1)
• ^-benzyl-D-histidyl-L-leucyl-L-arginyl-N-ethyl-L-pmlinamide
• 6-(1-(phenylmethyl)-d-histidine)-9-luteinizinghormonereleasingfactor(pig
• (n-ethyl-l-prolinamide)-10-deglycinamide-
• (DES-GLY10,HIS(BZL)6,PRO-NHET9)-GONADOTROPIN-RELEASING HORMONE
• Supprelin
• Histreline Acetate
• histrelin acetate
• 1-9-LUTEINIZING HORMONE-RELEASING FACTOR (SWINE), 6-[1-(PHENYLMETHYL)-D-HISTIDINE]-9-(N-ETHYL-L-PROLINAMIDE)-
• 5-Oxo-L-Pro-L-His-L-Trp-L-Ser-L-Tyr-1-benzyl-D-His-L-Leu-L-Arg-L-Pro-N-ethyl-NH2
• RWJ-17070
• DES-GLY10,[D-HIS(BZL)6]-LH-RH ETHYLAMIDE
• [DES-GLY10, D-HIS(BZL)6, PRO-NHET9]-LUTEINIZING HORMONE-RELEASING HORMONE (HUMAN)
• ((imbl)-d-his(sub6),pro(sub9)-net)lhrh
• (DES-GLY10,D-HIS(BZL)6,PRO-NHET9)-LUTEINIZING HORMONE-RELEASING HORMONE
• PYR-HIS-TRP-SER-TYR-D-HIS(BZL)-LEU-ARG-PRO-NHET
• orf17070
• (HIS(BZL)6)-HISTRELIN
• (DES-GLY10,D-HIS(BZL)6,PRO-NHET9)-LHRH
• Pyr-His-Trp-Ser-Tyr-D-His(Bzl)-Leu-Arg-Pro-NHEt acetate salt
• (DES-GLY10,HIS(BZL)6,PRO-NHET9)-LUTEINIZING HORMONE-RELEASING FACTOR
• 5-oxo-L-pmlyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-N^
• [DES-GLY10, D-HIS(BZL)6, PRO-NHET9]-LH-RH (HUMAN)
• (DES-GLY10,D-HIS(BZL)6,PRO-NHET9)-LUTEINIZING HORMONE-RELEASING FACTOR
• (DES-GLY10,HIS(BZL)6,PRO-NHET9)-LHRH
• PYR-HIS-TRP-SER-TYR-HIS(BZL)-LEU-ARG-PRO-NHET
• (DES-GLY10,HIS(BZL)6,PRO-NHET9)-LUTEINIZING HORMONE-RELEASING HORMONE
• PGLU-HIS-TRP-SER-TYR-D-HIS[BZL]-LEU-ARG-PRO-NHET

Histrelin

CAS: 76712-82-8

Fórmula: C₆₆H₈₆N₁₈O₁₂

Peso molecular: 1323.50

Ref: 7W-GP6870

Histrelin

CAS: 76712-82-8

Fórmula: C₆₆H₈₆N₁₈O₁₂

Peso molecular: 1323.53

Ref: 4Z-PH-047001

Histrelin Acetate

CAS: 76712-82-8

Fórmula: C₆₆H₈₆N₁₈O₁₂

Pureza: 95%~99%

Cor e Forma: White to Off-white Powder

Peso molecular: 1323.5

Ref: BP-BPPG040

Histrelin Acetic Acid Salt

CAS: 76712-82-8

Applications Histrelin is a gonadotropin releasing hormone analog used with the potential to improve height prospects.
References Brauner, R. et al.: Nat. Rev. Endocrinol., 11, 386 (2015);

Fórmula: C₆₆H₈₆N₁₈O₁₂•xCH₃COOH

Cor e Forma: Neat

Peso molecular: 1323.506005

Ref: TR-H456310

Histrelin Acetate

CAS: 76712-82-8

Histrelin acetate is a synthetic analog of the natural hormone histrelin. It has been used clinically to treat prostate cancer, androgenetic alopecia, and other conditions. Histrelin acetate binds to receptors in the hypothalamus and pituitary gland that are responsible for regulating the production of sex hormones. This drug is administered by injection into the pubic area or under the skin as an implant. Histrelin acetate's effectiveness is related to its suppression of gonadotropins, which results in decreased testosterone levels. Histrelin acetate also decreases testosterone production by inhibiting gonadotropin-releasing hormone from stimulating the anterior pituitary gland to produce luteinizing hormone (LH) and follicle-stimulating hormone (FSH). The long-term efficacy of this drug has been demonstrated in clinical studies lasting up to two years with no significant adverse effects on bone mineral density or sexual function.

Pureza: Min. 95%

Ref: 3D-FH138112