CAS 767340-03-4

(2Z)-3-Amino-1-[5,6-diidro-3-(trifluorometil)-1,2,4-triazolo[4,3-a]pirazin-7(8H)-il]-4-(2,4,5-trifluorofenil)-2-buten-1-ona

Descrição:

(2Z)-3-Amino-1-[5,6-diidro-3-(trifluorometil)-1,2,4-triazolo[4,3-a]pirazin-7(8H)-il]-4-(2,4,5-trifluorofenil)-2-buten-1-ona é um composto orgânico complexo caracterizado por suas características estruturais únicas, incluindo um núcleo de triazolo-pirazina e múltiplos substituintes trifluorometílico e trifluorofenila. Este composto exibe atividade biológica significativa, frequentemente investigada por seu potencial como agente farmacêutico. A presença do grupo amino sugere que pode participar de ligações de hidrogênio, influenciando sua solubilidade e reatividade. Os grupos trifluorometílicos aumentam a lipofilicidade e podem contribuir para as propriedades farmacocinéticas do composto. Além disso, o sistema conjugado formado pela parte de butenona pode fornecer reatividade em várias transformações químicas. Sua estrutura molecular indica interações potenciais com alvos biológicos, tornando-o um assunto de interesse em química medicinal. No geral, este composto exemplifica a intrincada relação entre a estrutura molecular e a atividade biológica, destacando a importância dos compostos fluorados no design de medicamentos.

Fórmula: C₁₆H₁₃F₆N₅O

InChI: InChI=1/C16H13F6N5O/c17-10-6-12(19)11(18)4-8(10)3-9(23)5-14(28)26-1-2-27-13(7-26)24-25-15(27)16(20,21)22/h4-6H,1-3,7,23H2/b9-5-

Chave InChI: InChIKey=RLSFDUAUKXKPCZ-UITAMQMPSA-N

SMILES: C(F)(F)(F)C=1N2C(CN(C(/C=C(/CC3=C(F)C=C(F)C(F)=C3)\N)=O)CC2)=NN1

Sinónimos:

• (2Z)-3-Amino-1-[5,6-dihydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)-2-buten-1-one
• (2Z)-4-Oxo-4-[3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)but-2-en-2-amine
• (Z)-3-amino-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)but-2-en-1-one
• 1,2,4-Triazolo[4,3-a]pyrazine, 7-[(2Z)-3-amino-1-oxo-4-(2,4,5-trifluorophenyl)-2-butenyl]-5,6,7,8-tetrahydro-3-(trifluoromethyl)-
• 2-Buten-1-one, 3-amino-1-[5,6-dihydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)-, (2Z)-
• (2Z)-4-Oxo-4-[3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazine-7(8H)-yl]-1-(2,4,5-trifluorophenyl)but-2-en-2-amine
• （2Z）-2-amine-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro][1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)but-2-en (2-4)
• (2Z)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]

Sitagliptin Enamine ((Z)-3-amino-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)but-2-en-1-one)

CAS: 767340-03-4

Compounds containing a pyrimidine ring, whether or not hydrogenated, or piperazine ring in the structure, nesoi

Fórmula: C₁₆H₁₃F₆N₅O

Cor e Forma: Off-White Solid

Peso molecular: 405.10243

Ref: 45-1A02650

(2Z)-4-Oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazine-7(8H)-yl]-1-(2,4,5-trifluorophenyl)but-2-en-2-amine

CAS: 767340-03-4

Fórmula: C₁₆H₁₃F₆N₅O

Pureza: 98%

Cor e Forma: Solid

Peso molecular: 405.2977

Ref: IN-DA0036IO

(2Z)-4-Oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazine-7(8H)-yl]-1-(2,4,5-trifluorophenyl)but-2-en-2-amine

CAS: 767340-03-4

(2Z)-4-Oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazine-7(8H)-yl]-1-(2,4,5-trifluorophenyl)but-2-en-2-amine

Pureza: 95%

Peso molecular: 405.3g/mol

Ref: 54-PC1004071

Sitagliptin Impurity 34

CAS: 767340-03-4

Fórmula: C₁₆H₁₃F₆N₅O

Cor e Forma: White To Off-White Solid

Peso molecular: 405.30

Ref: 4Z-S-2011

(2Z)-4-Oxo-4-[3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)but-2-en-2-amine

CAS: 767340-03-4

Cor e Forma: Neat

Ref: 86-MM3378.20

(2Z)-4-Oxo-4-[3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifl

Produto Controlado

CAS: 767340-03-4

Applications Sitagliptin intermediate. A dipeptidyl peptidase-4 inhibitor and an anti-hypertensive agent for the treatment of diabetes and hypertension.
References Kim, D., et al.: J. Med. Chem., 48, 141 (2005), Ahren, B., et al.: Eur. J. Pharmacol., 521 164 (2005), Bergman, A., et al: Clin. Ther., 28, 55 (2006)

Fórmula: C₁₆H₁₃F₆N₅O

Cor e Forma: White

Peso molecular: 405.30

Ref: TR-O865000

(2Z)-4-Oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazine-7(8H)-yl]-1-(2,4,5-trifluorophenyl)but-2-en-2-amine

CAS: 767340-03-4

(2Z)-4-Oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazine-7(8H)-yl]-1-(2,4,5-trifluorophenyl)but-2-en-2-amine is a drug that has been studied in hemodialysis patients and found to reduce the mutation rate. It is also thought to be beneficial for hematocrit levels and x-ray parameters. The mechanism of action of this drug is not yet fully understood. Low doses are thought to have a protective effect on germ cells, whereas high doses are thought to have an adverse effect on them. Iron supplementation may help with the adverse effects of high doses.

Fórmula: C₁₆H₁₃F₆N₅O

Pureza: Min. 95%

Cor e Forma: White Off-White Powder

Peso molecular: 405.3 g/mol

Ref: 3D-FO155533

Sitagliptin Enamine Impurity

CAS: 767340-03-4

Fórmula: C₁₆H₁₃F₆N₅O

Peso molecular: 405.30

Ref: ST-EA-CP-S3016

(2Z)-4-Oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazine-7(8H)-yl]-1-(2,4,5-trifluorophenyl)but-2-en-2-amine

CAS: 767340-03-4

(2Z)-4-Oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazine-7(8H)-yl]-1-(2,4,5-trifluorophenyl)but-2-en-2-amine is a useful organic compound for research related to life sciences. The catalog number is T66986 and the CAS number is 767340-03-4.

Fórmula: C₁₆H₁₃F₆N₅O

Cor e Forma: Solid

Peso molecular: 405.304

Ref: TM-T66986