CAS 76801-85-9

9-Deoxo-9a-aza-9a-homoeritromicina A

Descrição:

9-Deoxo-9a-aza-9a-homoeritromicina A, com o número CAS 76801-85-9, é um derivado semissintético da eritromicina, um antibiótico macrolídeo. Este composto é caracterizado pela presença de um átomo de nitrogênio na posição 9a, o que altera suas propriedades farmacológicas em comparação com seu composto original. Ele exibe atividade antibacteriana principalmente contra bactérias Gram-positivas e algumas cepas Gram-negativas, tornando-o útil no tratamento de várias infecções bacterianas. As modificações estruturais aumentam sua estabilidade e biodisponibilidade, permitindo uma eficácia melhorada. Como outros macrolídeos, funciona inibindo a síntese de proteínas bacterianas através da ligação à subunidade ribossômica 50S. Além disso, pode apresentar um espectro de atividade mais amplo e menor suscetibilidade a certos mecanismos de resistência bacteriana. A solubilidade, estabilidade e propriedades farmacocinéticas do composto são influenciadas por sua estrutura única, o que pode afetar suas aplicações terapêuticas e esquemas de dosagem. No geral, 9-Deoxo-9a-aza-9a-homoeritromicina A representa um desenvolvimento importante no campo da pesquisa e tratamento de antibióticos.

Fórmula: C₃₇H₇₀N₂O₁₂

InChI: InChI=1S/C37H70N2O12/c1-14-26-37(10,45)30(41)23(6)38-18-19(2)16-35(8,44)32(51-34-28(40)25(39(11)12)15-20(3)47-34)21(4)29(22(5)33(43)49-26)50-27-17-36(9,46-13)31(42)24(7)48-27/h19-32,34,38,40-42,44-45H,14-18H2,1-13H3/t19-,20-,21+,22-,23-,24+,25+,26-,27+,28-,29+,30-,31+,32-,34+,35-,36-,37-/m1/s1

Chave InChI: InChIKey=HRKNNHYKWGYTEN-HOQMJRDDSA-N

SMILES: O([C@H]1[C@H](C)[C@@H](O[C@H]2[C@H](O)[C@@H](N(C)C)C[C@@H](C)O2)[C@](C)(O)C[C@@H](C)CN[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@@H]1C)[C@H]3C[C@](OC)(C)[C@@H](O)[C@H](C)O3

Sinónimos:

• (2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-13-[(2,6-Dideoxy-3-C-methyl-3-O-methyl-α-<span class="text-smallcaps">L</smallcap>-ribo-hexopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-<smallcap>D</span>-xylo-hexopyranosyl]oxy]-1-oxa-6-azacyclopentadecan-15-one
• 1-Oxa-6-azacyclopentadecan-15-one, 13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-α-<span class="text-smallcaps">L</smallcap>-ribo-hexopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-<smallcap>D</span>-xylo-hexopyranosyl]oxy]-, (2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-
• 1-Oxa-6-azacyclopentadecan-15-one, 13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-α-<span class="text-smallcaps">L</smallcap>-ribo-hexopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-<smallcap>D</span>-xylo-hexopyranosyl]oxy]-, [2R-(2R*,3S*,4R*,5R*,8R*,10R*,11R*,12S*,13S*,14R*)]-
• 2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-15-oxo-11-{[3,4,6-trideoxy-3-(dimethylamino)hexopyranosyl]oxy}-1-oxa-6-azacyclopentadecan-13-yl 2,6-dideoxy-3-C-methyl-3-O-methylhexopyranoside
• 9-Deoxo-9a-aza-9a-homoerythromycin A
• Aza-erythromycin
• Azaerythromycin A
• Azahomoerythromycin
• Desmethyl Azithromycin
• 1-Oxa-6-azacyclopentadecan-15-one, 13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-α-L-ribo-hexopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosyl]oxy]-, [2R-(2R*,3S*,4R*,5R*,8R*,10R*,11R*,12S*,13S*,14R*)]-
• 1-Oxa-6-azacyclopentadecan-15-one, 13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-α-L-ribo-hexopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosyl]oxy]-, (2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-
• (2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-13-[(2,6-Dideoxy-3-C-methyl-3-O-methyl-α-L-ribo-hexopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosyl]oxy]-1-oxa-6-azacyclopentadecan-15-one

Azaerythromycin A (9-Deoxo-9a-aza-9a-homoerythromycin A)

CAS: 76801-85-9

Nucleic acids and their salts, whether or not chemically defined; other heterocyclic compounds, nesoi

Fórmula: C₃₇H₇₀N₂O₁₂

Cor e Forma: White Powder

Peso molecular: 734.49288

Ref: 45-1045600

9-Deoxo-9a-aza-9a-homo Erythromycin A Desmethyl Azithromycin

CAS: 76801-85-9

Fórmula: C₃₇H₇₀N₂O₁₂

Pureza: 95%

Cor e Forma: Solid

Peso molecular: 734.9579

Ref: IN-DA005I8G

Azathramycin

CAS: 76801-85-9

Azathramycin

Pureza: 97%

Peso molecular: 734.96g/mol

Ref: 54-OR1028380

Azathramycin

CAS: 76801-85-9

Azathramycin

Pureza: ≥98%

Peso molecular: 734.96g/mol

Ref: 54-BUP15770

Azithromycin EP Impurity A (Azathramycin, Desmethyl Azithromycin)

CAS: 76801-85-9

Fórmula: C₃₇H₇₀N₂O₁₂

Cor e Forma: White To Off-White Solid

Peso molecular: 734.97

Ref: 4Z-A-2620

6-Demethylazithromycin (Azaerythromycin A)

Produto Controlado

CAS: 76801-85-9

Fórmula: C₃₇H₇₀N₂O₁₂

Cor e Forma: Neat

Peso molecular: 734.96

Ref: 86-MM1075.01

Azathramycin

CAS: 76801-85-9

Azathramycin (Desmethyl Azithromycin) is an antibiotic derived from erythromycin, binding to the 50S subunit of the bacterial ribosome, and thus inhibits

Fórmula: C₃₇H₇₀N₂O₁₂

Pureza: 99.71%

Cor e Forma: White To Grayish Solid Powder

Peso molecular: 734.96

Ref: TM-T3265

Azithromycin EP Impurity A

CAS: 76801-85-9

Fórmula: C₃₇H₇₀N₂O₁₂

Peso molecular: 734.96

Ref: ST-EA-CP-A37001

9-Deoxo-9a-aza-9a-homo Erythromycin A (Desmethyl Azithromycin)

Produto Controlado

CAS: 76801-85-9

Impurity Azithromycin EP Impurity A
Applications 9-Deoxo-9a-aza-9a-homo Erythromycin A (Azithromycin EP Impurity A) is a novel intermediate of Azithromycin that acts as antibiotic.
References Krajacic, M.B., et al.: J. Antibiot., 58, 380 (2005),

Fórmula: C₃₇H₇₀N₂O₁₂

Cor e Forma: Neat

Peso molecular: 734.96

Ref: TR-D231500

9-Deoxo-9a-aza-9a-homo erythromycin A

CAS: 76801-85-9

9-Deoxo-9a-aza-9a-homo erythromycin A is a semi-synthetic macrolide antibiotic, which is derived from the naturally occurring antibiotic erythromycin. This compound is structurally modified to enhance its pharmacokinetic properties and antibacterial spectrum. By altering the erythromycin molecule, 9-Deoxo-9a-aza-9a-homo erythromycin A introduces a nitrogen atom into the lactone ring, thereby modifying its interaction with bacterial ribosomes.

Fórmula: C₃₇H₇₀N₂O₁₂

Pureza: (%) Min. 90%

Cor e Forma: White Powder

Peso molecular: 734.96 g/mol

Ref: 3D-AD21039

Azaerythromycin (AZAE)

CAS: 76801-85-9

Fórmula: C₃₇H₃₀N₂O₁₂

Cor e Forma: White, Crystalline powder

Peso molecular: 734.96

Ref: SR-59070

Azathramycin

CAS: 76801-85-9

Pureza: 98%

Peso molecular: 734.969

Ref: 10-F987657

Azithromycin impurity A

CAS: 76801-85-9

Azithromycin impurity A is an impurity of azithromycin that has been shown to have antibacterial activity in test organisms. It is a crystalline compound, which can be isolated from the antibiotic erythromycin by recrystallization. Impurity A has a molecular weight of 543.3 and can be identified by its X-ray powder diffraction pattern. The chemical formula for impurity A is C12H15N2O4S2 with an elemental composition of C, H, N, O, and S.

Fórmula: C₃₇H₇₀N₂O₁₂

Pureza: Min. 95 Area-%

Cor e Forma: Powder

Peso molecular: 735.00 g/mol

Ref: 3D-FA63629