CAS 7770-78-7

(-)-Arctigenina

Descrição:

(-)-Arctigenina é um composto lignano que ocorre naturalmente, encontrado principalmente em várias plantas, incluindo a raiz de bardana (Arctium lappa). É caracterizado por sua estrutura fenólica, que contribui para suas atividades biológicas. O composto exibe uma gama de propriedades farmacológicas, incluindo efeitos anti-inflamatórios, antioxidantes e potenciais efeitos anticancerígenos. (-)-Arctigenina tem sido estudado por sua capacidade de modular várias vias de sinalização, o que pode influenciar a proliferação celular e a apoptose. Além disso, mostrou-se promissor na proteção contra doenças neurodegenerativas devido às suas propriedades neuroprotetoras. A substância é tipicamente solúvel em solventes orgânicos e tem solubilidade limitada em água, o que pode afetar sua biodisponibilidade. Sua fórmula molecular reflete uma disposição complexa de átomos de carbono, hidrogênio e oxigênio, contribuindo para suas diversas atividades biológicas. No geral, (-)-Arctigenina é de grande interesse na química medicinal e farmacologia por suas potenciais aplicações terapêuticas.

Fórmula: C₂₁H₂₄O₆

InChI: InChI=1/C21H24O6/c1-24-18-7-5-13(11-20(18)26-3)8-15-12-27-21(23)16(15)9-14-4-6-17(22)19(10-14)25-2/h4-7,10-11,15-16,22H,8-9,12H2,1-3H3

Chave InChI: InChIKey=NQWVSMVXKMHKTF-JKSUJKDBSA-N

SMILES: C([C@@H]1[C@@H](CC2=CC(OC)=C(OC)C=C2)COC1=O)C3=CC(OC)=C(O)C=C3

Sinónimos:

• (3R,4R)-4-(3,4-dimethoxybenzyl)-3-(4-hydroxy-3-methoxybenzyl)dihydrofuran-2(3H)-one
• (3R,4R)-4-[(3,4-Dimethoxyphenyl)methyl]dihydro-3-[(4-hydroxy-3-methoxyphenyl)methyl]-2(3H)-furanone
• 2(3H)-Furanone, 4-((3,4-dimethoxyphenyl)methyl)dihydro-3-((4-hydroxy-3-methoxyphenyl)methyl)-, (3R,4R)-
• 2(3H)-Furanone, 4-((3,4-dimethoxyphenyl)methyl)dihydro-3-((4-hydroxy-3-methoxyphenyl)methyl)-, (3R-trans)-
• 4-(3,4-dimethoxybenzyl)-3-(4-hydroxy-3-methoxybenzyl)dihydrofuran-2(3H)-one
• Arctidine
• (-)-Arctigenin
• (-)-Arctigenin
• Arctigenin
• dihydro-3-[(4-hydroxy-3-methoxyphenyl)methyl]-,(3R,4R)-
• (3R,4R)-3-(3-Methoxy-4-hydroxybenzyl)-4-(3,4-dimethoxybenzyl)tetrahydrofuran-2-one
• 2(3H)-FURANONE,4-[(3,4-DIMETHOXYPHENYL)METHYL]DIHYDRO-3-[(4-HYDROXY-3-METHOXYPHENYL)METHYL]
• 2(3H)-Furanone,4-[(3,4-dimethoxyphenyl) methyl]
• ARCTIGENIN:2(3H)-FURANONE,4-[(3,4-DIMETHOXYPHENYL)METHYL]DIHYDRO-3-[(4-HYDROXY-3-METHOXYPHENYL)METHYL]-,(3R,4R)
• ARCTIGENIN(P)
• (3R,4R)-4-[(3,4-Dimethoxyphenyl)methyl]-3-[(4-hydroxy-3-methoxyphenyl)methyl]tetrahydrofuran-2-one
• (3R)-3α-(3-Methoxy-4-hydroxybenzyl)-4β-(3,4-dimethoxybenzyl)-4,5-dihydrofuran-2(3H)-one

ARCTIGENIN

CAS: 7770-78-7

Fórmula: C₂₁H₂₄O₆

Pureza: 98%

Cor e Forma: Solid

Peso molecular: 372.4117

Ref: IN-DA005GJC

Arctigenin

CAS: 7770-78-7

Arctigenin

Pureza: ≥95%

Peso molecular: 372.41g/mol

Ref: 54-BUP00018

(-)-Arctigenin

CAS: 7770-78-7

Fórmula: C₂₁H₂₄O₆

Pureza: >95.0%(GC)

Cor e Forma: White to Light yellow powder to crystal

Peso molecular: 372.42

Ref: 3B-A3117

Arctigenin

CAS: 7770-78-7

Arctigenin, naturally occurring in Bardanae fructus, Saussurea medusa, Arctium lappa L., Torreya nucifera and Ipomea cairica, is a phenylpropanoid dibenzylbutyrolactone lignan with antioxidant and anti-inflammatory activities, it can potently inhibit the activity of MKK1 in vitro with the IC(50) value of 1 nM, and inhibit activation of MAP kinases including ERK1/2, p38 kinase and JNK through the inhibition of MKK activities, leading to AP-1 inactivation, which might, at least in part, contribute to the inhibition of TNF-α production, inhibits expression via suppressing JAK-pathway in macrophages.[1,2]

Fórmula: C₂₁H₂₄O₆

Pureza: 95%~99%

Cor e Forma: Powder

Peso molecular: 372.417

Ref: BP-BP0186

Arctigenin

CAS: 7770-78-7

(-)-Arctigenin ((-)-Arctigenin) is found in burdock.

Fórmula: C₂₁H₂₄O₆

Pureza: 98% - 99.51%

Cor e Forma: Solid

Peso molecular: 372.41

Ref: TM-T2957

Arctigenin

CAS: 7770-78-7

Fórmula: C₂₁H₂₄O₆

Peso molecular: 372.42

Ref: 7W-GY3454

Arctigenin

CAS: 7770-78-7

Lactone

Fórmula: C₂₁H₂₄O₆

Pureza: ≥ 98.0 % (HPLC)

Cor e Forma: Powder

Peso molecular: 372.42

Ref: 5G-80354

Arctigenin

Produto Controlado

CAS: 7770-78-7

Applications Arctigenin is a plant ligan associated with anticancer and antioxidant properties.
References Heinonen, S., et al.: J. Agric. Food Chem., 49, 3178-3186 (2001); Cai, Y., et al.: Life Sci., 78, 2877-2888 (2006)

Fórmula: C₂₁H₂₄O₆

Cor e Forma: Neat

Peso molecular: 372.41

Ref: TR-A766580

(-)-Arctigenin

CAS: 7770-78-7

(-)-Arctigenin is a lignan compound, which is naturally derived from certain plant species, primarily found in the seeds of Arctium lappa, commonly known as burdock. The compound exhibits a diverse mode of action, primarily noted for its ability to inhibit the proliferation of cancer cells through apoptosis induction, cell cycle arrest, and modulation of various signaling pathways. Additionally, it exerts antiviral effects by targeting viral replication processes and exhibits anti-inflammatory properties by downregulating pro-inflammatory cytokines.

Fórmula: C₂₁H₂₄O₆

Pureza: Min. 94.0 Area-%

Peso molecular: 372.41 g/mol

Ref: 3D-Q-100825

(-)-Arctigenin

CAS: 7770-78-7

(-)-Arctigenin is a natural lignan, which is an active compound isolated from plants such as Arctium lappa (greater burdock) and other members of the Asteraceae family. It acts via several biochemical pathways, notably by inhibiting cellular proliferation and inducing apoptosis in certain cancer cell lines. Additionally, (-)-Arctigenin can modulate immune responses and possesses anti-inflammatory and antiviral properties by interfering with viral replication processes.

Fórmula: C₂₁H₂₄O₆

Pureza: Min. 95%

Cor e Forma: White Powder

Peso molecular: 372.41 g/mol

Ref: 3D-FA41645