CAS 7772-94-3

2-(Acetilamino)-2-desoxi-β-D-manopiranose

Descrição:

2-(Acetilamino)-2-desoxi-β-D-manopiranose, comumente referido como N-acetilmanosamina, é um amino açúcar que desempenha um papel significativo em vários processos biológicos, particularmente na síntese de glicoproteínas e glicolípidos. Este composto apresenta um grupo acetilamino na posição C-2 do anel de manopiranose, o que contribui para suas propriedades bioquímicas. Normalmente, é um sólido cristalino branco a off-white que é solúvel em água, refletindo sua natureza polar devido aos grupos hidroxila e amino. A presença do grupo acetilamino aumenta sua reatividade e permite que participe de várias vias metabólicas, incluindo aquelas envolvidas na biossíntese do ácido siálico. A N-acetilmanosamina também é importante em processos de sinalização e reconhecimento celular, tornando-se um assunto de interesse na pesquisa relacionada a interações celulares e mecanismos de doenças. Seu número CAS, 7772-94-3, é usado para identificação em bancos de dados químicos e contextos regulatórios. No geral, este composto é significativo tanto na bioquímica quanto em aplicações farmacêuticas.

Fórmula: C₈H₁₅NO₆

InChI: InChI=1S/C8H15NO6/c1-3(11)9-5-7(13)6(12)4(2-10)15-8(5)14/h4-8,10,12-14H,2H2,1H3,(H,9,11)/t4-,5+,6-,7-,8-/m1/s1

Chave InChI: InChIKey=OVRNDRQMDRJTHS-OZRXBMAMSA-N

SMILES: N(C(C)=O)[C@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O

Sinónimos:

• 2-(Acetylamino)-2-Deoxyhexopyranose Hydrate
• 2-(Acetylamino)-2-deoxy-β-<span class="text-smallcaps">D</span>-mannopyranose
• 2-(acetylamino)-2-deoxy-alpha-D-gulopyranose
• Mannopyranose, 2-acetamido-2-deoxy-, β-<span class="text-smallcaps">D</span>-
• N-Acetyl-D-mannosamine monohydrate
• β-<span class="text-smallcaps">D</span>-Mannopyranose, 2-(acetylamino)-2-deoxy-
• 2-(Acetylamino)-2-deoxy-β-D-mannopyranose
• β-D-Mannopyranose, 2-(acetylamino)-2-deoxy-
• Mannopyranose, 2-acetamido-2-deoxy-, β-D-

N-Acetylmannosamine

CAS: 7772-94-3

Fórmula: C₈H₁₅NO₆

Pureza: 95%

Cor e Forma: Solid

Peso molecular: 221.2078

Ref: IN-DA003SOW

N-Acetyl-D-mannosamine

CAS: 7772-94-3

Fórmula: C₈H₁₅NO₆·xH₂O

Pureza: ≥ 98.0%

Cor e Forma: White to off-white powder

Peso molecular: 221.21 (anhydrous)

Ref: 7W-GK3319

2-(Acetamido)-2-deoxy-β-D-mannopyranose

CAS: 7772-94-3

2-(Acetamido)-2-deoxy-β-D-mannopyranose

Pureza: 97% (Monohydrate)

Peso molecular: 221.21g/mol

Ref: 54-OR8153

N-Acetyl-D-mannosamine

CAS: 7772-94-3

N-Acetyl-D-mannosamine

Cor e Forma: White To Off White Powder

Peso molecular: 239.22g/mol

Ref: 54-BIA1221

Cyclic N-Acetyl-D-mannosamine

CAS: 7772-94-3

Cyclic N-Acetyl-D-mannosamine is used for sialic acid synthesis and as a precursor for biologically active compounds.

Fórmula: C₈H₁₅NO₆

Pureza: 99.18% - 99.72%

Cor e Forma: White Crystal Powder

Peso molecular: 221.21

Ref: TM-T4725

N-Acetyl-D-mannosamine

CAS: 7772-94-3

N-Acetyl D-mannosamine (ManNAc) is an aldohexose (2-acetamido-2-deoxymannose) in which the axial hydroxyl group at position 2 is replaced by a N-acetyl group (Collins, 2006). It has been reported that N-acetyl D-mannosamine supplementation, may provide novel means to break the link between obesity and hypertension (Peng, 2019). N-Acetyl-D-mannosamine and N-acetyl-D-glucosamine are the essential precursors of sialic acid, the specific monomer of polysialic acid, a bacterial pathogenic determinant, for example, Escherichia coli K1 uses both amino sugars as carbon sources. Glycoproteins normally have some level of glycan sialylation, but incomplete sialylation can reduce their therapeutic effect when produced recombinantly. To improve performance, cell lines and culture media can be adjusted. The GNE enzyme controls the efficiency of sialylation in human cell lines, making it crucial for producing effective recombinant glycoprotein drugs. Adding ManNAc and other supplements to culture media improves sialylation, which boosts drug yield, increases stability and half-life, and lowers immune reactions by reducing antibody formation.It has also been reported that ManNAc can be used as a treatment for hereditary inclusion body myopathy, an adult-onset, progressive neuromuscular disorder and also for renal disorders involving proteinuria and hematuria due to podocytopathy and/or segmental splitting of the glomerular basement membrane (Galeano, 2007).

Fórmula: C₈H₁₅NO₆

Pureza: Min. 97.5 Area-%

Peso molecular: 221.21 g/mol

Ref: 3D-Z-1000

N-Acetyl-D-mannosamine - low endotoxin grade

CAS: 7772-94-3

Please enquire for more information about N-Acetyl-D-mannosamine - low endotoxin grade including the price, delivery time and more detailed product information at the technical inquiry form on this page

Fórmula: C₈H₁₅NO₆

Peso molecular: 221.21 g/mol

Ref: 3D-Z-1082

N-Acetyl-D-mannosamine

CAS: 7772-94-3

Pureza: 95%

Peso molecular: 221.21

Ref: 10-F493709

N-Acetyl-D-mannosamine

CAS: 7772-94-3

N-Acetyl D-mannosamine (ManNAc) is an aldohexose (2-acetamido-2-deoxymannose) in which the axial hydroxyl group at position 2 is replaced by a N-acetyl group (Collins, 2006). It has been reported that N-acetyl D-mannosamine supplementation, may provide novel means to break the link between obesity and hypertension (Peng, 2019). N-Acetyl-D-mannosamine and N-acetyl-D-glucosamine are the essential precursors of sialic acid, the specific monomer of polysialic acid, a bacterial pathogenic determinant, for example, Escherichia coli K1 uses both amino sugars as carbon sources. It has been reported that ManNAc can be used as a treatment for hereditary inclusion body myopathy, an adult-onset, progressive neuromuscular disorder and also for renal disorders involving proteinuria and hematuria due to podocytopathy and/or segmental splitting of the glomerular basement membrane (Galeano, 2007).

Fórmula: C₈H₁₅NO₆

Pureza: Min. 98 Area-%

Cor e Forma: White Powder

Peso molecular: 221.21 g/mol

Ref: 3D-MA05269