CAS 78432-77-6

10-Desacetiltaxol

Descrição:

10-Desacetiltaxol, com o número CAS 78432-77-6, é um derivado do produto natural taxol, conhecido por suas propriedades anticancerígenas. Este composto é caracterizado pela ausência de um grupo acetil na posição C10, o que o distingue do taxol. Apresenta uma estrutura policíclica complexa típica dos taxanos, com um núcleo de taxano que contribui para sua atividade biológica. 10-Desacetiltaxol é reconhecido principalmente por sua capacidade de estabilizar microtúbulos, inibindo assim a divisão celular, que é um mecanismo crucial no tratamento do câncer. O composto é frequentemente estudado por suas potenciais aplicações terapêuticas e pode apresentar diferentes graus de citotoxicidade contra diferentes linhagens celulares cancerosas. Além disso, sua solubilidade e estabilidade em sistemas biológicos podem influenciar sua eficácia como agente terapêutico. No geral, 10-Desacetiltaxol representa um composto importante no campo da química medicinal, particularmente no desenvolvimento de agentes quimioterapêuticos.

Fórmula: C₄₅H₄₉NO₁₃

InChI: InChI=1S/C45H49NO13/c1-24-29(57-41(54)35(50)33(26-15-9-6-10-16-26)46-39(52)27-17-11-7-12-18-27)22-45(55)38(58-40(53)28-19-13-8-14-20-28)36-43(5,37(51)34(49)32(24)42(45,3)4)30(48)21-31-44(36,23-56-31)59-25(2)47/h6-20,29-31,33-36,38,48-50,55H,21-23H2,1-5H3,(H,46,52)/t29-,30-,31+,33-,34+,35+,36-,38-,43+,44-,45+/m0/s1

Chave InChI: InChIKey=TYLVGQKNNUHXIP-MHHARFCSSA-N

SMILES: O(C(C)=O)[C@]12[C@]3([C@H](OC(=O)C4=CC=CC=C4)[C@@]5(O)C(C)(C)C([C@@H](O)C(=O)[C@]3(C)[C@@H](O)C[C@]1(OC2)[H])=C(C)[C@@H](OC([C@@H]([C@@H](NC(=O)C6=CC=CC=C6)C7=CC=CC=C7)O)=O)C5)[H]

Sinónimos:

• (2alpha,5beta,7beta,10beta,13alpha)-4-(acetyloxy)-13-{[(2R,3S)-3-(benzoylamino)-2-hydroxy-3-phenylpropanoyl]oxy}-1,7,10-trihydroxy-9-oxo-5,20-epoxytax-11-en-2-yl benzoate
• 10-Deacetylpaclitaxel
• 10-Deacetyltaxol
• 10-Deacetyltaxol A
• 10-Desacetylpaclitaxel
• 10-Desacetyltaxol
• 10-O-Deacetyltaxol
• 7,11-Methano-1H-cyclodeca[3,4]benz[1,2-b]oxete, benzenepropanoic acid deriv.
• 7-Epi-10-deacetyl paclitaxel
• Benzenepropanoic acid, β-(benzoylamino)-α-hydroxy-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, (αR,βS)-
• Benzenepropanoic acid, β-(benzoylamino)-α-hydroxy-, 12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, [2aR-[2aα,4β,4aβ,6β,9α(αR*,βS*),11α,12α,12aα,12bα]]-

Paclitaxel EP Impurity G (10-Desacetyl Paclitaxel)

CAS: 78432-77-6

Fórmula: C₄₅H₄₉NO₁₃

Cor e Forma: Pink Solid

Peso molecular: 811.88

Ref: 4Z-P-286

10-Deacetyltaxol

CAS: 78432-77-6

Fórmula: C₄₅H₄₉NO₁₃

Pureza: ≥ 98.0%

Cor e Forma: White to off-white powder

Peso molecular: 811.88

Ref: 7W-GY7900

10-Deacetyltaxol

CAS: 78432-77-6

10-Deacetyltaxol

Pureza: ≥90%

Peso molecular: 811.87g/mol

Ref: 54-BUP00167

10-Deacetyltaxol

CAS: 78432-77-6

10-Deacetyltaxol and cephalomannine have cytotoxicity in human glial and neuroblastoma cell-lines, the tumors of the central and peripheral nervous system are sensitive to 10-deacetyltaxol and cephalomannine and these drugs are less toxic than taxol but remain within a therapeutic range.

Fórmula: C₄₅H₄₉NO₁₃

Pureza: 95%~99%

Peso molecular: 811.881

Ref: BP-BP0012

10-Deacetyltaxol

CAS: 78432-77-6

10-Deacetyltaxol (10-DAT) is extracted from Taxus brevifolia barks.

Fórmula: C₄₅H₄₉NO₁₃

Pureza: 94.63% - 99.93%

Cor e Forma: Solid

Peso molecular: 811.87

Ref: TM-T5165

10-Deacetyltaxol

CAS: 78432-77-6

Peso molecular: 811.881

Ref: 10-F986787

10-Desacetyl Paclitaxel

CAS: 78432-77-6

Impurity Paclitaxel - impurity G
Applications A semi-synthetic precursor of Paclitaxel. Paclitaxel - impurity G.

Fórmula: C₄₅H₄₉NO₁₃

Cor e Forma: White To Off-White

Peso molecular: 811.87

Ref: TR-D288710

10-Desacetyl paclitaxel

CAS: 78432-77-6

10-Desacetyl paclitaxel is a form of paclitaxel that has been modified chemically. It is soluble in water and can be injected intravenously. 10-Desacetyl paclitaxel is used to treat inflammatory diseases, such as rheumatoid arthritis and psoriasis. This drug binds to the hydroxyl groups on the surface of the bacterial cell wall and prevents the formation of covalent linkages with polysaccharides, which leads to its increased patency in bacterial cells. 10-Desacetyl paclitaxel has also been shown to inhibit the activity of certain enzymes that are involved in synthesis of DNA, RNA, and proteins. This inhibition results in cell death by apoptosis or necrosis. The increase in viability after treatment with 10-desacetyl paclitaxel was observed for both gram-positive bacteria (e.g., Bacillus subtilis) and gram-negative bacteria (e.g., Escher

Fórmula: C₄₅H₄₉NO₁₃

Pureza: Min. 95%

Cor e Forma: White Powder

Peso molecular: 811.87 g/mol

Ref: 3D-FD21126

Paclitaxel EP Impurity G

CAS: 78432-77-6

Fórmula: C₄₅H₄₉NO₁₃

Peso molecular: 811.88

Ref: ST-EA-CP-P36007