CAS 789-61-7

2'-Desoxi-6-tioguanosina

Descrição:

2'-Desoxi-6-tioguanosina é um análogo de nucleosídeo que apresenta um grupo tiol na posição 6 da base de guanina, substituindo o oxigênio típico encontrado em nucleosídeos padrão. Essa modificação confere propriedades bioquímicas únicas, tornando-o de interesse em várias áreas, incluindo química medicinal e biologia molecular. O composto consiste em um açúcar desoxirribose ligado a uma base de guanina modificada, que pode participar da síntese de ácidos nucleicos e potencialmente interferir com os processos celulares normais. Sua estrutura permite que seja incorporado ao DNA, onde pode afetar a replicação e a transcrição. 2'-Desoxi-6-tioguanosina tem sido estudado por suas potenciais aplicações terapêuticas, particularmente no contexto de tratamentos antivirais e anticâncer, pois pode imitar nucleosídeos naturais e interromper a função dos ácidos nucleicos em patógenos ou células cancerosas. Além disso, seu único grupo tiol pode participar de reações redox, influenciando as vias de sinalização celular. No geral, este composto representa uma área significativa de pesquisa devido ao seu potencial para modular sistemas biológicos.

Fórmula: C₁₀H₁₃N₅O₃S

InChI: InChI=1S/C10H13N5O3S/c11-10-13-8-7(9(19)14-10)12-3-15(8)6-1-4(17)5(2-16)18-6/h3-6,16-17H,1-2H2,(H3,11,13,14,19)/t4-,5+,6+/m0/s1

Chave InChI: InChIKey=SCVJRXQHFJXZFZ-KVQBGUIXSA-N

SMILES: S=C1C2=C(N(C=N2)[C@@H]3O[C@H](CO)[C@@H](O)C3)NC(N)=N1

Sinónimos:

• 2′-Deoxythioguanosine
• Thioguanine deoxyriboside
• Guanosine, 2′-deoxy-6-thio-
• 2′-Deoxy-6-thioguanosine
• 9H-Purine-6(1H)-thione, 2-amino-9-(2-deoxy-β-D-erythro-pentofuranosyl)-

6-Thio-2'-Deoxyguanosine

CAS: 789-61-7

Fórmula: C₁₀H₁₃N₅O₃S

Pureza: 98%

Cor e Forma: Solid

Peso molecular: 283.3069

Ref: IN-DA00G38M

2''-Deoxy-6-thioguanosine

CAS: 789-61-7

Ref: 7W-GN2065

6-Thio-2'-Deoxyguanosine

CAS: 789-61-7

6-Thio-2'-Deoxyguanosine

Pureza: ≥95%

Peso molecular: 283.31g/mol

Ref: 54-BUP06562

6-Thio-2'-Deoxyguanosine

CAS: 789-61-7

6-Thio-2'-Deoxyguanosine (β-TGdR) is a nucleoside analog and telomerase substrate.

Fórmula: C₁₀H₁₃N₅O₃S

Pureza: 97.52%

Cor e Forma: Solid

Peso molecular: 283.31

Ref: TM-T6746

2′-Deoxy-6-Thio-Guanosine

CAS: 789-61-7

Fórmula: C₁₀H₁₃N₅O₃S

Peso molecular: 283.31

Ref: 4Z-G-2462

2'-Deoxy-6-thio Guanosine

Produto Controlado

CAS: 789-61-7

Applications Guanosine (G837900) derivative with cancer chemotherapeutic properties. It is involved in the inhibition of human RNase H-mediated RNA cleavage from DNA-RNA duplexes via incorporation into DNA.
References Momparler, R.L. et al.: Cancer Treat. Rep., 62, 135 (1978); Krynetskaia, N.F. et al.: Mol. Pharmacol., 56, 841 (1999);

Fórmula: C₁₀H₁₃N₅O₃S

Cor e Forma: Neat

Peso molecular: 283.31

Ref: TR-D281650

2'-Deoxy-6-thioguanosine

CAS: 789-61-7

2'-Deoxy-6-thioguanosine is a purine nucleoside analog that inhibits the activation of transcription factors such as nuclear factor kappa-B (NF-κB) and activator protein 1 (AP-1). It also inhibits the synthesis of proinflammatory cytokines, such as IL-1β, IL-6, and TNFα. The matrix effect is an important factor in the prevention of tumor progression. 2'-Deoxy-6-thioguanosine has been shown to inhibit cell proliferation and induce apoptosis in squamous cell carcinoma cells by modulating the expression of HLA class II molecules on tumors. It also prevents invasion by blocking matrix metalloproteinase activity. 2'-Deoxy-6-thioguanosine has been found to be effective against bowel diseases such as ulcerative colitis and Crohn's disease, as well as infectious diseases such as HIV/AIDS.

Fórmula: C₁₀H₁₃N₅O₃S

Pureza: Min. 97 Area-%

Cor e Forma: Powder

Peso molecular: 283.31 g/mol

Ref: 3D-ND08563

2'-Deoxy-6-thioguanosine - Bio-X ™

CAS: 789-61-7

This product is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.

Fórmula: C₁₀H₁₃N₅O₃S

Pureza: Min. 95%

Cor e Forma: Powder

Peso molecular: 283.31 g/mol

Ref: 3D-BD300155

6-Thio-2′-deoxyguanosine

CAS: 789-61-7

Pureza: 98%

Peso molecular: 283.310

Ref: 10-F980551

2'-Deoxy-6-thio Guanosine-13C, 15N2

Produto Controlado

CAS: 789-61-7

Applications 2'-Deoxy-6-thio Guanosine-13C, 15N2 is labelled 2'-Deoxy-6-thio Guanosine (D281650) which is a Guanosine (G837900) derivative with cancer chemotherapeutic properties. It is involved in the inhibition of human RNase H-mediated RNA cleavage from DNA-RNA duplexes via incorporation into DNA.
References Momparler, R.L. et al.: Cancer Treat. Rep., 62, 135 (1978); Krynetskaia, N.F. et al.: Mol. Pharmacol., 56, 841 (1999)

Fórmula: CC₉H₁₃₁₅N₂N₃O₃S

Cor e Forma: Neat

Peso molecular: 286.286

Ref: TR-D281652