CAS 79794-75-5

Loratadina

Descrição:

Loratadina é um antihistamínico de segunda geração comumente usado para aliviar os sintomas de alergia, como nariz escorrendo, espirros e olhos coçando. É caracterizado pelo seu antagonismo seletivo dos receptores H1 periféricos, o que ajuda a minimizar os efeitos colaterais comuns associados aos antihistamínicos de primeira geração, como a sedação. Loratadina é um pó cristalino branco a quase branco que é praticamente insolúvel em água, mas solúvel em solventes orgânicos como etanol e metanol. Sua fórmula química é C22H23ClN2O2, e tem um peso molecular de aproximadamente 382,88 g/mol. Loratadina é frequentemente administrado por via oral e tem uma longa duração de ação, permitindo a dosagem uma vez ao dia. É metabolizado no fígado em seu metabolito ativo, desLoratadina, que contribui para seus efeitos antihistamínicos. Devido à sua baixa penetração da barreira hematoencefálica, Loratadina é menos provável que cause sonolência em comparação com antihistamínicos mais antigos, tornando-se uma escolha preferida para indivíduos que precisam de alívio dos sintomas alérgicos sem sedação.

Fórmula: C₂₂H₂₃ClN₂O₂

InChI: InChI=1S/C22H23ClN2O2/c1-2-27-22(26)25-12-9-15(10-13-25)20-19-8-7-18(23)14-17(19)6-5-16-4-3-11-24-21(16)20/h3-4,7-8,11,14H,2,5-6,9-10,12-13H2,1H3

Chave InChI: InChIKey=JCCNYMKQOSZNPW-UHFFFAOYSA-N

SMILES: ClC=1C=C2C(C(C=3C(CC2)=CC=CN3)=C4CCN(C(OCC)=O)CC4)=CC1

Sinónimos:

• 1-Piperidinecarboxylic acid, 4-(8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-, ethyl ester
• 11H-Benzo[5,6]cyclohepta[1,2-b]pyridine, 1-piperidinecarboxylic acid deriv.
• 4-(8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene-1-piperidinecarboxylic acid ethyl ester
• Alavert
• Anhissen
• Bonalerg
• Civeran
• Claratyne
• Claritin
• Claritine
• Clarityn
• Clarityne
• Clarotadin
• Cronopen
• Erolin
• Ethyl 4-(8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-1-piperidinecarboxylate
• Flonidan
• Fristamin
• Histaloran
• Klarifer
• Klaritin
• Lertamine
• Lisino
• Lomilan
• Loracert
• Loradex
• Loranox
• Lorastine
• Loratidine
• Loratyne
• Lorfast
• Lowadina
• Optimin
• Polaratyne
• Pylor
• Restamine
• Sch 29851
• Sensibit
• Sohotin
• Symphoral
• Tadine
• Velodan
• Zeos

Loratadine

CAS: 79794-75-5

Fórmula: C₂₂H₂₃ClN₂O₂

Pureza: >98.0%(T)(HPLC)

Cor e Forma: White to Almost white powder to crystal

Peso molecular: 382.89

Ref: 3B-L0223

Loratadine, 98+%

CAS: 79794-75-5

A nonsedating-type histamine H1-receptor antagonist

Fórmula: C₂₂H₂₃ClN₂O₂

Pureza: 98+%

Peso molecular: 382.89

Ref: 02-J60190

Loratadine

CAS: 79794-75-5

Cor e Forma: Neat

Ref: 61-FOR0257.00

Loratadine 0.1 mg/ml in Methanol

CAS: 79794-75-5

Cor e Forma: Single Solution

Ref: 61-AMP0257.00-02

Loratadine

CAS: 79794-75-5

Loratadine

Fórmula: C₂₂H₂₃ClN₂O₂

Pureza: 99.6%

Cor e Forma: White

Peso molecular: 382.14481

Ref: 47-874

LORATADINE FOR SYSTEM SUITABILITY CRS

CAS: 79794-75-5

LORATADINE FOR SYSTEM SUITABILITY CRS

Fórmula: C₂₂H₂₃ClN₂O₂

Peso molecular: 382.8832

Ref: 41-Y0000603

Loratadine impurity standard

CAS: 100643-71-8, 79794-75-5

Loratadine impurity standard

Cor e Forma: White

Ref: 47-875

LORATADINE CRS

CAS: 79794-75-5

LORATADINE CRS

Fórmula: C₂₂H₂₃ClN₂O₂

Peso molecular: 382.8832

Ref: 41-Y0000688

Loratadine

CAS: 79794-75-5

Compounds containing an unfused pyridine ring in the structure, nesoi

Fórmula: C₂₂H₂₃ClN₂O₂

Cor e Forma: White Off-White Powder

Peso molecular: 382.88

Ref: 45-1370270

Loratadine

CAS: 79794-75-5

Loratadine (SCH 29851) is a second-generation histamine H1 receptor antagonist used in the treatment of allergic rhinitis and urticaria.

Fórmula: C₂₂H₂₃ClN₂O₂

Pureza: 99.71% - 99.98%

Cor e Forma: White Powder

Peso molecular: 382.88

Ref: TM-T1097

Loratadine (Desloratadine EP Impurity C)

CAS: 79794-75-5

Fórmula: C₂₂H₂₃ClN₂O₂

Cor e Forma: White To Off-White Solid

Peso molecular: 382.89

Ref: 4Z-L-101

Loratadine

CAS: 79794-75-5

Loratadine

Pureza: 98%

Peso molecular: 382.88g/mol

Ref: 54-OR1029319

Loratadine, USP grade

CAS: 79794-75-5

Fórmula: C₂₂H₂₃ClN₂O₂

Pureza: 98.5 - 101.0 % (dry basis)

Cor e Forma: White to off-white powder

Peso molecular: 382.88

Ref: 7W-GP3491

Loratadine

CAS: 79794-75-5

Loratadine

Pureza: ≥98%

Peso molecular: 382.88g/mol

Ref: 54-BUP18588

Loratadine-d5 (ethyl-d5)

CAS: 1398065-63-8, 79794-75-5

Pureza: 99 atom % D

Cor e Forma: White Solid

Peso molecular: 387.92

Ref: 3U-D7392

Loratadine

CAS: 79794-75-5

Cor e Forma: Neat

Ref: 86-MM0257.00

Loratadine Impurity 39

CAS: 79794-75-5

Fórmula: C₂₀H₂₃ClN₂O

Peso molecular: 342.87

Ref: 4Z-L-10107

Loratadine Impurity 44

CAS: 79794-75-5

Fórmula: C₂₀H₁₉ClN₂O

Peso molecular: 338.84

Ref: 4Z-L-10112

Loratadine

CAS: 79794-75-5

Fórmula: C₂₂H₂₃ClN₂O₂

Pureza: ≥ 98.0% (dried basis)

Cor e Forma: White or almost white powder

Peso molecular: 382.88

Ref: 7W-GP7681

Loratadine

Produto Controlado

CAS: 79794-75-5

Applications A nonsedating-type histamine H1-receptor.
References Bruttmann, G., et al.: J. Allergy Clin. Immunol., 83, 411 (1989), Haria, M., et al.: Drugs, 48, 617 (1994)

Fórmula: C₂₂H₂₃ClN₂O₂

Cor e Forma: White

Peso molecular: 382.88

Ref: TR-L469575

Desloratadine EP Impurity C

CAS: 79794-75-5

Fórmula: C₂₂H₂₃ClN₂O₂

Peso molecular: 382.88

Ref: ST-EA-CP-D15003

Loratadine - Bio-X ™

CAS: 79794-75-5

Loratadine is a non-sedating, inverse agonist antihistamine used for the treatment of allergic rhinitis, an IgE (immunoglobulin E) mediated disease. Loratadine binds to histamine H1 receptors, preventing histamine from binding and causing an allergic reaction.It has been found to inhibit the release of eosinophil cationic protein by acting on different components of allergic inflammation, in particular in the modulation of ICAM-1 expression on nasal epithelial cells as a mechanism of protective for the epithelium, and therefore, the damage of mucosa is reduced. In recent studies, it was found that loratadine is a potent HR1 antagonist with in vitro inhbitory effect on human mast-cell lines, HMC-1 (from mast cell leukaemia) with an IC50 between 10 and 50 μM.Loratadine is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready to use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.

Fórmula: C₂₂H₂₃ClN₂O₂

Pureza: Min. 95%

Cor e Forma: Powder

Peso molecular: 382.88 g/mol

Ref: 3D-BL164637

Loratadine

CAS: 79794-75-5

Loratadine is a non-sedating, inverse agonist antihistamine used for the treatment of allergic rhinitis, an IgE (immunoglobulin E) mediated disease. Loratadine binds to histamine H1 receptors, preventing histamine from binding and causing an allergic reaction.It has been found to inhibit the release of eosinophil cationic protein by acting on different components of allergic inflammation, in particular in the modulation of ICAM-1 expression on nasal epithelial cells as a mechanism of protective for the epithelium, and therefore, the damage of mucosa is reduced. In recent studies, it was found that loratadine is a potent HR1 antagonist with in vitro inhbitory effect on human mast-cell lines, HMC-1 (from mast cell leukaemia) with an IC50 between 10 and 50 μM.

Fórmula: C₂₂H₂₃ClN₂O₂

Pureza: 98.5 To 101.0%

Cor e Forma: Powder

Peso molecular: 382.88 g/mol

Ref: 3D-FL24933

11-(N-Hydroxy) Loratadine 1-Oxide

Produto Controlado

CAS: 79794-75-5

Fórmula: C₁₉H₁₉ClN₂O₂

Cor e Forma: Neat

Peso molecular: 342.819

Ref: TR-H947746