CAS 79952-44-6

Epilovastatina

Descrição:

Epilovastatina, com o número CAS 79952-44-6, é um composto sintético que pertence à classe das estatinas, que são usadas principalmente por suas propriedades de redução do colesterol. Funciona inibindo a enzima HMG-CoA redutase, um jogador chave na biossíntese de colesterol no fígado. Essa ação ajuda a reduzir os níveis de lipoproteína de baixa densidade (LDL) e triglicerídeos, enquanto potencialmente aumenta o colesterol de lipoproteína de alta densidade (HDL). Epilovastatina é caracterizado por sua estrutura química específica, que inclui um anel de lactona e vários grupos funcionais que contribuem para sua atividade biológica. É tipicamente administrado por via oral e foi estudado por sua eficácia no manejo da hiperlipidemia e na redução do risco cardiovascular. Assim como outras estatinas, os efeitos colaterais potenciais podem incluir dor muscular, alterações nas enzimas hepáticas e distúrbios gastrointestinais. Sua farmacocinética, incluindo absorção, metabolismo e excreção, é importante para determinar os regimes de dosagem e entender suas interações com outros medicamentos.

Fórmula: C₂₄H₃₆O₅

InChI: InChI=1/C24H36O5/c1-5-15(3)24(27)29-21-11-14(2)10-17-7-6-16(4)20(23(17)21)9-8-19-12-18(25)13-22(26)28-19/h6-7,10,14-16,18-21,23,25H,5,8-9,11-13H2,1-4H3/t14?,15?,16-,18+,19+,20-,21?,23-/m0/s1

Chave InChI: InChIKey=PCZOHLXUXFIOCF-YPQFMRJXSA-N

SMILES: O(C([C@@H](CC)C)=O)[C@@H]1[C@]2(C(C=C[C@H](C)[C@@H]2CC[C@@H]3C[C@@H](O)CC(=O)O3)=C[C@H](C)C1)[H]

Sinónimos:

• Epilovastatin
• Butanoic acid, 2-methyl-, (1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl ester, (2R)-
• Butanoic acid, 2-methyl-, 1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-[2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl]-1-naphthalenyl ester, [1S-[1α(S*),3α,7β,8β(2S*,4S*),8aβ]]-
• Lovastatin epi-Isomer
• Simvastatin EP Impurity F/ Simvastatin Related Compound F (epi-Lovastatin/ Lovastatin epimer)
• Epilovastatin, 10 - 15% isoMers
• (1S,3R,7S,8S,8aR)-8-[2-[(2R,4R)-4-Hydroxy-6-oxotetrahydro-2H-pyran-2-yl]ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl (2R)-2-methylbutanoate
• Epi Lovastatin
• (1S,3R,7S,8S,8aR)-8-[2-[(2R,4R)-4-H
• Simvastatin Impurity 6（EP-F）
• (R)-(1S,3R,7S,8S,8aR)-8-(2-((2R,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl)ethyl)-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl 2-methylbutanoate
• Simvastatin EP Impurity F (epi-Lovastatin)
• Epilovastatin, 95%, 10 - 15% isomers
• (2R)-2-Methylbutanoic acid (1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl ester
• Simvastatin EP Impurity
• Simvastatin EP Impurity F (epi-Lovastatin)/(2R)-2-Methylbutanoic Acid (1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-Hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl
• Simvastatin Impurity 6(Simvastatin EP Impurity F)

Epi Lovastatin ((1S,3R,7S,8S,8aR)-8-[2-[(2R,4R)-4-Hydroxy-6-oxotetrahydro-2H-pyran-2-yl]ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl (2R)-2-methylbutanoate)

CAS: 79952-44-6

Lactones, nesoi

Fórmula: C₂₄H₃₆O₅

Cor e Forma: White Powder

Peso molecular: 404.25627

Ref: 45-1A10320

Simvastatin EP Impurity F (epi-Lovastatin)

CAS: 79952-44-6

Fórmula: C₂₄H₃₆O₅

Cor e Forma: White To Off-White Solid

Peso molecular: 404.55

Ref: 4Z-S-128

(1S,3R,7S,8S,8aR)-8-[2-[(2R,4R)-4-Hydroxy-6-oxotetrahydro-2H-pyran-2-yl]ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl (2R)-2-Methylbutanoate (Epilovastatin)

CAS: 79952-44-6

Fórmula: C₂₄H₃₆O₅

Cor e Forma: Neat

Peso molecular: 404.54

Ref: 86-MM0158.06

Epi Lovastatin

CAS: 79952-44-6

Fórmula: C₂₄H₃₆O₅

Peso molecular: 404.5

Ref: ST-EA-CP-L76020

Simvastatin EP Impurity F

CAS: 79952-44-6

Fórmula: C₂₄H₃₆O₅

Peso molecular: 404.55

Ref: ST-EA-CP-S4006

Epi Lovastatin

Produto Controlado

CAS: 79952-44-6

Impurity Simvastatin EP Impurity F
Applications Epi Lovastatin (Simvastatin EP Impurity F) is a Lovastatin impurity; an antihypercholesterolemic compound.
References Hoffman, W.F., et al.: J. Med. Chem., 29, 849 (1986),

Fórmula: C₂₄H₃₆O₅

Cor e Forma: Neat

Peso molecular: 404.54

Ref: TR-E588530

Epi lovastatin

CAS: 79952-44-6

Lovastatin is a cholesterol-lowering drug that acts by inhibiting the enzyme HMG-CoA reductase. It is also used to prevent organ rejection after a liver transplant, and has been shown to have anti-aging effects. Lovastatin has been shown to reduce serum cholesterol levels, which may be due to its ability to inhibit cellular proliferation in rat hepatocytes. This drug has been shown to have an effect on DNA damage and post-translational modification of proteins, as well as on health care foods. Lovastatin is a member of the statins family of drugs, which are all natural products isolated from fungi or bacteria. The active form of lovastatin is made in the laboratory by chemical synthesis, using recombinant DNA technology. The recombinant gene encoding lovastatin was cloned into an expression vector and expressed in Escherichia coli cells (E.M.).

Fórmula: C₂₄H₃₆O₅

Pureza: Min. 95%

Peso molecular: 404.54 g/mol

Ref: 3D-IE22709