CAS 80418-24-2
:Notoginsenoside R1
Descrição:
Notoginsenoside R1 é uma saponina triterpenoide derivada principalmente das raízes de Panax notoginseng, uma planta conhecida por suas propriedades medicinais na medicina tradicional chinesa. Este composto é caracterizado por sua estrutura complexa, que inclui uma espinha dorsal semelhante a um esteroide com múltiplos grupos hidroxila e um grupo de açúcar, contribuindo para sua bioatividade. Notoginsenoside R1 exibe vários efeitos farmacológicos, incluindo propriedades anti-inflamatórias, antioxidantes e neuroprotetoras. Foi estudado por seu potencial em melhorar a função cognitiva e promover a saúde cardiovascular. O composto é tipicamente solúvel em solventes orgânicos e apresenta baixa solubilidade em água, o que pode influenciar sua biodisponibilidade e eficácia terapêutica. Além disso, Notoginsenoside R1 é frequentemente investigado por seu papel na modulação de vias de sinalização relacionadas à sobrevivência celular e apoptose, tornando-se um assunto de interesse na pesquisa farmacológica. No geral, Notoginsenoside R1 representa um componente significativo de Panax notoginseng, contribuindo para seus benefícios à saúde e aplicações terapêuticas.
Fórmula:C47H80O18
InChI:InChI=1S/C47H80O18/c1-21(2)10-9-13-47(8,65-41-37(59)34(56)32(54)26(18-48)62-41)22-11-15-45(6)30(22)23(50)16-28-44(5)14-12-29(52)43(3,4)39(44)25(17-46(28,45)7)61-42-38(35(57)33(55)27(19-49)63-42)64-40-36(58)31(53)24(51)20-60-40/h10,22-42,48-59H,9,11-20H2,1-8H3/t22-,23+,24+,25-,26+,27+,28+,29-,30-,31-,32+,33+,34-,35-,36+,37+,38+,39-,40-,41-,42+,44+,45+,46+,47-/m0/s1
Chave InChI:InChIKey=LLPWNQMSUYAGQI-OOSPGMBYSA-N
SMILES:C[C@]12[C@@]3(C)[C@@]([C@@]([C@@](O[C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O)(CCC=C(C)C)C)(CC3)[H])([C@H](O)C[C@@]1([C@]5(C)[C@@]([C@@H](O[C@H]6[C@H](O[C@H]7[C@H](O)[C@@H](O)[C@H](O)CO7)[C@@H](O)[C@H](O)[C@@H](CO)O6)C2)(C(C)(C)[C@@H](O)CC5)[H])[H])[H]
Sinónimos:- (3beta,6alpha,12beta)-20-(beta-D-glucopyranosyloxy)-3,12-dihydroxydammar-24-en-6-yl 2-O-beta-D-xylopyranosyl-beta-D-glucopyranoside
- (3β,6α,12β)-20-(β-<span class="text-smallcaps">D</smallcap>-Glucopyranosyloxy)-3,12-dihydroxydammar-24-en-6-yl 2-O-β-<smallcap>D</smallcap>-xylopyranosyl-β-<smallcap>D</span>-glucopyranoside
- (6beta,8xi,9xi,12alpha,13xi,14beta)-17-[(1S)-1-(beta-D-glucopyranosyloxy)-1,5-dimethylhex-4-en-1-yl]-3,12-dihydroxy-4,4,10,14-tetramethylgonan-6-yl 2-O-beta-D-xylopyranosyl-beta-D-glucopyranoside
- Dammarane, β-<span class="text-smallcaps">D</span>-glucopyranoside deriv.
- Netoginsenoside
- Notoginsenoside R 1
- Notoginsenoside R1
- Notoginsenoside R<sub>1</sub>
- Sanchinoside R<sub>1</sub>
- Sanqi glucoside R1
- beta-D-Glucopyranoside, (3beta,6alpha,12beta)-20-(beta-D-glucopyranosyloxy)-3,12-dihydroxydammar-24-en-6-yl 2-O-beta-D-xylopyranosyl-
- β-<span class="text-smallcaps">D</smallcap>-Glucopyranoside, (3β,6α,12β)-20-(β-<smallcap>D</smallcap>-glucopyranosyloxy)-3,12-dihydroxydammar-24-en-6-yl 2-O-β-<smallcap>D</span>-xylopyranosyl-
- (3β,6α,12β)-20-(β-D-Glucopyranosyloxy)-3,12-dihydroxydammar-24-en-6-yl 2-O-β-D-xylopyranosyl-β-D-glucopyranoside
- Sanchinoside R1
- β-D-Glucopyranoside, (3β,6α,12β)-20-(β-D-glucopyranosyloxy)-3,12-dihydroxydammar-24-en-6-yl 2-O-β-D-xylopyranosyl-
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12 produtos.
Notoginsenoside R1
CAS:Fórmula:C47H80O18Pureza:>98.0%(HPLC)Cor e Forma:White to Almost white powder to crystalPeso molecular:933.14Notoginsenoside R1
CAS:Notoginsenoside R1 analytical standard provided with w/w absolute assay, to be used for quantitative titration.Fórmula:C47H80O18Pureza:(HPLC) ≥98%Cor e Forma:PowderPeso molecular:933.15b-D-Glucopyranoside,(3b,6a,12b)-20-(b-D-glucopyranosyloxy)-3,12-dihydroxydammar-24-en-6-yl 2-O-b-D-xylopyranosyl-
CAS:Fórmula:C47H80O18Pureza:98%Cor e Forma:SolidPeso molecular:933.1273Notoginsenoside R1
CAS:Notoginsenoside R1(NR1) is the main ingredient with cardiovascular activity in Panax notoginseng, which has some neuronal protective, antihypertensive,antioxidant, anti-inflammatory, antiapoptotic, and immune-stimulatory activities. NR1 can counteract endotoxin-induced activation of endothelial cells in vitro and endotoxin-induced lethality in mice in vivo. NR1 inhibits TNF-α-induced PAI-1 overexpression via extracellular signal-related kinases (ERK1/2) and phosphatidylinositol 3-kinase (PI3K)/protein kinase B (PKB) signaling pathways, it attenuates amyloid-β-induced damage in neurons by inhibiting reactive oxygen species and modulating MAPK activation.Fórmula:C47H80O18Pureza:95%~99%Peso molecular:933.139Notoginsenoside R1
CAS:Notoginsenoside R1 (Sanchinoside R1) has been shown to exhibit antioxidant, antiapoptotic, anti-inflammatory, and immune-stimulatory properties.Fórmula:C47H80O18Pureza:99.69% - 99.91%Cor e Forma:SolidPeso molecular:933.13Notoginsenoside r1
CAS:Natural glycosideFórmula:C47H80O18Pureza:≥ 90.0 % (HPLC)Cor e Forma:PowderPeso molecular:933.14Notoginsenoside R1
CAS:<p>Notoginsenoside R1 is a saponin compound, which is a key bioactive ingredient derived from the roots of Panax notoginseng, a well-known traditional medicinal plant. This product is renowned for its diverse pharmacological activities, particularly its anti-inflammatory and antioxidant effects. The mode of action of Notoginsenoside R1 involves modulating various signaling pathways, including the NF-κB and MAPK pathways, which are pivotal in regulating the body's inflammatory response. Additionally, it exhibits the ability to scavenge free radicals, contributing to its antioxidative properties.</p>Fórmula:C47H80O18Pureza:Min. 95%Cor e Forma:White PowderPeso molecular:933.15 g/molNotoginsenoside R1
CAS:Produto Controlado<p>Applications Notoginsenoside R1 acts as an anti-inflammatory agent, inhibiting TNF-α induced PAI-1 production in aortic smooth muscle cells in humans.<br>References Zhang, H. et al.: Vasc. Pharmacol., 44, 224 (2006);<br></p>Fórmula:C47H80O18Cor e Forma:NeatPeso molecular:933.13
