CAS 811803-05-1

N-[4-(1-Cianociclopentil)fenil]-2-[(4-piridinilmetil)amino]-3-piridinocarboxamida

Descrição:

N-[4-(1-Cianociclopentil)fenil]-2-[(4-piridinilmetil)amino]-3-piridinocarboxamida, com número CAS 811803-05-1, é um composto orgânico sintético caracterizado por sua complexa estrutura molecular, que inclui múltiplos anéis aromáticos e grupos funcionais. Este composto apresenta uma espinha dorsal de piridina carboxamida, conhecida por sua potencial atividade biológica, particularmente em química medicinal. A presença de um grupo cianociclopentílico e um substituinte amino piridinilmetílico sugere que pode interagir com vários alvos biológicos, possivelmente influenciando vias relacionadas ao câncer ou outras doenças. Sua solubilidade, estabilidade e reatividade dependeriam das condições específicas, como pH e solvente, devido à presença de grupos funcionais polares. Além disso, o peso molecular do composto, o ponto de fusão e as propriedades espectrais (como NMR e IR) forneceriam mais informações sobre suas características e potenciais aplicações no desenvolvimento de medicamentos ou como ferramenta de pesquisa em bioquímica. No geral, este composto representa uma classe de moléculas que poderia ser de interesse na pesquisa farmacêutica.

Fórmula: C₂₄H₂₃N₅O

InChI: InChI=1S/C24H23N5O/c25-17-24(11-1-2-12-24)19-5-7-20(8-6-19)29-23(30)21-4-3-13-27-22(21)28-16-18-9-14-26-15-10-18/h3-10,13-15H,1-2,11-12,16H2,(H,27,28)(H,29,30)

Chave InChI: InChIKey=WPEWQEMJFLWMLV-UHFFFAOYSA-N

SMILES: C(#N)C1(CCCC1)C2=CC=C(NC(=O)C3=C(NCC=4C=CN=CC4)N=CC=C3)C=C2

Sinónimos:

• 3-Pyridinecarboxamide, N-[4-(1-cyanocyclopentyl)phenyl]-2-[(4-pyridinylmethyl)amino]-
• Apatinib
• Apatinib (YN968D1)
• Apatinib mesylate
• Aptinib
• N-[4-(1-Cyanocyclopentyl)phenyl]-2-[(4-pyridinylmethyl)amino]-3-pyridinecarboxamide
• N-[4-(1-cyanocyclopentyl)phenyl]-2-[(pyridin-4-ylmethyl)amino]pyridine-3-carboxamide
• Rivoceranib
• Yn 968D1
• N-[4-(1-Cyanocyclopentyl)phenyl]-2-[(4-pyridinylmethyl)amino]pyridine-3-carboxamide

Apatinib

CAS: 811803-05-1

Fórmula: C₂₄H₂₃N₅O

Peso molecular: 397.48

Ref: 4Z-A-367001

N-(4-(1-Cyanocyclopentyl)phenyl)-2-((pyridin-4-ylmethyl)amino)nicotinamide

CAS: 811803-05-1

N-(4-(1-Cyanocyclopentyl)phenyl)-2-((pyridin-4-ylmethyl)amino)nicotinamide

Pureza: 99%

Peso molecular: 397.48g/mol

Ref: 54-OR1066769

Apatinib

Produto Controlado

CAS: 811803-05-1

Applications Apatinib is an orally available, small molecule multitargeted tyrosine kinase inhibitor. Apatinib selectively inhibits the vascular endothelial growth factor receptor-2 (VEGFR2). Apatinib functions by inhibiting VEGF-mediated endothelial cell migration and proliferation thus blocking new blood vessel formation in tumor tissue. Recent studies have shown that Apatinib enhances the efficacy of conventional chemotherapeutical drugs in side population (SP) cells and ABCB1-overexpressing leukemia cells.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Mi, Y. et al.: Cancer Res., 70, 7981 (2010); Tong, X.Z. et al.: Biochem. Pharmacol., 83, 586 (2012); Ding, J, et al.: J. Chrom B Anal. Technol. Biomed. Life Sci., 895, 108 (2012);

Fórmula: C₂₄H₂₃N₅O·CH₄O₃S

Cor e Forma: Neat

Peso molecular: 493.58

Ref: TR-A726150

Apatinib-d8

Produto Controlado

CAS: 811803-05-1

Applications Apatinib-d8 is an intermediate used in the synthesis of Apatinib-d8 Hydrochloride (A726152), which is a labelled Apatinib (A726150). Apatinib is an orally available, small molecule multitargeted tyrosine kinase inhibitor. Apatinib selectively inhibits the vascular endothelial growth factor receptor-2 (VEGFR2). Apatinib functions by inhibiting VEGF-mediated endothelial cell migration and proliferation thus blocking new blood vessel formation in tumor tissue. Recent studies have shown that Apatinib enhances the efficacy of conventional chemotherapeutical drugs in side population (SP) cells and ABCB1-overexpressing leukemia cells.
References Mi, Y. et al.: Cancer Res., 70, 7981 (2010); Tong, X.Z. et al.: Biochem. Pharmacol., 83, 586 (2012); Ding, J, et al.: J. Chrom B Anal. Technol. Biomed. Life Sci., 895, 108 (2012);

Fórmula: C₂₄H₁₅D₈N₅O

Cor e Forma: Neat

Peso molecular: 405.53

Ref: TR-A726153

Apatinib

CAS: 811803-05-1

Apatinib, also known as rivoceranib, is an inhibitor of the vascular endothelial growth factor receptor 2 (VEGFR2) tyrosine kinase. Apatinib targets VEGFR2 with its action and has proven to have strong anti-tumor effects in human cancers. In studies in mice, apatinib acted as an Inhibitor of VEGFR2 and played an antiangiogenic effect. Apatinib has been suggested for the treatment of ischemia-induced proliferative retinopathy and neovascular age-related macular degeneration.

Fórmula: C₂₄H₂₃N₅O

Pureza: Min. 95%

Cor e Forma: Powder

Peso molecular: 397.47 g/mol

Ref: 3D-BA175030