CAS 817204-32-3

Citosina, N-benzoil-2'-desoxi-2'-fluoro-2'-metil-, 3',5'-dibenzoato, (2'R)-

Descrição:

Citosina, N-benzoil-2'-desoxi-2'-fluoro-2'-metil-, 3',5'-dibenzoato, (2'R)- é um derivado de nucleosídeo sintético caracterizado pela presença de um grupo benzóico e duas funcionalidades de éster benzoato. Este composto apresenta um açúcar ribose modificado, especificamente uma configuração de 2′-desoxi-2′-fluoro-2′-metilo, que melhora sua estabilidade e bioatividade em comparação com nucleosídeos naturais. A estereoquímica (2′R) indica uma disposição espacial específica dos substituintes ao redor da parte açucarada, o que é crucial para sua interação com alvos biológicos. A presença de flúor na parte açucarada pode influenciar as propriedades farmacocinéticas do composto, potencialmente melhorando sua resistência a nucleases. Este composto pode exibir propriedades antivirais ou anticancerígenas, tornando-o de interesse na química medicinal e no desenvolvimento de medicamentos. Suas características estruturais únicas contribuem para suas potenciais aplicações em contextos terapêuticos, particularmente no design de análogos de nucleosídeos para o tratamento de várias doenças.

Fórmula: C₃₁H₂₆FN₃O₇

InChI: InChI=1S/C31H26FN3O7/c1-31(32)25(42-28(38)22-15-9-4-10-16-22)23(19-40-27(37)21-13-7-3-8-14-21)41-29(31)35-18-17-24(34-30(35)39)33-26(36)20-11-5-2-6-12-20/h2-18,23,25,29H,19H2,1H3,(H,33,34,36,39)/t23-,25-,29-,31-/m1/s1

Chave InChI: InChIKey=MXEQSUUFNWPUJH-RDWHIKKYSA-N

SMILES: C[C@]1(F)[C@@H](O[C@H](COC(=O)C2=CC=CC=C2)[C@H]1OC(=O)C3=CC=CC=C3)N4C(=O)N=C(NC(=O)C5=CC=CC=C5)C=C4

Sinónimos:

• ((2R,3R,4R,5R)-5-(benzamido-2-oxopyrimidin-1(2H)-yl)-2-(benzoyloxymethyl)-4-fluoro-4-methyltetrahydrofuran-3-yl
• (2'R)-N-Benzoyl-2'-deoxy-2'-fluoro-2'-methylcytidine 3',5'-dibenzoate
• (2R,3R,4R,5R)-5-(4-benzamido-2-oxopyrimidin-1(2H)-yl)-2-((benzoyloxy)methyl)-4-fluoro-4-methyltetrahydrofuran-3-yl benzoate
• (2R,3R,4R,5R)-5-4-benzamide-2-oxopyrimidin-1(2H)-yl)-2-((benzoyloxy)methyl)-4-fluoro-4-methyltetrahydrofuran-3-yl benzoate
• 2'-Deoxy-2'-Fluoro-2'-Methyl-N-(Phenylcarbonyl) Cytidine
• 3',5'-O-4-Tribenzoyl-2'-deoxy-2'-fluoro-2'-C-methylcytidine
• Cytidine, N-benzoyl-2′-deoxy-2′-fluoro-2′-methyl-, 3′,5′-dibenzoate, (2′R)-
• N-benzoyl-3,5-di-O-benzoyl-2-deoxy-2-fluoro-2-methylcytidine
• PSI-6130 derivative
• Sofosbuvir N-3
• [(2R,3R,4R,5R)-5-(4-benzamido-2-oxo-1,2-dihydropyrimidin-1-yl)-3-(benzoyloxy)-4-fluoro-4-methyloxolan-2-yl]methyl benzoate
• Cytidine,N-benzoyl-2'-deoxy-2'-fluoro-2'-methyl-,3',5'-dibenzoate,(2'R)
• Cytidine, N-Benzoyl-2'-Deoxy-2'-Fluoro-2'-Methyl-3',5'-Dibenzoate, (2'R)-
• Cytidine, N-benzoyl-2'-deoxy-2'-fluoro-2'-Methyl-, 3',5'-dibenzoate, (2'R)
• Sofosbuvir Intermediates1
• (2'R)-N-Benzoyl-2'-deoxy-2'-fluoro-2'-methylcytidine 3',5'-d
• Sofibute 12
• 2'-Defluro-2'-methylene Sofosbuvir
• Sofosbuvir INT 2
• Sofosbuvir Tri benzoyl fluoro cytidine
• N4,3',5'-tri-O-benzoyl-2'-deoxy-2'-fluoro-2'-C-Methylcytidine
• SF-3
• R)-N-benzoyl-2&rsquo
• PSI-6130 derivative ISO 9001：2015 REACH
• Sofosbuvir int. N-3
• -dibenzoateCytidine
• Sofosbuvir Intermediate 2
• InterMediate of Sofosbuir
• (2R,3R,4R,5R)-5-(4-benzaMido-2-oxopyriMidin-1(2H)-yl)
• (2'R)-N-Bz-2'-deoxy-2'-F-2'-Methylcytidine 3',5'-dibenzoate
• -methyl-3&rsquo
• N-BENZOYL-2'-DEOXY-2'-FLUORO-2METHYL-3'5'-DIBENZOATE(2R)
• (2'R)-N-Benzoyl-2'-deoxy-2'-fluoro-2'-methyl-3',5'-dibenzoate Cytidine
• 2'-Deoxy-2'-fluoro-2'- Methyl-N-(phenylcarbonyl) cytidine　(N-3)
• Sofosbuvir Impurity 69
• (2R,3R,4R,5R)-5-(4-Benzamido-2-oxopyrimidin-1(2H)-yl)-2-((benzoyloxy)methyl)-4-fluoro-4-methyltetrahydrofuran-3-yl benzoate(2R,3R,4R,5R)-5-(4-Benzamido-2-oxopyrimidin-1(2H)-yl)-2-((benzoyloxy)methyl)-4-fluoro-4-methyltetrahydrofuran-3-yl benzoate
• Sofosbuvir imp-5

Cytidine, N-benzoyl-2'-deoxy-2'-fluoro-2'-methyl-, 3',5'-dibenzoate,(2'R)-

CAS: 817204-32-3

Fórmula: C₃₁H₂₆FN₃O₇

Pureza: 97%

Cor e Forma: Solid

Peso molecular: 571.5524

Ref: IN-DA00ID7G

Sofosbuvir Impurity 56

CAS: 817204-32-3

Fórmula: C₃₁H₂₆FN₃O₇

Cor e Forma: White To Off-White Solid

Peso molecular: 571.56

Ref: 4Z-S-055063

(2R,3R,4R,5R)-5-(4-Benzamido-2-Oxopyrimidin-1(2H)-YL)-2-((Benzoyloxy)Methyl)-4-Fluoro-4-Methyltetrahydrofuran-3-YL Benzoate

CAS: 817204-32-3

(2R,3R,4R,5R)-5-(4-Benzamido-2-Oxopyrimidin-1(2H)-YL)-2-((Benzoyloxy)Methyl)-4-Fluoro-4-Methyltetrahydrofuran-3-YL Benzoate

Pureza: 98%

Peso molecular: 571.55g/mol

Ref: 54-PC104929

(2R,3R,4R,5R)-5-(4-benzamido-2-oxopyrimidin-1(2H)-yl)-2-((benzoyloxy)methyl)-4-fluoro-4-methyltetrahydrofuran-3-yl benzoate

CAS: 817204-32-3

Pureza: 97%

Peso molecular: 571.5609741210938

Ref: 10-F790039

Sofosbuvir Impurity 5

CAS: 817204-32-3

Fórmula: C₃₁H₂₆FN₃O₇

Peso molecular: 571.6

Ref: ST-EA-CP-S45027

(2'R)-N-Benzoyl-2'-deoxy-2'-fluoro-2'-methylcytidine 3',5'-d

CAS: 817204-32-3

(2'R)-N-Benzoyl-2'-deoxy-2'-fluoro-2'-methylcytidine 3',5'-diphosphate (2'R)-N-benzoyl-2'-deoxy-2'-fluoro-2'-methylcytidine 3',5'-diphosphate) is a modified nucleoside that is an antiviral, anticancer, and activator of DNA synthesis. It has been shown to be the first synthetic nucleotide analogue to have significant activity against HIV in vitro. The synthesis of this compound starts with the diphosphate or monophosphate form of cytidine. The phosphate group is removed and replaced with a 2'R benzoyl group. This process is followed by fluorination and methylation steps. Finally, the 5' hydroxyl group is cleaved to give 2'R -N benzoyl 2'-deoxy-2'-fluoro-2'-

Fórmula: C₃₁H₂₆FN₃O₇

Pureza: Min. 95%

Peso molecular: 571.55 g/mol

Ref: 3D-NB98842