CAS 82159-09-9

Epalrestat

Descrição:

Epalrestat é um composto farmacêutico usado principalmente como um inibidor da aldose redutase, que desempenha um papel significativo no manejo das complicações diabéticas, particularmente na neuropatia diabética. Seu mecanismo de ação envolve a inibição da enzima aldose redutase, que é responsável pela conversão de glicose em sorbitol, reduzindo assim o acúmulo de sorbitol e prevenindo o estresse osmótico e oxidativo nos tecidos nervosos. Epalrestat é caracterizado por sua relativamente baixa solubilidade em água, o que pode afetar sua biodisponibilidade. O composto é tipicamente administrado por via oral e tem sido estudado por seu potencial para melhorar a função nervosa e aliviar os sintomas associados à neuropatia diabética. Além disso, possui um perfil de segurança favorável, com efeitos colaterais geralmente leves e gerenciáveis. A eficácia e segurança de Epalrestat foram avaliadas em vários ensaios clínicos, contribuindo para sua aceitação em certas regiões para o tratamento de complicações diabéticas. No geral, Epalrestat representa uma abordagem direcionada no manejo do diabetes, focando em mitigar os efeitos a longo prazo da hiperglicemia na saúde nervosa.

Fórmula: C₁₅H₁₃NO₃S₂

InChI: InChI=1/C15H13NO3S2/c1-10(7-11-5-3-2-4-6-11)8-12-14(19)16(9-13(17)18)15(20)21-12/h2-8H,9H2,1H3,(H,17,18)/b10-7+,12-8+

Chave InChI: InChIKey=CHNUOJQWGUIOLD-NFZZJPOKSA-N

SMILES: C(\C(=C\C1=CC=CC=C1)\C)=C\2/C(=O)N(CC(O)=O)C(=S)S2

Sinónimos:

• (5Z)-5-[(2E)-2-Methyl-3-phenyl-2-propen-1-ylidene]-4-oxo-2-thioxo-3-thiazolidineacetic acid
• 2-[(Z)-5-((E)-2-Methyl-3-phenylallylidene)-4-oxo-2-thioxothiazolidin-3-yl]acetic acid
• 3-Thiazolidineacetic acid, 5-(2-methyl-3-phenyl-2-propenylidene)-4-oxo-2-thioxo-, (E,E)-
• 3-Thiazolidineacetic acid, 5-(2-methyl-3-phenyl-2-propenylidene)-4-oxo-2-thioxo-, (Z,E)-
• 3-Thiazolidineacetic acid, 5-[(2E)-2-methyl-3-phenyl-2-propen-1-ylidene]-4-oxo-2-thioxo-, (5Z)-
• 3-Thiazolidineacetic acid, 5-[(2E)-2-methyl-3-phenyl-2-propenylidene]-4-oxo-2-thioxo-, (5Z)-
• 5-((1Z,2E)-2-Methyl-3-phenylpropenylidene)-4-oxo-2-thioxo-3-thiazolidineacetic acid
• 5-((Z,E)-beta-Methylcinnamylidene)-4-oxo-2-thioxo-3-thiazolidineacetic acid
• Eabeth
• Epalrestat [INN]
• Epalrestatum
• Epalrestatum [Latin]
• Kinedak
• Ono 2235
• Sorbistat
• Unii-424Dv0807X
• {(5E)-5-[(2E)-2-methyl-3-phenylprop-2-en-1-ylidene]-4-oxo-2-thioxo-1,3-thiazolidin-3-yl}acetic acid
• {(5Z)-5-[(2E)-2-methyl-3-phenylprop-2-en-1-ylidene]-4-oxo-2-thioxo-1,3-thiazolidin-3-yl}acetic acid
• (E，E)-5-(2-Methyl-3-phenyl-2-propenylidene)-4-oxo-2-thioxo-3-thiazo-lidineaeetic acid
• Epalresta
• Quinedac
• 2-((E)-5-((E)-2-METHYL-3-PHENYLALLYLIDENE)-4-OXO-2-THIOXOTHIAZOLIDIN-3-YL)ACETIC ACID
• e)-(e
• 5-((1z,2e)-2-methyl-3-phenylpropenylidene)-4-oxo-2-thioxo-3-thiazolidineacet
• Epatrestat
• EPALRESTAT(KINEDAK)
• 5-[(1Z,2E)-2-METHYL-3-PHENYLPROPENYLIDENE]-4-OXO-2-THIOXO-3-THIAZOLIDINEACETICACID(EPALRESTAT)
• (e,e)-2-[5-(2-methyl-3-phenyl-prop-2-enylidene)-4-oxo-2-sulfanylidene-thiazo lidin-3-yl]acetic acid
• EPALRESTAT
• Epatat
• [5-[(1Z,2E)-2-Methyl-3-phenylallylidene]-4-oxo-2-thioxothiazolidin-3-yl]acetic acid
• OTAVA-BB BB7211260020
• 3-thiazolidineaceticacid,5-(2-methyl-3-phenyl-2-propenylidene)-4-oxo-2-thioxo
• 2-[(5Z)-5[(E)-3-PHENIL-2-METHYLPROP-2-ENYLIDENE]-4-OXO-2-THIOXO-3-THIAZOLIDINYL] ACETIC ACID
• He IpaneMa Division

2-[(5Z)-5-[(2E)-2-methyl-3-phenylprop-2-en-1-ylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]acetic acid

CAS: 82159-09-9

Fórmula: C₁₅H₁₃NO₃S₂

Pureza: 95%

Cor e Forma: Solid

Peso molecular: 319.3986

Ref: IN-DA0036GD

Epalrestat

CAS: 82159-09-9

Epalrestat (ONO2235), an aldose reductase inhibitor, helps manage diabetic neuropathy symptoms and slows disease progression.

Fórmula: C₁₅H₁₃NO₃S₂

Pureza: 99.2% - 99.54%

Cor e Forma: Deep Red Acicular Crystal

Peso molecular: 319.4

Ref: TM-T1458

Epalrestat

CAS: 82159-09-9

Fórmula: C₁₅H₁₃NO₃S₂

Cor e Forma: Dark Orange Solid

Peso molecular: 319.39

Ref: 4Z-E-601

Epalrestat

CAS: 82159-09-9

Epalrestat

Pureza: ≥98%

Peso molecular: 319.4g/mol

Ref: 54-BUP17810

Epalrestat

CAS: 82159-09-9

Fórmula: C₁₅H₁₃NO₃S₂

Peso molecular: 319.40

Ref: 7W-GP0850

Epalrestat

CAS: 82159-09-9

Fórmula: C₁₅H₁₃NO₃S₂

Pureza: >98.0%(T)(HPLC)

Cor e Forma: Light yellow to Amber to Dark green powder to crystal

Peso molecular: 319.39

Ref: 3B-E0906

Epalrestat RS

CAS: 82159-09-9

Cor e Forma: Yellow To Orange

Ref: 2K-1027800021

Epalrestat

Produto Controlado

CAS: 82159-09-9

Applications An aldose reductase inhibitor. It is used in treatment of diabetic neuropathy.
References Terashima, H., et al.: J. Pharmacol. Exp. Ther., 229, 226 (1983), Kikkawa, R., et al.: Diabetologia, 24, 290 (1983), Kojima, K., et al.: Jpn. J. Ophthalmol., 29, 99 (1985),

Fórmula: C₁₅H₁₃NO₃S₂

Cor e Forma: Neat

Peso molecular: 319.40

Ref: TR-E565300

Epalrestat - Bio-X ™

CAS: 82159-09-9

Epalrestat is a carboxylic acid derivative that is used for the treatment of diabetic neuropathy. This drug is an aldose reductase inhibitor and aims to reduce the accumulation of intracellular sorbitol. Studies in rats have shown this drug to improve morphological abnormalities of nerves.

Fórmula: C₁₅H₁₃NO₃S₂

Pureza: Min. 95%

Cor e Forma: Powder

Peso molecular: 319.4 g/mol

Ref: 3D-BE164412

Epalrestat

CAS: 82159-09-9

Aldose reductase inhibitor

Fórmula: C₁₅H₁₃NO₃S₂

Pureza: Min. 98 Area-%

Cor e Forma: Powder

Peso molecular: 319.4 g/mol

Ref: 3D-FE22700

Epalrestat

CAS: 82159-09-9

Fórmula: C₁₅H₁₃NO₃S₂

Pureza: 95%

Cor e Forma: Solid

Peso molecular: 319.39

Ref: 10-F036565

Epalrestat-d5

Produto Controlado

CAS: 82159-09-9

Applications Epalrestat-d5 is the labeled analogue of Epalrestat (E565300), an aldose reductase inhibitor. It is used in treatment of diabetic neuropathy.
References Terashima, H., et al.: J. Pharmacol. Exp. Ther., 229, 226 (1983); Kikkawa, R., et al.: Diabetologia, 24, 290 (1983); Kojima, K., et al.: Jpn. J. Ophthalmol., 29, 99 (1985)

Fórmula: C₁₅H₈D₅NO₃S₂

Cor e Forma: Neat

Peso molecular: 324.43

Ref: TR-E565302