CAS 84625-61-6

Itraconazol

Descrição:

Itraconazol é um agente antifúngico triazólico usado principalmente para tratar várias infecções fúngicas, incluindo aquelas causadas por dermatófitos, leveduras e certos bolores. Funciona inibindo a síntese de ergosterol, um componente essencial das membranas celulares fúngicas, interrompendo assim sua integridade e função. Itraconazol é caracterizado por sua relativamente baixa solubilidade em água, mas é mais solúvel em solventes orgânicos, o que influencia sua biodisponibilidade. O composto tem uma fórmula molecular de C35H38Cl2N8O4S e apresenta uma estrutura complexa que inclui um anel triazólico. É tipicamente administrado por via oral ou intravenosa, com sua farmacocinética influenciada por fatores como a ingestão de alimentos e os níveis de pH. Itraconazol é conhecido por seu amplo espectro de atividade contra vários fungos, mas também pode interagir com outros medicamentos devido aos seus efeitos sobre as enzimas hepáticas. Os efeitos colaterais comuns podem incluir distúrbios gastrointestinais, elevações das enzimas hepáticas e potenciais efeitos cardiovasculares, exigindo monitoramento durante o tratamento.

Fórmula: C₃₅H₃₈Cl₂N₈O₄

InChI: InChI=1/C35H38Cl2N8O4/c1-3-25(2)45-34(46)44(24-40-45)29-7-5-27(6-8-29)41-14-16-42(17-15-41)28-9-11-30(12-10-28)47-19-31-20-48-35(49-31,21-43-23-38-22-39-43)32-13-4-26(36)18-33(32)37/h4-13,18,22-25,31H,3,14-17,19-21H2,1-2H3/t25?,31-,35-/s2

Chave InChI: InChIKey=VHVPQPYKVGDNFY-WGEGMAFPNA-N

SMILES: C([C@]1(O[C@@H](COC2=CC=C(C=C2)N3CCN(CC3)C4=CC=C(C=C4)N5C(=O)N(C(CC)C)N=C5)CO1)C6=C(Cl)C=C(Cl)C=C6)N7C=NC=N7

Sinónimos:

• 2-Butan-2-Yl-4-[4-[4-[4-[[2-(2,4-Dichlorophenyl)-2-(1,2,4-Triazol-1-Yl Methyl)-1,3-Dioxolan-4-Yl]Methoxy]Phenyl]Piperazin-1-Yl]Phenyl]-1,2,4-Triazol-3-One
• 3H-1,2,4-Triazol-3-one, 4-[4-[4-[4-[[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-2,4-dihydro-2-(1-methylpropyl)-, rel-
• 3H-1,2,4-Triazol-3-one, 4-[4-[4-[4-[[2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-2,4-dihydro-2-(1-methylpropyl)-
• Candistat
• Canditral
• Cladosal 100
• Fungitraxx
• Itrac
• Itraconozole
• Itralek
• Itrizole
• Oriconazole
• Orungal
• Orungamin
• Pur 1900
• R 51211
• SUBA Itraconazole
• Sempera
• Spherazole CR
• Spherazole IR
• Sporal
• Sporamelt
• Sporanox
• Sporanox IV
• Sporonox
• Traconal
• Triasporin
• cis-Itraconazole
• rel-4-[4-[4-[4-[[(2R,4S)-2-(2,4-Dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-2,4-dihydro-2-(1-methylpropyl)-3H-1,2,4-triazol-3-one

Itraconazole, 98%

CAS: 84625-61-6

Itraconazole is a triazole antifungal agent. It is used to inhibit cytochrome P-450-dependent enzymes and ergosterol synthesis. It has been used against histoplasmosis, blastomycosis, cryptococcal meningitis, and aspergillosis. It?s different formulations are used to study Candida strains in murine

Fórmula: C₃₅H₃₈Cl₂N₈O₄

Pureza: 98%

Cor e Forma: White to cream, Powder or crystalline powder

Peso molecular: 705.64

Ref: 02-J66390

Itraconazole

CAS: 84625-61-6

Cor e Forma: Neat

Ref: 61-FOR0258.00

Itraconazole 2.0 mg/ml in Dimethyl Sulfoxide

CAS: 84625-61-6

Cor e Forma: Single Solution

Ref: 61-AMP0258.00-36

ITRACONAZOLE CRS

CAS: 84625-61-6

ITRACONAZOLE CRS

Fórmula: C₃₅H₃₈Cl₂N₈O₄

Cor e Forma: White. Powder.

Peso molecular: 705.6334

Ref: 41-I7000000

Itraconazole

CAS: 84625-61-6

Itraconazole

Fórmula: C₃₅H₃₈CI₂N₈O₄

Pureza: 99.7%

Cor e Forma: White To Off-White

Peso molecular: 900.11055

Ref: 47-1199

ITRACONAZOLE FOR SYSTEM SUITABILITY CRS

CAS: 84625-61-6

ITRACONAZOLE FOR SYSTEM SUITABILITY CRS

Ref: 41-Y0001100

Itraconazole

CAS: 84625-61-6

Nucleic acids and their salts, whether or not chemically defined; other heterocyclic compounds, nesoi

Fórmula: C₃₅H₃₈ClN₈O₄

Cor e Forma: White Powder

Peso molecular: 669.27045

Ref: 45-1354251

Itraconazole

CAS: 84625-61-6

Fórmula: C₃₅H₃₈Cl₂N₈O₄

Pureza: 98%

Cor e Forma: Solid

Peso molecular: 705.6334

Ref: IN-DA003R60

Itraconazole

CAS: 84625-61-6

Itraconazole (R51211) is a triazole antifungal agent that inhibits cytochrome P-450-dependent enzymes required for ERGOSTEROL synthesis.

Fórmula: C₃₅H₃₈Cl₂N₈O₄

Pureza: 98% - 99.90%

Cor e Forma: Off-White Crystalline Solid

Peso molecular: 705.63

Ref: TM-T1011

Itraconazole

CAS: 84625-61-6

Itraconazole

Pureza: ≥98%

Peso molecular: 705.63g/mol

Ref: 54-BUP15992

Itraconazole-d3

CAS: 84625-61-6

Fórmula: C₃₅H₃₅D₃Cl₂N₈O₄

Cor e Forma: Off-White Solid

Peso molecular: 708.67

Ref: 4Z-I-032

Itraconazole-d9

CAS: 84625-61-6

Fórmula: C₃₅H₂₉D₉Cl₂N₈O₄

Cor e Forma: Off-White Solid

Peso molecular: 714.70

Ref: 4Z-I-036

Itraconazole Impurity 5

CAS: 1217510-38-7, 84625-61-6

Fórmula: C₃₄H₃₅Cl₂N₈O₄·Cl

Cor e Forma: Yellow Solid

Peso molecular: 690.61 35.45

Ref: 4Z-I-0331

Itraconazole N-Oxide

CAS: 84625-61-6

Fórmula: C₃₅H₃₈Cl₂N₈O₅

Cor e Forma: White To Off-White Solid

Peso molecular: 721.64

Ref: 4Z-I-0329

Itraconazole

CAS: 84625-61-6

Fórmula: C₃₅H₃₈Cl₂N₈O₄

Pureza: 99.0 - 101.0 % (dried basis)

Cor e Forma: White or almost white powder

Peso molecular: 705.63

Ref: 7W-GA0307

Itraconazole

CAS: 84625-61-6

Fórmula: C₃₅H₃₈Cl₂N₈O₄

Cor e Forma: White To Off-White Solid

Peso molecular: 705.64

Ref: 4Z-I-031

Itraconazole

CAS: 84625-61-6

Itraconazole

Pureza: 98%

Peso molecular: 705.63g/mol

Ref: 54-OR1029174

Itraconazole

CAS: 84625-61-6

Cor e Forma: Neat

Ref: 86-MM0258.00

Itraconazole

Produto Controlado

CAS: 84625-61-6

Fórmula: C₃₅H₃₈Cl₂N₈O₄

Cor e Forma: Neat

Peso molecular: 705.63

Ref: 04-C14485000

Itraconazole

CAS: 84625-61-6

Fórmula: C₃₅H₃₈Cl₂N₈O₄

Pureza: >98.0%(T)(HPLC)

Cor e Forma: White to Almost white powder to crystal

Peso molecular: 705.64

Ref: 3B-I0732

Itraconazole-d9

Produto Controlado

CAS: 84625-61-6

Applications Itraconazole-d9, is the labeled analogue of Itraconazole (I937500, an orally active antimycotic structurally related to Ketoconazole. Antifungal. It is a COVID19-related research product.
References Espinel-Ingroff, A., et al.: Antimicrob. Agents Chemother., 26, 5 (1984), Heykants, J., et al.: Mycoses, 32, Suppl 1, 67 (1989), Sugar, A.M., et al.: Curr. Clin. Top. Infect. Dis., 13, 74 (1993),

Fórmula: C₃₅H₂₉D₉Cl₂N₈O₄

Cor e Forma: Off-White To Beige

Peso molecular: 714.69

Ref: TR-I937504

Itraconazole

Produto Controlado

CAS: 84625-61-6

Applications Itraconazole is an orally active antimycotic structurally related to Ketoconazole. Antifungal. It is a COVID19-related research product.
References Espinel-Ingroff, A., et al.: Antimicrob. Agents Chemother., 26, 5 (1984); Heykants, J., et al.: Mycoses, 32, Suppl 1, 67 (1989); Sugar, A.M.,et al.: Curr. Clin. Top. Infect. Dis., 13, 74 (1993);

Fórmula: C₃₅H₃₈Cl₂N₈O₄

Cor e Forma: White To Off-White

Peso molecular: 705.63

Ref: TR-I937500

Itraconazole - Bio-X ™

CAS: 84625-61-6

Itraconazole is an anti-fungal drug that inhibits the synthesis of ergosterol, a component of the fungal cell membrane. Itraconazole is in a class of antifungals called triazoles. The drug binds to ergosterol in the fungal cell membrane and prevents it from being inserted into the membrane. This decreases the permeability of the plasma membrane, causing leakage of cellular contents. Additionally, it has been shown to have a glucose-lowering effect in the treatment of acute leukaemia and may be used for research in aiding to diagnose hematopoietic stem cell or leukaemia.

Fórmula: C₃₅H₃₈Cl₂N₈O₄

Pureza: Min. 98 Area-%

Cor e Forma: Powder

Peso molecular: 705.63 g/mol

Ref: 3D-BI164594

Itraconazole

CAS: 84625-61-6

Itraconazole is an anti-fungal drug that inhibits the synthesis of ergosterol, a component of the fungal cell membrane. It also has been shown to have a glucose-lowering effect in the treatment of acute leukemia and may be used to diagnose hematopoietic stem cell or leukemia. Itraconazole is available as an oral tablet and can be administered for primary care in patients with wild-type strains of Aspergillus fumigatus, Candida albicans, Cryptococcus neoformans, Histoplasma capsulatum, and Trichophyton mentagrophytes. The drug binds to ergosterol in the fungal cell membrane and prevents it from being inserted into the membrane. This decreases the permeability of the plasma membrane, causing leakage of cellular contents.

Fórmula: C₃₅H₃₈Cl₂N₈O₄

Pureza: Min. 98.5 Area-%

Cor e Forma: White Powder

Peso molecular: 705.63 g/mol

Ref: 3D-FB24741