CAS 84625-61-6
:Itraconazol
Descrição:
Itraconazol é um agente antifúngico triazólico usado principalmente para tratar várias infecções fúngicas, incluindo aquelas causadas por dermatófitos, leveduras e certos bolores. Funciona inibindo a síntese de ergosterol, um componente essencial das membranas celulares fúngicas, interrompendo assim sua integridade e função. Itraconazol é caracterizado por sua relativamente baixa solubilidade em água, mas é mais solúvel em solventes orgânicos, o que influencia sua biodisponibilidade. O composto tem uma fórmula molecular de C35H38Cl2N8O4S e apresenta uma estrutura complexa que inclui um anel triazólico. É tipicamente administrado por via oral ou intravenosa, com sua farmacocinética influenciada por fatores como a ingestão de alimentos e os níveis de pH. Itraconazol é conhecido por seu amplo espectro de atividade contra vários fungos, mas também pode interagir com outros medicamentos devido aos seus efeitos sobre as enzimas hepáticas. Os efeitos colaterais comuns podem incluir distúrbios gastrointestinais, elevações das enzimas hepáticas e potenciais efeitos cardiovasculares, exigindo monitoramento durante o tratamento.
Fórmula:C35H38Cl2N8O4
InChI:InChI=1/C35H38Cl2N8O4/c1-3-25(2)45-34(46)44(24-40-45)29-7-5-27(6-8-29)41-14-16-42(17-15-41)28-9-11-30(12-10-28)47-19-31-20-48-35(49-31,21-43-23-38-22-39-43)32-13-4-26(36)18-33(32)37/h4-13,18,22-25,31H,3,14-17,19-21H2,1-2H3/t25?,31-,35-/s2
Chave InChI:InChIKey=VHVPQPYKVGDNFY-WGEGMAFPNA-N
SMILES:C([C@]1(O[C@@H](COC2=CC=C(C=C2)N3CCN(CC3)C4=CC=C(C=C4)N5C(=O)N(C(CC)C)N=C5)CO1)C6=C(Cl)C=C(Cl)C=C6)N7C=NC=N7
Sinónimos:- 2-Butan-2-Yl-4-[4-[4-[4-[[2-(2,4-Dichlorophenyl)-2-(1,2,4-Triazol-1-Yl Methyl)-1,3-Dioxolan-4-Yl]Methoxy]Phenyl]Piperazin-1-Yl]Phenyl]-1,2,4-Triazol-3-One
- 3H-1,2,4-Triazol-3-one, 4-[4-[4-[4-[[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-2,4-dihydro-2-(1-methylpropyl)-, rel-
- 3H-1,2,4-Triazol-3-one, 4-[4-[4-[4-[[2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-2,4-dihydro-2-(1-methylpropyl)-
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- Orungal
- Orungamin
- Pur 1900
- R 51211
- SUBA Itraconazole
- Sempera
- Spherazole CR
- Spherazole IR
- Sporal
- Sporamelt
- Sporanox
- Sporanox IV
- Sporonox
- Traconal
- Triasporin
- cis-Itraconazole
- rel-4-[4-[4-[4-[[(2R,4S)-2-(2,4-Dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-2,4-dihydro-2-(1-methylpropyl)-3H-1,2,4-triazol-3-one
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Foram encontrados 25 produtos.
Itraconazole, 98%
CAS:Itraconazole is a triazole antifungal agent. It is used to inhibit cytochrome P-450-dependent enzymes and ergosterol synthesis. It has been used against histoplasmosis, blastomycosis, cryptococcal meningitis, and aspergillosis. It?s different formulations are used to study Candida strains in murineFórmula:C35H38Cl2N8O4Pureza:98%Cor e Forma:White to cream, Powder or crystalline powderPeso molecular:705.64ITRACONAZOLE CRS
CAS:ITRACONAZOLE CRSFórmula:C35H38Cl2N8O4Cor e Forma:White. Powder.Peso molecular:705.6334Itraconazole
CAS:ItraconazoleFórmula:C35H38CI2N8O4Pureza:99.7%Cor e Forma:White. To. Off-WhitePeso molecular:900.11055Itraconazole
CAS:Nucleic acids and their salts, whether or not chemically defined; other heterocyclic compounds, nesoiFórmula:C35H38ClN8O4Cor e Forma:White PowderPeso molecular:669.27045Ref: IN-DA003R60
25mg20,00€100mg23,00€1g25,00€250mg25,00€5g49,00€10g64,00€25g112,00€50g197,00€100g250,00€500g534,00€250g678,00€1kg709,00€5kg3.396,00€Itraconazole
CAS:Itraconazole (R51211) is a triazole antifungal agent that inhibits cytochrome P-450-dependent enzymes required for ERGOSTEROL synthesis.Fórmula:C35H38Cl2N8O4Pureza:98% - 99.90%Cor e Forma:SolidPeso molecular:705.63Itraconazole
CAS:Fórmula:C35H38Cl2N8O4Pureza:99.0 - 101.0 % (dried basis)Cor e Forma:White or almost white powderPeso molecular:705.63Itraconazole N-Oxide
CAS:Fórmula:C35H38Cl2N8O5Cor e Forma:White To Off-White SolidPeso molecular:721.64Itraconazole Impurity 5
CAS:Fórmula:C34H35Cl2N8O4·ClCor e Forma:Yellow SolidPeso molecular:690.61 35.45Itraconazole
CAS:Fórmula:C35H38Cl2N8O4Pureza:>98.0%(T)(HPLC)Cor e Forma:White to Almost white powder to crystalPeso molecular:705.64Itraconazole
CAS:Produto ControladoApplications Itraconazole is an orally active antimycotic structurally related to Ketoconazole. Antifungal. It is a COVID19-related research product.
References Espinel-Ingroff, A., et al.: Antimicrob. Agents Chemother., 26, 5 (1984); Heykants, J., et al.: Mycoses, 32, Suppl 1, 67 (1989); Sugar, A.M.,et al.: Curr. Clin. Top. Infect. Dis., 13, 74 (1993);Fórmula:C35H38Cl2N8O4Cor e Forma:NeatPeso molecular:705.63Itraconazole-d9
CAS:Produto ControladoApplications Itraconazole-d9, is the labeled analogue of Itraconazole (I937500, an orally active antimycotic structurally related to Ketoconazole. Antifungal. It is a COVID19-related research product.
References Espinel-Ingroff, A., et al.: Antimicrob. Agents Chemother., 26, 5 (1984), Heykants, J., et al.: Mycoses, 32, Suppl 1, 67 (1989), Sugar, A.M., et al.: Curr. Clin. Top. Infect. Dis., 13, 74 (1993),Fórmula:C35H29D9Cl2N8O4Cor e Forma:NeatPeso molecular:714.69Itraconazole - Bio-X ™
CAS:Itraconazole is an anti-fungal drug that inhibits the synthesis of ergosterol, a component of the fungal cell membrane. Itraconazole is in a class of antifungals called triazoles. The drug binds to ergosterol in the fungal cell membrane and prevents it from being inserted into the membrane. This decreases the permeability of the plasma membrane, causing leakage of cellular contents. Additionally, it has been shown to have a glucose-lowering effect in the treatment of acute leukaemia and may be used for research in aiding to diagnose hematopoietic stem cell or leukaemia.Fórmula:C35H38Cl2N8O4Pureza:Min. 98 Area-%Cor e Forma:PowderPeso molecular:705.63 g/molItraconazole
CAS:Itraconazole is an anti-fungal drug that inhibits the synthesis of ergosterol, a component of the fungal cell membrane. It also has been shown to have a glucose-lowering effect in the treatment of acute leukemia and may be used to diagnose hematopoietic stem cell or leukemia. Itraconazole is available as an oral tablet and can be administered for primary care in patients with wild-type strains of Aspergillus fumigatus, Candida albicans, Cryptococcus neoformans, Histoplasma capsulatum, and Trichophyton mentagrophytes. The drug binds to ergosterol in the fungal cell membrane and prevents it from being inserted into the membrane. This decreases the permeability of the plasma membrane, causing leakage of cellular contents.Fórmula:C35H38Cl2N8O4Pureza:Min. 98.5 Area-%Cor e Forma:White PowderPeso molecular:705.63 g/mol
