CAS 85-61-0

Coenzima A

Descrição:

Coenzima A (CoA) é um cofator vital em várias reações bioquímicas, principalmente envolvido no metabolismo de ácidos graxos e carboidratos. É uma molécula complexa composta de adenosina, ácido pantotênico (vitamina B5) e um grupo mercaptoetilamina. CoA desempenha um papel crucial na formação de acetil-CoA, que é um substrato chave para o ciclo do ácido cítrico, facilitando a produção de energia nas células. A substância é caracterizada por sua capacidade de formar ligações tioéster, que são essenciais para a ativação de grupos acilo em vias metabólicas. Coenzima A é solúvel em água e exibe um alto grau de reatividade devido à presença de seu grupo tiol, permitindo que participe de várias reações enzimáticas. Sua estrutura permite que atue como transportador de grupos acilo, tornando-o indispensável na síntese e degradação de ácidos graxos e no metabolismo de aminoácidos. No geral, Coenzima A é integral ao metabolismo energético celular e à síntese de biomoléculas importantes.

Fórmula: C₂₁H₃₆N₇O₁₆P₃S

InChI: InChI=1S/C21H36N7O16P3S/c1-21(2,16(31)19(32)24-4-3-12(29)23-5-6-48)8-41-47(38,39)44-46(36,37)40-7-11-15(43-45(33,34)35)14(30)20(42-11)28-10-27-13-17(22)25-9-26-18(13)28/h9-11,14-16,20,30-31,48H,3-8H2,1-2H3,(H,23,29)(H,24,32)(H,36,37)(H,38,39)(H2,22,25,26)(H2,33,34,35)/t11-,14-,15-,16+,20-/m1/s1

Chave InChI: InChIKey=RGJOEKWQDUBAIZ-IBOSZNHHSA-N

SMILES: O[C@H]1[C@H](N2C=3C(N=C2)=C(N)N=CN3)O[C@H](COP(OP(OCC([C@H](C(NCCC(NCCS)=O)=O)O)(C)C)(=O)O)(=O)O)[C@H]1OP(=O)(O)O

Sinónimos:

• <span class="text-smallcaps">D</span>-Coenzyme A
• Adenosine 5'-(trihydrogen diphosphate) 3'-(dihydrogen phosphate) P'-[(R)-3-hydroxy-4-[[3-[(2-mercaptoethyl)amino]-3-oxopropyl]amino]-2,2-dimethyl-4-oxobutyl] ester
• Adenosine 5'-(trihydrogen diphosphate), 3'-(dihydrogen phosphate), P'-[3-hydroxy-4-[[3-[(2-mercaptoethyl)amino]-3-oxopropyl]amino]-2,2-dimethyl-4-oxobutyl] ester, (R)-
• Aluzime
• COA
• CoASH
• Coa-Sh
• Coalip
• Coenzym A
• Coenzyme A Free Acid From Yeast
• Coenzyme A Hydrate
• Coenzyme A, free acid, lyophilized, 75%
• Coenzyme A, free acid, lyophilized, min. 75% (enzym.)
• Coenzyme ASH
• Coenzyme a, free acid
• D-Coenzyme A
• Lucina
• Reduced CoA
• Thiol-CoA
• [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]methyl (3R)-3-hydroxy-2,2-dimethyl-4-oxo-4-({3-oxo-3-[(2-sulfanylethyl)amino]propyl}amino)butyl dihydrogen diphosphate (non-preferred name)
• [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]methyl (3S)-3-hydroxy-2,2-dimethyl-4-oxo-4-({3-oxo-3-[(2-sulfanylethyl)amino]propyl}amino)butyl dihydrogen diphosphate (non-preferred name)
• [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]methyl 3-hydroxy-2,2-dimethyl-4-oxo-4-({3-oxo-3-[(2-sulfanylethyl)amino]propyl}amino)butyl dihydrogen diphosphate (non-preferred name)
• coenzima A

Coenzyme A

CAS: 85-61-0

Coenzyme A

Pureza: ≥90%

Peso molecular: 767.53g/mol

Ref: 54-BUP15611

Coenzyme A Free Acid

CAS: 85-61-0

Coenzyme A Free Acid

Fórmula: C₂₁H₃₆N₇O₁₆P₃S

Pureza: ≥95.0%

Peso molecular: 767.53g/mol

Ref: 54-BIA0812

Coenzyme A hydrate

CAS: 85-61-0

Fórmula: C₂₁H₃₆N₇O₁₆P₃S·xH₂O

Pureza: ≥ 90.0%

Cor e Forma: White to off-white or pale yellow powder

Peso molecular: 767.53 (anhydrous)

Ref: 7W-GK0114

Coenzyme A

CAS: 85-61-0

Coenzyme A is an obligatory cofactor in all living cells synthesized from pantothenate (Vitamin B5), adenosine triphosphate (ATP), and cysteine.

Fórmula: C₂₁H₃₆N₇O₁₆P₃S

Pureza: 93.84%

Cor e Forma: Solid

Peso molecular: 767.53

Ref: TM-T10857

Coenzyme A free acid

CAS: 85-61-0

Fórmula: C21H36N7O16P3S

Pureza: >94%

Cor e Forma: Solid

Peso molecular: 767.54

Ref: 48-19-1001

Coenzyme A hydrate

CAS: 85-61-0

Coenzyme A hydrate is essential in the metabolism of fatty acids and the synthesis of acetyl-CoA. It is also employed in pharmaceutical applications, especially in drug development and formulation. Its distinctive properties improve drug solubility and bioavailability, making it an essential component in the creation of therapeutic agents.

Fórmula: C₂₁H₃₆N₇O₁₆P₃S·xH₂O

Pureza: (Enzymatic) Min. 75%

Cor e Forma: White Off-White Slightly Yellow Powder

Peso molecular: 767.54 g/mol

Ref: 3D-NC45965

Coenzyme A Free Acid extrapure, 90%

CAS: 85-61-0

Fórmula: C₂₁H₃₆N₇O₁₆P₃S

Pureza: min. 90%

Cor e Forma: Almost white to slightly yellowish, Lyophilized powder

Peso molecular: 767.54

Ref: SR-40804

Coenzyme A, Free Acid

CAS: 85-61-0

Pureza: 95%

Peso molecular: 767.115

Ref: 10-C300023

Coenzyme A S-Pyrazinecarboxylate Trisodium Salt

Produto Controlado

CAS: 85-61-0

Applications Coenzyme A S-Pyrazinecarboxylate is a derivative of Coenzyme A (C636400); a cofactor in enzymatic acetyl transfer reactions. It is the source of the phosphopantetheine group that is added as a prosthetic group to proteins such as acyl carrier protein and formyltetrahydrofolate dehydrogenase.
References Strickland K.C. et al.: J. Biol. Chem., 285, 1627 (2010); Elovson J. et al.: J. Biol. Chem., 243, 3603 (1968)

Fórmula: C₂₆H₃₅N₉Na₃O₁₇P₃S

Cor e Forma: Neat

Peso molecular: 939.56

Ref: TR-C636415