CAS 850140-72-6

Afatinib

Descrição:

Afatinib é um inibidor de tirosina quinase de pequenas moléculas usado principalmente no tratamento do câncer de pulmão de células não pequenas (CPNPC) que apresenta mutações específicas no gene do receptor do fator de crescimento epidérmico (EGFR). É caracterizado por sua capacidade de se ligar irreversivelmente ao EGFR e a outros membros da família de receptores ErbB, inibindo assim suas vias de sinalização que promovem a proliferação e sobrevivência celular. A fórmula química de Afatinib é C24H25ClFN5O3, e apresenta uma estrutura complexa que inclui um anel fenílico substituído por cloro e um moiety de piperazina. Afatinib é administrado por via oral e é conhecido por seus potenciais efeitos colaterais, que podem incluir diarreia, erupção cutânea e estomatite. Sua farmacocinética indica que tem uma meia-vida relativamente longa, permitindo a dosagem uma vez ao dia. O medicamento é classificado como um agente antineoplásico e faz parte da terapia direcionada, representando um avanço significativo na medicina personalizada para pacientes com perfis genéticos específicos em seus tumores.

Fórmula: C₂₄H₂₅ClFN₅O₃

InChI: InChI=1/C24H25ClFN5O3/c1-31(2)8-3-4-23(32)30-21-11-17-20(12-22(21)34-16-7-9-33-13-16)27-14-28-24(17)29-15-5-6-19(26)18(25)10-15/h3-6,10-12,14,16H,7-9,13H2,1-2H3,(H,30,32)(H,27,28,29)/b4-3+

Chave InChI: InChIKey=ULXXDDBFHOBEHA-CWDCEQMOSA-N

SMILES: N(C=1C2=C(C=C(O[C@H]3CCOC3)C(NC(/C=C/CN(C)C)=O)=C2)N=CN1)C4=CC(Cl)=C(F)C=C4

Sinónimos:

• (2E)-N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-2-butenamide
• (2E)-N-{4-[(3-chloro-4-fluorophenyl)amino]-7-(tetrahydrofuran-3-yloxy)quinazolin-6-yl}-4-(dimethylamino)but-2-enamide
• (E)-N-(7-((S)-tetrahydrofuran-3-yloxy)-4-(3-chloro-4-fluorophenylamino)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide
• (S,E)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-dime
• 2-Butenamide, N-(4-((3-chloro-4-fluorophenyl)amino)-7-(((3S)-tetrahydro-3-furanyl)oxy)-6-quinazolinyl)-4-(dimethylamino)-
• 2-Butenamide, N-[4-[(3-chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-, (2E)-
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Afatinib

CAS: 850140-72-6

Fórmula: C₂₄H₂₅ClFN₅O₃

Pureza: >97.0%(HPLC)(N)

Cor e Forma: White to Orange to Green powder to crystal

Peso molecular: 485.94

Ref: 3B-A2870

Afatinib (BIBW 2992)

CAS: 850140-72-6

Fórmula: C₂₄H₂₅ClFN₅O₃

Cor e Forma: White To Off-White Solid

Peso molecular: 485.95

Ref: 4Z-A-111001

Afatinib

CAS: 850140-72-6

Afatinib

Pureza: ≥95%

Peso molecular: 485.94g/mol

Ref: 54-BUP15589

Afatinib

CAS: 850140-72-6

Afatinib (BIBW 2992) is an irreversible and orally EGFR family inhibitor that inhibits EGFR and HER2. Afatinib has antitumor activity. Cost effective and quality assured.

Fórmula: C₂₄H₂₅ClFN₅O₃

Pureza: 98.56% - 99.9%

Cor e Forma: Off-White Solid

Peso molecular: 485.94

Ref: TM-T21312

Afatinib-d4

CAS: 850140-72-6

Fórmula: C₂₄H₂₁ClFN₅O₃D₄

Peso molecular: 489.97

Ref: 4Z-A-111002

Afatinib

CAS: 850140-72-6

Afatinib

Fórmula: C₂₄H₂₅ClFN₅O₃

Pureza: By hplc: >99% (Typical Value in Batch COA)

Cor e Forma: white to off-white solid

Peso molecular: 485.94g/mol

Ref: 54-BIFK0010

Afatinib, Free Base

CAS: 850140-72-6

Pureza: 99.0%

Cor e Forma: Solid, No data available.

Peso molecular: 485.94000244140625

Ref: 10-F050665

Afatinib

CAS: 850140-72-6

Applications An aminocrotonylamino-substituted quinazoline derivative used for treating cancer and diseases of the respiratory tract, lungs, gastrointestinal tract, bile duct, and gallbladder.
References Nakao, K., et al.: Sci. Rep., 9, 18202 92019); Ebert, K, PLoS One, 14, 0223225 (2019)

Fórmula: C₂₄H₂₅ClFN₅O₃

Cor e Forma: Neat

Peso molecular: 485.94

Ref: TR-A355300

Afatinib - Bio-X ™

CAS: 850140-72-6

Afatinib is a small molecule that inhibits the activity of cellular kinases that are involved in the progression of cancer. It is an Irreversible inhibitor of three members of the ErbB family. This molecule binds covalently to cysteine 797 residue in HER2 and blocks downstream cellular signalling which inhibits cellular growth and promotes apoptosis. It has been researched for the treatment of non-small cell lung cancer (NSCLC), breast cancer, pancreatic cancer and colorectal cancer.

Fórmula: C₂₄H₂₅ClFN₅O₃

Pureza: Min. 95%

Cor e Forma: Powder

Peso molecular: 485.94 g/mol

Ref: 3D-BA164141

Afatinib-d4

Produto Controlado

CAS: 850140-72-6

Fórmula: C₂₄D₄H₂₁ClFN₅O₃

Cor e Forma: Neat

Peso molecular: 489.963

Ref: TR-A355302

Afatinib

CAS: 850140-72-6

Irreversible blocker of three members of the ErbB family (ErbB1, ErbB2/HER2, and ErbB4) with IC50 in nanomolar range. The compound binds covalently to cysteine 797 residue in HER2 and blocks downstream cellular signalling, inhibits cellular growth and promotes apoptosis. Afatinib has been used for the treatment of tyrosine kinase inhibitor-resistant tumours with mutations in ErbB genes, especially for deletions in exon 19 and single nucleotide substitutions in exon 21. It has been used for treatment of non-small cell lung cancer (NSCLC), breast cancer, pancreatic cancer, colorectal cancer, etc.

Fórmula: C₂₄H₂₅ClFN₅O₃

Pureza: Min. 98 Area-%

Cor e Forma: Powder

Peso molecular: 485.94 g/mol

Ref: 3D-FC17230