CAS 850141-19-4

Darunavir Impurity 22

CAS: 850141-19-4

Fórmula: C₂₇H₃₇N₃O₇S

Cor e Forma: White To Off-White Solid

Peso molecular: 547.67

Ref: 4Z-D-3744

2-epi-Darunavir

CAS: 850141-19-4

Applications 2-epi-Darunavir is a stereoisomer to Darunavir (D193500), a second generation HIV-1-protease inhibitor; structurally similar to amprenavir. Antiviral. It is a COVID19-related research product.
References Rao, R.N., et. al.: J. Sep. Sci., 35, 2671 (2012); Koh, Y., et al.: Antimicrob. Agents Chemother., 47, 3123 (2003); Arasteh, K., et al.: AIDS, 19, 943 (2005); Surleraux, D.L.N.G., et al.: J. Med. Chem., 48, 1813 (2005)

Fórmula: C₂₇H₃₇N₃O₇S

Cor e Forma: Neat

Peso molecular: 547.66

Ref: TR-D193530

2-Epi-Darunavir

CAS: 850141-19-4

Fórmula: C₂₇H₃₇N₃O₇S

Peso molecular: 547.67

Ref: ST-EA-CP-D70048

2-Epi-darunavir

CAS: 850141-19-4

2-Epi-darunavir is a peptide that acts as an activator of the HIV-1 protease. It has been shown to be a potent inhibitor of HIV-1 protease, with IC50 values in the low nanomolar range. The 2-Epi-darunavir peptide binds to the active site of HIV-1 protease, blocking access by other molecules and preventing cleavage at the P1' position on the substrate. This results in a conformational change that prevents its interaction with the binding site on HIV-1 gp41. The 2-Epi darunavir peptide also inhibits protein interactions with ion channels and receptor proteins, which may inhibit cellular processes such as cell proliferation and apoptosis.

Fórmula: C₂₇H₃₇N₃O₇S

Pureza: Min. 95%

Peso molecular: 547.7 g/mol

Ref: 3D-AJB14119