CAS 850876-88-9

Danoprevir

Descrição:

Danoprevir é um medicamento antiviral utilizado principalmente no tratamento de infecções pelo vírus da hepatite C (VHC). Pertence à classe de medicamentos conhecidos como inibidores da protease, que atuam inibindo a enzima protease viral, impedindo assim a replicação do vírus. Danoprevir é caracterizado por sua estrutura química específica, que inclui uma série de grupos funcionais que contribuem para sua atividade e solubilidade. O composto é tipicamente administrado em combinação com outros agentes antivirais para aumentar sua eficácia e reduzir o potencial de resistência viral. Danoprevir mostrou um perfil farmacocinético favorável, com boa biodisponibilidade oral e uma meia-vida relativamente longa, permitindo esquemas de dosagem convenientes. Seu perfil de segurança inclui efeitos colaterais comuns associados a terapias antivirais, como fadiga, náuseas e possíveis elevações das enzimas hepáticas. No geral, Danoprevir representa um avanço significativo no tratamento da hepatite C crônica, particularmente em genótipos específicos do vírus.

Fórmula: C₃₅H₄₆FN₅O₉S

InChI: InChI=1S/C35H46FN5O9S/c1-34(2,3)50-32(45)37-27-13-8-6-4-5-7-11-22-17-35(22,31(44)39-51(47,48)24-14-15-24)38-29(42)28-16-23(19-41(28)30(27)43)49-33(46)40-18-21-10-9-12-26(36)25(21)20-40/h7,9-12,22-24,27-28H,4-6,8,13-20H2,1-3H3,(H,37,45)(H,38,42)(H,39,44)/b11-7-/t22-,23-,27+,28+,35-/m1/s1

Chave InChI: InChIKey=ZVTDLPBHTSMEJZ-JSZLBQEHSA-N

SMILES: C(NS(=O)(=O)C1CC1)(=O)[C@]23[C@@](C2)(/C=C\CCCCC[C@H](NC(OC(C)(C)C)=O)C(=O)N4[C@](C(=O)N3)(C[C@@H](OC(=O)N5CC=6C(C5)=C(F)C=CC6)C4)[H])[H]

Sinónimos:

• Danoprevir
• CS-64
• Itmn-191(Danoprevir)
• 4-Fluoro-1,3-dihydro-2H-isoindole-2-carboxylic acid (2R,6S,13aS,14aR,16aS)-14a-[[(cyclopropylsulfonyl)amino]carbonyl]-6-[[(1,1-dimethylethoxy)carbonyl]amino]-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydro-5,16-dioxocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin-2-yl ester
• ITMN 191
• R 7227
• 2H-Isoindole-2-carboxylic acid, 4-fluoro-1,3-dihydro-, (2R,6S,13aS,14aR,16aS)-14a-[[(cyclopropylsulfonyl)amino]carbonyl]-6-[[(1,1-dimethylethoxy)carbonyl]amino]-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydro-5,16-dioxocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin-2-yl ester
• 2H-Isoindole-2-carboxylic acid, 4-fluoro-1,3-dihydro-, (2R,6S,13aS,14aR,16aS)-14a-[[(cyclopropylsulfonyl)amino]carbonyl]-6-[[(1,1-dimethylethoxy)carbonyl]amino]-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydro-5,16-dio
• Itmn-191
• ITMN-191
• Intermune ITMN-191
• Danpprevir
• RG7227, ITMN-191, RO5190591
• Danoprevir(ITMN-191, RG7227)
• Danoprevir - ITMN 191 | RG 7227 | R 7227
• dimethylethoxy)carbonyl]amino]-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydro-5,16-dioxocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin-2-yl ester Danoprevir (ITMN-191)
• R7227
• RG72277
• Danoprevir(ITMN-191)
• (2R,6S,13aS,14aR,16aS,)-6-((tert-Butoxycarbonyl)amino)-14a-((cyclopropylsulfonyl)carbamoyl)-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin-2-yl 4-fluoroisoindoline-2-carboxylate
• RG7227
• ITMN-191; R7227; RO5190591; RG7227;ITMN191;ITMN 191
• Danoprevir (RG7227)
• Intepirdine
• (2R,6S,13aS,14aR,16aS,E)-6-((tert-butoxycarbonyl)aMino)-14a-((cyclopropylsulfonyl)carbaMoyl)-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin-2-yl 4-fluoroisoindoline-2-carboxylate
• (2R,6S,13aS,14aR,16aS,Z)-6-((tert-butoxycarbonyl)amino)-14a-((cyclopropylsulfonyl)carbamoyl)-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin-2-yl 4-fluoroisoindoline-2-carboxylate
• Danoprevir, >=98%

RG7227, ITMN-191, RO5190591

CAS: 850876-88-9

Fórmula: C₃₅H₄₆FN₅O₉S

Pureza: 99%

Cor e Forma: Solid

Peso molecular: 731.8312

Ref: IN-DA00G3O6

Danoprevir

CAS: 850876-88-9

Danoprevir

Pureza: ≥98%

Peso molecular: 731.83g/mol

Ref: 54-BUP04844

Danoprevir

CAS: 850876-88-9

Danoprevir (RG7227) is a peptidomimetic inhibitor of the NS3/4A protease(IC50=0.2-3.5 nM) of hepatitis C virus (HCV).

Fórmula: C₃₅H₄₆FN₅O₉S

Pureza: 98% - 99.80%

Cor e Forma: Solid

Peso molecular: 731.83

Ref: TM-T6025

Danoprevir

Produto Controlado

CAS: 850876-88-9

Applications Danoprevir is a selective and potent inhibitor of Hepatitis C virus.
References Ali, A. et al.: ACS. Chem. Biol., 8, 1469 (2013); Rong, L. et al.: PLoS. Comp. Biol., 9, e1002959 (2013);

Fórmula: C₃₅H₄₆FN₅O₉S

Cor e Forma: Neat

Peso molecular: 731.83

Ref: TR-D172820

Danoprevir

CAS: 850876-88-9

Danoprevir is an inhibitor of the viral protease. It is used in combination with other antiviral drugs for the treatment of hepatitis C virus (HCV) infections. Danoprevir has been shown to inhibit a number of resistant mutants, including protease-resistant mutants, which may have contributed to its effectiveness against HCV. The drug inhibits the activity of other enzymes, such as HIV-1 protease and influenza virus NS1 proteinase. Danoprevir has also been shown to be effective against HCV infection in animal models.

Fórmula: C₃₅H₄₆FN₅O₉S

Pureza: Min. 95%

Cor e Forma: White Powder

Peso molecular: 731.83 g/mol

Ref: 3D-FD106410