CAS 851199-59-2

Linaclotida

Descrição:

Linaclotida é um peptídeo sintético usado principalmente como medicamento para o tratamento da síndrome do intestino irritável com constipação (SII-C) e constipação idiopática crônica (CIC). Funciona como um agonista da guanilato ciclase-C, o que leva ao aumento dos níveis de monofosfato de guanosina cíclico (cGMP) nas células epiteliais intestinais. Essa ação promove a secreção de fluidos no lúmen intestinal e acelera o trânsito gastrointestinal, aliviando os sintomas de constipação. Linaclotida é caracterizado por sua relativamente baixa biodisponibilidade oral devido à sua natureza de peptídeo, o que limita sua absorção no trato gastrointestinal. A substância é tipicamente administrada em forma de cápsula e é conhecida por seu mecanismo de ação específico, que visa o revestimento intestinal em vez de vias sistêmicas. Efeitos colaterais comuns podem incluir diarreia, dor abdominal e flatulência. A eficácia e o perfil de segurança de Linaclotida foram estabelecidos por meio de ensaios clínicos, tornando-o uma opção valiosa no manejo de certos distúrbios gastrointestinais.

Linaclotide

CAS: 851199-59-2

Fórmula: C₅₉H₇₉N₁₅O₂₁S₆

Pureza: 99%

Cor e Forma: Solid

Peso molecular: 1526.7365

Ref: IN-DA00G3R9

Linaclotide

CAS: 851199-59-2

Linaclotide treats IBS-C & chronic constipation; it's a selective guanylate cyclase C agonist.

Fórmula: C₅₉H₇₉N₁₅O₂₁S₆

Pureza: 97.93% - 98.71%

Cor e Forma: Solid

Peso molecular: 1526.74

Ref: TM-T11852

Linaclotide

CAS: 851199-59-2

Fórmula: C₅₉H₇₉N₁₅O₂₁S₆

Peso molecular: 1526.73

Ref: 4Z-PL-121001

Linaclotide

CAS: 851199-59-2

Linaclotide

Pureza: ≥95%

Peso molecular: 1526.74g/mol

Ref: 54-BUP05450

Linaelotide Acetate

CAS: 851199-59-2

Fórmula: C₅₉H₇₉N₁₅O₂₁S₆

Pureza: 95%~99%

Cor e Forma: White to Off-white Powder

Peso molecular: 1526.74

Ref: BP-BPPG045

Linaclotide-d4

CAS: 851199-59-2

Fórmula: C₅₉H₇₅N₁₅O₂₁S₆D₄

Peso molecular: 1530.78

Ref: 4Z-PL-121002

Linaclotide

CAS: 851199-59-2

Linaclotide is a drug that is used in the treatment of chronic idiopathic constipation. It is formulated with the inactive ingredients microcrystalline cellulose, croscarmellose sodium, calcium stearate, and magnesium stearate. The active ingredient is linaclotide hydrochloride. Linaclotide works by increasing intestinal motility and reducing transit time through the gastrointestinal tract. It has been shown to be effective in treating constipation in adults with chronic idiopathic constipation when taken for up to 12 weeks. Linaclotide also may be used in combination with other treatments for bowel diseases such as ulcerative colitis or Crohn's disease.
Linaclotide is metabolized primarily by cytochrome P450 3A4 (CYP3A4) and subsequently eliminated from the body primarily by renal excretion of unchanged drug or metabolites. The drug has a half-life of about 4 hours following oral administration and

Fórmula: C₅₉H₇₉N₁₅O₂₁S₆

Pureza: Min. 98 Area-%

Cor e Forma: White Powder

Peso molecular: 1,526.74 g/mol

Ref: 3D-FL138962

Linaclotide

CAS: 851199-59-2

Linaclotide is a peptide drug that has been shown to be effective in treating chronic constipation. It belongs to the class of pharmacological agents and is used as a treatment for bowel disease, specifically chronic idiopathic constipation. Linaclotide increases the frequency of bowel movements by acting on the ileum and colon. This drug has been shown to be safe for use in pregnant women and children, with no adverse effects observed at doses up to 100 mcg/kg/day. The most common side effect is diarrhea, which can be managed with dietary changes or other medications. Linaclotide has not been found to interact with other drugs, but patients should always consult their doctor before taking any new medication while on linaclotide.

Fórmula: C₅₉H₇₉N₁₅O₂₁S₆

Pureza: Min. 95%

Peso molecular: 1,526.76 g/mol

Ref: 3D-LIN-3796-PI

Linaclotide

Produto Controlado

CAS: 851199-59-2

Applications Linaclotide is a guanylate cyclase-C agonist currently being studied in Phase 3 trials for the treatment of irritable bowel syndrome with constipation.
References Chey, W.D., et al.: Am. J. Gastroenterol., 107, 1702 (2012); Rao, S., et al.: Am. J. Gastroentrol., 107, 1714 (2012); Brierley, S.M., et al.: Curr. Opinion. Pharmacol., 12, 632 (2012);

Fórmula: C₅₉H₇₉N₁₅O₂₁S₆

Cor e Forma: Neat

Peso molecular: 1526.74

Ref: TR-L465880

Linaclotide-d4

Produto Controlado

CAS: 851199-59-2

Applications Linaclotide-d4 is the labeled analogue of a guanylate cyclase-C agonist currently being studied in Phase 3 trials for the treatment of irritable bowel syndrome with constipation.
References Chey, W.D., et al.: Am. J. Gastroenterol., 107, 1702 (2012); Rao, S., et al.: Am. J. Gastroentrol., 107, 1714 (2012); Brierley, S.M., et al.: Curr. Opinion. Pharmacol., 12, 632 (2012);

Fórmula: C₅₉H₇₅D₄N₁₅O₂₁S₆

Cor e Forma: Neat

Peso molecular: 1530.76

Ref: TR-L465882