CAS: 852808-04-9 - 4-[4-[(4′-Chloro[1,1′-biphenyl]-2-yl)methyl]-1-piperazinyl]-N-[[4-[[(1R)-3-(dimethylamino)-1-[(phenylthio)methyl]propyl]amino]-3-nitrophenyl]sulfonyl]benzamide

Fórmula: C₄₂H₄₅ClN₆O₅S₂

InChI: InChI=1S/C42H45ClN6O5S2/c1-46(2)23-22-35(30-55-37-9-4-3-5-10-37)44-40-21-20-38(28-41(40)49(51)52)56(53,54)45-42(50)32-14-18-36(19-15-32)48-26-24-47(25-27-48)29-33-8-6-7-11-39(33)31-12-16-34(43)17-13-31/h3-21,28,35,44H,22-27,29-30H2,1-2H3,(H,45,50)/t35-/m1/s1

Chave InChI: InChIKey=HPLNQCPCUACXLM-PGUFJCEWSA-N

SMILES: O=C(NS(=O)(=O)C1=CC=C(NC(CSC=2C=CC=CC2)CCN(C)C)C(=C1)N(=O)=O)C3=CC=C(C=C3)N4CCN(CC=5C=CC=CC5C6=CC=C(Cl)C=C6)CC4

Sinónimos:

• 4-[4-[(4'-Chloro[1,1'-biphenyl]-2-yl)methyl]-1-piperazinyl]-N-[[4-[[(1R)-3-(dimethylamino)-1-[(phenylthio)methyl]propyl]amino]-3-nitrophenyl]sulfonyl]benzamide
• 852808-04-9
• Abt 737
• Benzamide, 4-[4-[(4′-chloro[1,1′-biphenyl]-2-yl)methyl]-1-piperazinyl]-N-[[4-[[(1R)-3-(dimethylamino)-1-[(phenylthio)methyl]propyl]amino]-3-nitrophenyl]sulfonyl]-

ABT 737

CAS: 852808-04-9

• Fórmula: C₄₂H₄₅ClN₆O₅S₂
• Pureza: 97%
• Cor e Forma: Solid
• Peso molecular: 813.4269

ABT-737

CAS: 852808-04-9

ABT-737 is a BH3 mimetic and an inhibitor of Bcl-2, Bcl-xL, and Bcl-w. ABT-737 exhibits …

• Fórmula: C₄₂H₄₅ClN₆O₅S₂
• Pureza: 100% - 99.73%
• Cor e Forma: Solid
• Peso molecular: 813.43

ABT-737

CAS: 852808-04-9

ABT 737

CAS: 852808-04-9

Applications A selective inhibitor of BCL-2, in small cell lung cancer. ABT-737 induced dramatic regressions …

• Fórmula: C₄₂H₄₅ClN₆O₅S₂
• Cor e Forma: Off-White
• Peso molecular: 813.43

ABT 737

CAS: 852808-04-9

Inhibits anti-apoptotic proteins Bcl-2, Bcl-xl and Bcl-w. Synergistic with chemotherapy and radiotherapy in several tumour …

• Fórmula: C₄₂H₄₅ClN₆O₅S₂
• Pureza: Min. 95%
• Cor e Forma: Yellow Solid
• Peso molecular: 813.43 g/mol