CAS 859-18-7

Cloridrato de lincomicina

Descrição:

Cloridrato de lincomicina é um antibiótico que pertence à classe das lincosamidas, utilizado principalmente para tratar várias infecções bacterianas. É derivado da bactéria *Streptomyces lincolnensis*. A substância aparece como um pó cristalino branco a off-white e é solúvel em água, tornando-a adequada para administração parenteral. Cloridrato de lincomicina atua inibindo a síntese de proteínas bacterianas, direcionando-se efetivamente a bactérias Gram-positivas e alguns organismos anaeróbios. Seu mecanismo de ação envolve a ligação à subunidade 50S do ribossomo bacteriano, impedindo assim a elongação das cadeias peptídicas durante a tradução. Clinicamente, é frequentemente utilizado para tratar infecções da pele, do trato respiratório e de tecidos moles, particularmente em pacientes alérgicos à penicilina. No entanto, é essencial monitorar os potenciais efeitos colaterais, incluindo distúrbios gastrointestinais e o risco de diarreia associada ao Clostridium difficile. Assim como com todos os antibióticos, testes de suscetibilidade adequados são recomendados para garantir a eficácia contra a cepa bacteriana específica que está sendo tratada.

Fórmula: C₁₈H₃₄N₂O₆S·ClH

InChI: InChI=1S/C18H34N2O6S.ClH/c1-5-6-10-7-11(20(3)8-10)17(25)19-12(9(2)21)16-14(23)13(22)15(24)18(26-16)27-4;/h9-16,18,21-24H,5-8H2,1-4H3,(H,19,25);1H/t9-,10-,11+,12-,13+,14-,15-,16-,18-;/m1./s1

Chave InChI: InChIKey=POUMFISTNHIPTI-BOMBIWCESA-N

SMILES: [C@@H](NC(=O)[C@@H]1C[C@@H](CCC)CN1C)([C@@H](C)O)[C@]2(O[C@H](SC)[C@H](O)[C@@H](O)[C@H]2O)[H].Cl

Sinónimos:

• <span class="text-smallcaps">D</smallcap>-erythro-<smallcap>D</smallcap>-galacto-Octopyranoside, methyl 6,8-dideoxy-6-(1-methyl-4-propyl-<smallcap>L</span>-2-pyrrolidinecarboxamido)-1-thio-, monohydrochloride, trans-α-
• <span class="text-smallcaps">D</smallcap>-erythro-α-<smallcap>D</span>-galacto-Octopyranoside, methyl 6,8-dideoxy-6-[[(1-methyl-4-propyl-2-pyrrolidinyl)carbonyl]amino]-1-thio-, monohydrochloride, (2S-trans)-
• <span class="text-smallcaps">D</smallcap>-erythro-α-<smallcap>D</span>-galacto-Octopyranoside, methyl 6,8-dideoxy-6-[[[(2S,4R)-1-methyl-4-propyl-2-pyrrolidinyl]carbonyl]amino]-1-thio-, hydrochloride (1:1)
• <span class="text-smallcaps">D</smallcap>-erythro-α-<smallcap>D</span>-galacto-Octopyranoside, methyl 6,8-dideoxy-6-[[[(2S,4R)-1-methyl-4-propyl-2-pyrrolidinyl]carbonyl]amino]-1-thio-, monohydrochloride
• Lincocin
• Lincogap
• Lincomix
• Lincomycin Hcl
• Lincomycin Hydrochloride
• Lincomycin hydrochloride anhydrous
• NSC 70731
• U 10149a
• hydrogen chloride methyl 6,8-dideoxy-6-{[(4R)-1-methyl-4-propyl-L-prolyl]amino}-1-thio-D-erythro-alpha-D-gluco-octopyranoside (1:1:1)
• methyl 6,8-dideoxy-6-{[(4R)-1-methyl-4-propyl-L-prolyl]amino}-1-thio-D-erythro-alpha-D-galacto-octopyranoside hydrochloride
• methyl 6,8-dideoxy-6-{[(4R)-1-methyl-4-propyl-L-prolyl]amino}-1-thio-D-erythro-alpha-D-galacto-octopyranoside hydrochloride (1:1)
• D-erythro-α-D-galacto-Octopyranoside, methyl 6,8-dideoxy-6-[[(1-methyl-4-propyl-2-pyrrolidinyl)carbonyl]amino]-1-thio-, monohydrochloride, (2S-trans)-
• D-erythro-α-D-galacto-Octopyranoside, methyl 6,8-dideoxy-6-[[[(2S,4R)-1-methyl-4-propyl-2-pyrrolidinyl]carbonyl]amino]-1-thio-, hydrochloride (1:1)
• D-erythro-D-galacto-Octopyranoside, methyl 6,8-dideoxy-6-(1-methyl-4-propyl-L-2-pyrrolidinecarboxamido)-1-thio-, monohydrochloride, trans-α-

Lincomycin Hydrochloride Monohydrate

CAS: 154-21-2, 7179-49-9, 859-18-7

Fórmula: C₁₈H₃₄N₂O₆S·HCl·H₂O

Pureza: >98.0%(T)(qNMR)

Cor e Forma: White to Almost white powder to crystal

Peso molecular: 461.02

Ref: 3B-L0166

Lincomycin hydrochloride

CAS: 859-18-7

Lincomycin hydrochloride (HCl), 859-18-7, is the salt form of lincomycin, a lincosamide antibiotic which exhibits activity against gram-positive bacteria. Learn more.

Fórmula: C₁₈H₃₅ClN₂O₆S

Cor e Forma: White, Crystalline Powder

Peso molecular: 443.00

Ref: 02-J61251

Lincomycin hydrochloride

CAS: 859-18-7

Lincomycin hydrochloride

Fórmula: C₁₈H₃₄N₂O₆S

Pureza: 86.9%

Cor e Forma: White

Peso molecular: 406.21376

Ref: 47-215

D-erythro-a-D-galacto-Octopyranoside, methyl6,8-dideoxy-6-[[[(2S,4R)-1-methyl-4-propyl-2-pyrrolidinyl]carbonyl]amino]-1-thio-, monohydrochloride

CAS: 859-18-7

Fórmula: C₁₈H₃₅ClN₂O₆S

Pureza: 95%

Cor e Forma: Solid

Peso molecular: 442.9983

Ref: IN-DA00IDT6

Lincomycin hydrochloride, EP grade

CAS: 859-18-7

Fórmula: C₁₈H₃₄N₂O₆S·HCl·xH₂O

Pureza: 96.0 - 102.0 % (Lincomycin hydrochloride + Lincomycin B hydrochloride (anhydrous basis))

Cor e Forma: White or almost white crystalline powder

Peso molecular: 443.00 (anhydrous)

Ref: 7W-GP0215

Lincomycin hydrochloride

CAS: 859-18-7

Fórmula: C₁₈H₃₄N₂O₆S·HCl·xH₂O

Pureza: 90.0 - 102.0 % (C18H35ClN2O6S, anhydrous basis)

Cor e Forma: White or almost white crystalline powder

Peso molecular: 443.00 (anhydrous)

Ref: 7W-GA3892

Lincomycin HCl (Clindamycin Phosphate EP Impurity A HCl)

CAS: 859-18-7

Fórmula: C₁₈H₃₄N₂O₆S·HCl

Peso molecular: 406.54 36.46

Ref: 4Z-L-093013

Lincomycin hydrochloride

CAS: 859-18-7

Lincomycin hydrochloride

Pureza: ≥95%

Peso molecular: 443g/mol

Ref: 54-BUP16885

Lincomycin hydrochloride

CAS: 859-18-7

Lincomycin hydrochloride (U10149A) is a lincosamide antibiotic identified in S.lincolnensis with activity against gram-positive cocci and anaerobic bacteria.

Fórmula: C₁₈H₃₄N₂O₆S·HCl

Pureza: 97% - >99.99%

Cor e Forma: Crystalline

Peso molecular: 443

Ref: TM-T1277

Lincomycin hydrochloride

CAS: 859-18-7

Lincomycin hydrochloride

Pureza: 90%

Cor e Forma: Solid

Peso molecular: 443.00g/mol

Ref: 54-BIL0127

Lincomycin Hydrochloride Monohydrate

Produto Controlado

CAS: 7179-49-9, 859-18-7

Fórmula: C₁₈H₃₄N₂O₆SClHH₂O

Cor e Forma: Neat

Peso molecular: 461.01

Ref: 86-MM0320.00

Lincomycin Hydrochloride

Produto Controlado

CAS: 859-18-7

Applications An antibiotic produced by Streptomyces lincolnensis. Lincomycin is a lincosamide antibiotic that forms cross-links within the peptidyl transferase loop region of the 23S rRNA. Inhibits bacterial protein synthesis. Antibacterial.
References Mason, D.J., et al.: Antimicrob. Agents Chemother., 555 (1962), Gray, et al.: Toxicol. Appl. Pharmacol., 6, 476 (1964), Muti, H.Y., et al.: Anal. Profiles Drug Subs. Excip., 23, 269 (1994),

Fórmula: C₁₈H₃₄N₂O₆S·ClH

Cor e Forma: White To Off-White

Peso molecular: 443.00

Ref: TR-L466200

Lincomycin hydrochloride

CAS: 859-18-7

Lincomycin is active against gram-positive bacteria such as staphylococci, streptococci, pneumococci, diphtheria bacillus, and clostridia. It is used to treat severe bacterial infections including: sepsis, osteomyelitis, septic endocarditis, pneumonia, pulmonary abscess, infected wounds, purulent meningitis and severe pseudomembranous colitis. Lincomycin is an alternative antibiotic for penicillin-resistant gram-positive bacteria.

Fórmula: C₁₈H₃₅ClN₂O₆S

Pureza: Min. 95%

Cor e Forma: Off-White Powder

Peso molecular: 443 g/mol

Ref: 3D-AL16775