CAS 863918-55-2

5H-Pirano[3,2-d]tiazol-6,7-diol, 3a,6,7,7a-tetrahidro-5-(hidroximetil)-2-propil-, (3aR,5R,6S,7R,7aR)-

Descrição:

5H-Pirano[3,2-d]tiazol-6,7-diol, 3a,6,7,7a-tetrahidro-5-(hidroximetil)-2-propilo-, com número CAS 863918-55-2, é um composto orgânico complexo caracterizado por sua estrutura bicíclica única que incorpora tanto um moiety de pirano quanto de tiazol. Este composto apresenta múltiplos grupos funcionais, incluindo grupos hidroximetil e diol, que contribuem para sua potencial reatividade e solubilidade em vários solventes. A estereoquímica indicada pela designação (3aR,5R,6S,7R,7aR) sugere arranjos espaciais específicos de seus átomos, que podem influenciar sua atividade biológica e interações com outras moléculas. Compostos como esses podem exibir propriedades farmacológicas interessantes, tornando-os de interesse na química medicinal. A presença do grupo propilo melhora suas características hidrofóbicas, afetando potencialmente sua biodisponibilidade e interação com membranas biológicas. No geral, a complexidade estrutural e a diversidade funcional deste composto sugerem aplicações potenciais no desenvolvimento de medicamentos e em outros campos da pesquisa química.

Fórmula: C₁₀H₁₇NO₄S

Sinónimos:

• 5H-Pyrano[3,2-d]thiazole-6,7-diol, 3a,6,7,7a-tetrahydro-5-(hydroxymethyl)-2-propyl-, (3aR,5R,6S,7R,7aR)-

NButGT - Bio-X ™

CAS: 863918-55-2

NButGT (N-butyryl-glucosamine-1,5-lactone O-(phenylcarbamoyl)oxime) is a selective inhibitor of O-GlcNAcase (OGA), the enzyme responsible for removing O-linked N-acetylglucosamine (O-GlcNAc) modifications from proteins. It effectively increases O-GlcNAc levels in cells and tissues without altering hexosamine biosynthetic pathway enzyme expression. It has also been shown that NButGT rapidly increases O-GlcNAcylation of mitochondrial proteins involved in oxidative phosphorylation and metabolism. While effective, NButGT served as a precursor to more potent OGA inhibitors like Thiamet-G. These findings highlight NButGT's importance as a tool for studying O-GlcNAcylation in various biological contexts, particularly in cardiac and neurological research. For example, in recent cardiac studies, NButGT pretreatment has demonstrated an improvement in cardiac output and mitochondrial respiration when combined with epinephrine.  Linagliptin is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.

Fórmula: C₁₀H₁₇NO₄S

Pureza: Min. 95%

Cor e Forma: Powder

Peso molecular: 247.31 g/mol

Ref: 3D-BN300156

NButGT

CAS: 863918-55-2

NButGT (N-butyryl-glucosamine-1,5-lactone O-(phenylcarbamoyl)oxime) is a selective inhibitor of O-GlcNAcase (OGA), the enzyme responsible for removing O-linked N-acetylglucosamine (O-GlcNAc) modifications from proteins. It effectively increases O-GlcNAc levels in cells and tissues without altering hexosamine biosynthetic pathway enzyme expression. It has also been shown that NButGT rapidly increases O-GlcNAcylation of mitochondrial proteins involved in oxidative phosphorylation and metabolism. While effective, NButGT served as a precursor to more potent OGA inhibitors like Thiamet-G. These findings highlight NButGT's importance as a tool for studying O-GlcNAcylation in various biological contexts, particularly in cardiac and neurological research. For example, in recent cardiac studies, NButGT pretreatment has demonstrated an improvement in cardiac output and mitochondrial respiration when combined with epinephrine.

Fórmula: C₁₀H₁₇NO₄S

Pureza: Min. 95%

Cor e Forma: Powder

Peso molecular: 247.31 g/mol

Ref: 3D-NN180123