CAS 87081-36-5

(2E,5S,6R,7S,9R,10E,12E,15R,16Z,18E)-19-[(2S,3S)-3,6-Diidro-3-metil-6-oxo-2H-pirano-2-il]-6-hidroxi-3,5,7,9,11,15,17-heptametil-8-oxo-2,10,12,16,18-nonadecapentaenoico ácido

Descrição:

A substância química com o nome "(2E,5S,6R,7S,9R,10E,12E,15R,16Z,18E)-19-[(2S,3S)-3,6-Diidro-3-metil-6-oxo-2H-pirano-2-il]-6-hidroxi-3,5,7,9,11,15,17-heptametil-8-oxo-2,10,12,16,18-nonadecapentaenoico ácido" e número CAS "87081-36-5" é um composto orgânico complexo caracterizado por seus múltiplos estereocentros e grupos funcionais. Apresenta uma longa cadeia de carbono com várias ligações duplas, indicando que provavelmente é um derivado de um ácido graxo poli-insaturado. A presença de grupos hidroxila e ceto sugere que pode exibir reatividade significativa e potencial atividade biológica. A estereoquímica específica, denotada pelas configurações (E) e (Z), implica que o composto pode ter arranjos espaciais únicos que afetam suas interações em sistemas biológicos. Esses compostos são frequentemente estudados por seus papéis em produtos naturais, aplicações terapêuticas potenciais ou como intermediários na química sintética. No geral, essa substância exemplifica a complexidade e diversidade encontradas na química orgânica, particularmente no âmbito da síntese e modificação de produtos naturais.

Fórmula: C₃₂H₄₆O₆

InChI: InChI=1/C32H46O6/c1-20(16-22(3)12-14-28-24(5)13-15-30(35)38-28)10-9-11-21(2)17-25(6)31(36)27(8)32(37)26(7)18-23(4)19-29(33)34/h9,11-17,19-20,24-28,32,37H,10,18H2,1-8H3,(H,33,34)/b11-9+,14-12+,21-17+,22-16+,23-19+

Chave InChI: InChIKey=QECBVZBMGUAZDL-WRDLAOIUSA-N

SMILES: C(=C/C(=C\[C@@H](C/C=C/C(=C/[C@H](C([C@H]([C@@H]([C@H](C/C(=C/C(O)=O)/C)C)O)C)=O)C)/C)C)/C)\[C@H]1[C@@H](C)C=CC(=O)O1

Sinónimos:

• (2E,10E,12E,16Z,18E)-6-hydroxy-3,5,7,9,11,15,17-heptamethyl-19-(3-methyl-6-oxo-3,6-dihydro-2H-pyran-2-yl)-8-oxononadeca-2,10,12,16,18-pentaenoic acid
• (2E,5S,6R,7S,9R,10E,12E,15R,16Z,18E)-19-[(2S,3S)-3,6-Dihydro-3-methyl-6-oxo-2H-pyran-2-yl]-6-hydroxy-3,5,7,9,11,15,17-heptamethyl-8-oxo-2,10,12,16,18-nonadecapentaenoic acid
• 2,10,12,16,18-Nonadecapentaenoic acid, 19-(3,6-dihydro-3-methyl-6-oxo-2H-pyran-2-yl)-3,5,7,9,11,15,17-heptamethyl-6-hydroxy-8-oxo
• 2,10,12,16,18-Nonadecapentaenoic acid, 19-(3,6-dihydro-3-methyl-6-oxo-2H-pyran-2-yl)-6-hydroxy-3,5,7,9,11,15,17-heptamethyl-8-oxo-
• 2,10,12,16,18-Nonadecapentaenoic acid, 19-[(2S,3S)-3,6-dihydro-3-methyl-6-oxo-2H-pyran-2-yl]-6-hydroxy-3,5,7,9,11,15,17-heptamethyl-8-oxo-, (2E,5S,6R,7S,9R,10E,12E,15R,16Z,18E)-
• Jildamycin
• Leptomycin A
• NSC 369326
• QECBVZBMGUAZDL-DLWOFZAMSA-N
• 19-(3,6-Dihydro-3-methyl-6-oxo-2H-pyran-2-yl)-6-hydroxy-3,5,7,9,11,15,17-heptamethyl-8-oxo-2,10,12,16,18-nonadecapentaenoic acid
• 2,10,12,16,18-Nonadecapentaenoicacid,19-[(2S,3S)-3,6-dihydro-3-methyl-6-oxo-2H-pyran-2-yl]-6-hydroxy-3,5,7,9,11,15,17-heptamethyl-8-oxo-,(2E,5S,6R,7S,9R,10E,12E,15R,16Z,18E)-
• Antibiotic ATS-1287A
• PD-118607
• ATS 1287A, PD 118607, JildaMycin
• 19-(3,6-dihydro-3-methyl-6-oxo-2h-pyran-2-yl)-3,5,7,9,11,15,17-heptamethyl-6-hydroxy-8-oxo-2,10,12,16,18-nonadecapentaenoic acid
• Antibiotic PD-118607

Leptomycin A

CAS: 87081-36-5

Fórmula: C₃₂H₄₆O₆

Peso molecular: 526.7

Ref: 7W-GA3048

Leptomycin A

CAS: 87081-36-5

Leptomycin A

Peso molecular: 526.70g/mol

Ref: 54-BIL2100

Leptomycin A

CAS: 87081-36-5

Leptomycin A from Streptomyces inhibits CRM1, reducing HIV-1 replication, less potent than Leptomycin B, blocks protein nuclear export.

Fórmula: C₃₂H₄₆O₆

Pureza: 98%

Cor e Forma: Solid

Peso molecular: 526.7

Ref: TM-T11837

Leptomycin A

CAS: 87081-36-5

Leptomycin A is a Streptomyces-produced inhibitor, which is derived from the bacterium Streptomyces spiroverticillatus. It functions by specifically binding to and inhibiting the CRM1 (exportin 1), a nuclear export receptor. This action blocks the nuclear export of proteins that contain a leucine-rich nuclear export signal (NES), thereby leading to their accumulation within the nucleus. The inhibition of CRM1 disrupts various cellular processes, including cell cycle regulation and signal transduction pathways.

Fórmula: C₃₂H₄₆O₆

Pureza: Min. 95%

Peso molecular: 526.7 g/mol

Ref: 3D-MDA08136