CAS 87096-84-2

neuromedina B

Descrição:

neuromedina B é um neuropeptídeo que desempenha um papel significativo em vários processos fisiológicos, incluindo a regulação da contração do músculo liso e a modulação das funções neuroendócrinas. É composto por uma sequência de aminoácidos e é classificado como um membro da família de neuromedinas, que estão envolvidas na neurotransmissão e sinalização dentro do sistema nervoso central. neuromedina B atua principalmente através de receptores específicos, influenciando processos como a regulação do apetite, a resposta ao estresse e as funções reprodutivas. O peptídeo é conhecido por estar envolvido na fisiopatologia de certas condições, incluindo obesidade e transtornos de ansiedade. Sua estrutura geralmente inclui uma amidação C-terminal, que é crucial para sua atividade biológica. neuromedina B é sintetizado em vários tecidos, incluindo o cérebro e o trato gastrointestinal, e seus efeitos são mediados por interações com receptores acoplados a proteínas G. A pesquisa continua a explorar suas potenciais aplicações terapêuticas, particularmente no contexto de distúrbios metabólicos e neuropsiquiátricos.

Fórmula: C₅₂H₇₃N₁₅O₁₂S

InChI: InChI=1/C52H73N15O12S/c1-27(2)17-36(64-51(78)40(21-41(54)69)61-42(70)22-53)48(75)66-38(19-31-23-57-34-14-10-9-13-33(31)34)47(74)60-28(3)46(73)67-44(29(4)68)52(79)58-25-43(71)62-39(20-32-24-56-26-59-32)50(77)65-37(18-30-11-7-6-8-12-30)49(76)63-35(45(55)72)15-16-80-5/h6-14,23-24,26-29,35-40,44,57,68H,15-22,25,53H2,1-5H3,(H2,54,69)(H2,55,72)(H,56,59)(H,58,79)(H,60,74)(H,61,70)(H,62,71)(H,63,76)(H,64,78)(H,65,77)(H,66,75)(H,67,73)/t28-,29+,35-,36-,37?,38-,39-,40-,44-/m0/s1

Sinónimos:

• H-Gly-Asn-Leu-Trp-Ala-Thr-Gly-His-Phe-Met-NH2
• (2S)-2-[(2-aminoacetyl)amino]-N-[(1S)-1-[[(1S)-2-[[(1S)-2-[[(1S,2R)-1-[[2-[[(1S)-2-[[1-benzyl-2-[[(1S)-1-carbamoyl-3-methylsulfanyl-propyl]amino]-2-oxo-ethyl]amino]-1-(3H-imidazol-4-ylmethyl)-2-oxo-ethyl]amino]-2-oxo-ethyl]carbamoyl]-2-hydroxy-propyl]amino]-1-methyl-2-oxo-ethyl]amino]-1-(1H-indol-3-ylmethyl)-2-oxo-ethyl]carbamoyl]-3-methyl-butyl]butanediamide

Neuromedin B

CAS: 87096-84-2

For cellular and molecular biology applications

Fórmula: C₅₂H₇₃N₁₅O₁₂S

Cor e Forma: Lyophilized powder

Peso molecular: 1132.3

Ref: 02-J66286

Neuromedin B

CAS: 87096-84-2

NMB, a bombesin-linke peptide, binds to the bombesin receptors BRS1-4. NMB is expressed in the pituitary, brain, pancreas, adrenal and gastrointestinal tract. Its expression in adipose tissue appears to be regulated by changes in energy balance. NMB could inhibit food intake and modulates stress-related behavior.

Fórmula: C₅₂H₇₃N₁₅O₁₂S

Pureza: 97.4%

Cor e Forma: White Powder

Peso molecular: 1132.31

Ref: 01-4020211

Neuromedin B

CAS: 87096-84-2

Neuromedin B

Pureza: ≥98%

Peso molecular: 1132.29g/mol

Ref: 54-BUP01758

Neuromedin B

CAS: 87096-84-2

Neuromedin B, a mammalian peptide related to bombesin, is found in the CNS and GI tract, originally purified from pig spinal cords.

Fórmula: C₅₂H₇₃N₁₅O₁₂S

Pureza: 99.39%

Cor e Forma: Solid

Peso molecular: 1132.29

Ref: TM-TP1442

Neuromedin B (porcine)

CAS: 87096-84-2

Custom research peptide; min purity 95%. For different specs please use the Peptide Quote Tool

Fórmula: C₅₂H₇₃N₁₅O₁₂S

Peso molecular: 1,132.3 g/mol

Ref: 3D-PP50044

Neuromedin C (Human, Porcine, Canine)

CAS: 87096-84-2

Neuromedin C (NMC) is a peptide that belongs to the family of neuromedin and is a potent activator of ion channels. It has been shown to be a ligand for opioid receptors, which may be due to its ability to inhibit the release of neurotransmitters such as acetylcholine and noradrenaline. Neuromedin C has also been shown to inhibit the binding of morphine-6 beta-glucuronide in rat brain synaptosomes. In addition, NMC has been reported as an inhibitor of cell proliferation and induce apoptosis in various cancer cells including colon and prostate cancers.

Fórmula: C₅₀H₇₃N₁₇O₁₁S

Pureza: Min. 95%

Peso molecular: 1,120.3 g/mol

Ref: 3D-PNM-4153-V

Neuromedin B (Human, Porcine, Rat)

CAS: 87096-84-2

Neuromedin B is a neuropeptide that has been shown to activate the TRPC ion channels in mammalian cells. It also has been shown to bind to receptors and have a potent effect on cell biology, as well as being used as a research tool for studying protein interactions. Neuromedin B is found in humans, pigs, and rats, where it is expressed primarily in the brain and gastrointestinal tract. This peptide has been shown to be an inhibitor of some types of ion channels.

Fórmula: C₅₂H₇₃N₁₅O₁₂S

Pureza: Min. 95%

Peso molecular: 1,132.3 g/mol

Ref: 3D-PNM-4152-V

Neuromedin B trifluoroacetate salt

CAS: 87096-84-2

Neuromedin B is a peptide hormone that is produced by the hypothalamus and regulates many physiological processes such as energy metabolism, appetite, and sleep. Neuromedin B is a member of the family of guanine nucleotide-binding proteins (G proteins) that bind to G protein-coupled receptors on the surface of cells. It has been shown to stimulate calcium release from intracellular stores in response to an increase in cytosolic Ca2+. Neuromedin B has been shown to have anti-inflammatory effects on infectious diseases such as meningitis, sepsis, and tuberculosis, which may be due to its ability to inhibit neutrophil migration. Neuromedin B also stimulates hippocampal formation activity in rats during the rotarod test, which may be due to its effects on dopamine release.

Fórmula: C₅₂H₇₃N₁₅O₁₂S

Pureza: Min. 95%

Peso molecular: 1,132.3 g/mol

Ref: 3D-FN108954