CAS 871224-64-5

Almorexant

Descrição:

Almorexant é um composto químico classificado como um antagonista dual dos receptores de orexina, investigado principalmente por seu potencial uso no tratamento da insônia e outros distúrbios do sono. Funciona bloqueando seletivamente a ação dos neuropeptídeos de orexina, que desempenham um papel crucial na regulação da excitação, vigília e apetite. A estrutura molecular de Almorexant apresenta uma disposição complexa que contribui à sua atividade farmacológica, embora detalhes específicos sobre suas propriedades físicas, como solubilidade e estabilidade, sejam tipicamente encontrados em bancos de dados especializados ou literatura científica. Almorexant passou por vários ensaios clínicos para avaliar sua eficácia e perfil de segurança, demonstrando promessas na promoção do sono sem os efeitos adversos comumente associados a sedativos tradicionais. Assim como muitos medicamentos em investigação, seu status de desenvolvimento pode variar, e a pesquisa em andamento continua a explorar seu potencial terapêutico completo e mecanismo de ação.

Fórmula: C₂₉H₃₁F₃N₂O₃

InChI: InChI=1S/C29H31F3N2O3/c1-33-28(35)27(20-7-5-4-6-8-20)34-16-15-21-17-25(36-2)26(37-3)18-23(21)24(34)14-11-19-9-12-22(13-10-19)29(30,31)32/h4-10,12-13,17-18,24,27H,11,14-16H2,1-3H3,(H,33,35)/t24-,27+/m0/s1

Chave InChI: InChIKey=DKMACHNQISHMDN-RPLLCQBOSA-N

SMILES: C(CC1=CC=C(C(F)(F)F)C=C1)[C@H]2C=3C(=CC(OC)=C(OC)C3)CCN2[C@@H](C(NC)=O)C4=CC=CC=C4

Sinónimos:

• (R)-2-((R)-6,7-Dimethoxy-1-(4-(Trifluoromethyl)Phenethyl)-3,4-Dihydroisoquinolin-2(1H)-Yl)-N-Methyl-2-Phenylacetamide
• (αR,1S)-3,4-Dihydro-6,7-dimethoxy-N-methyl-α-phenyl-1-[2-[4-(trifluoromethyl)phenyl]ethyl]-2(1H)-isoquinolineacetamide
• 2(1H)-Isoquinolineacetamide, 3,4-dihydro-6,7-dimethoxy-N-methyl-α-phenyl-1-[2-[4-(trifluoromethyl)phenyl]ethyl]-, (αR,1S)-
• Act-078573
• Act-078573(R)-2-((R)-6,7-dimethoxy-1-(4-(trifluoromethyl)phenethyl)-3,4-dihydroisoquinolin-2(1H)-yl)-N-methyl-2-phenylacetamide
• Almorexant
• AlMorexant (hydrochloride)
• CS-1665
• almorexant (ACT-078573), CID 23727689
• ACT-078573;ACT 078573;ACT078573
• (2R)-2-((1S)-6,7-Dimethoxy-1-{2-(4-(trifluoromethyl)phenyl)ethyl}-3,4-dihydroisoquinolin-2(1H)-yl)-N-methyl-2-phenylacetamide
• almorexant (ACT-078573)
• 2-(6,7-dimethoxy-1-(4-(trifluoromethyl)phenethyl)-3,4-dihydroisoquinolin-2(1H)-yl)-N-methyl-2-phenylacetamide
• (2R)-2-[(1S)-6,7-DIMETHOXY-1-[2-[4-(TRIFLUOROMETHYL)PHENYL]ETHYL]-3,4-DIHYDRO-1H-ISOQUINOLIN-2-YL]-N-METHYL-2-PHENYLACETAMIDE
• Almorexant [inn]
• AlMorexant HCl

Almorexant

CAS: 871224-64-5

Almorexant

Pureza: ≥95%

Peso molecular: 512.56g/mol

Ref: 54-BUP03376

Almorexant-13C-d3

CAS: 871224-64-5

Fórmula: C₂₈₁₃CH₂₈D₃F₃N₂O₃

Cor e Forma: Pale Yellow Solid

Peso molecular: 516.58

Ref: 4Z-A-201002

Almorexant

CAS: 871224-64-5

Fórmula: C₂₉H₃₁F₃N₂O₃

Cor e Forma: Pale Yellow Solid

Peso molecular: 512.58

Ref: 4Z-A-201001

Almorexant

CAS: 871224-64-5

Almorexant (ACT 078573), a strong dual orexin receptor antagonist, has Ki of 1.3 nM for OX1 and 0.17 nM for OX2.

Fórmula: C₂₉H₃₁F₃N₂O₃

Pureza: 97.75% - 98.02%

Cor e Forma: Solid

Peso molecular: 512.56

Ref: TM-T2613

Almorexant

CAS: 871224-64-5

Almorexant is a pharmacological agent that is used to treat insomnia. It is an orexin receptor antagonist and has been approved for the treatment of chronic insomnia in adults. Almorexant binds to the α1 subunit of the orexin receptors, which are located in the hypothalamus and have been shown to be involved in energy metabolism, locomotor activity, and sleep regulation. This drug inhibits neuronal excitation by blocking these receptors and can reduce wakefulness-promoting signaling. In humans, almorexant has been shown to produce a concentration-dependent decrease in wakefulness and increased sleep time when given at doses of 0.5mg or 1mg. Almorexant also has a significant effect on locomotor activity in animals with no effect on energy metabolism or body temperature.

Fórmula: C₂₉H₃₁F₃N₂O₃

Pureza: Min. 95%

Peso molecular: 512.56 g/mol

Ref: 3D-FA103508

Almorexant

CAS: 871224-64-5

Fórmula: C₂₉H₃₁F₃N₂O₃

Peso molecular: 512.58

Ref: ST-EA-CP-A313002