CAS 873857-62-6

Fidaxomicina

Descrição:

Fidaxomicina é um antibiótico macrolídeo usado principalmente para o tratamento de infecções por Clostridium difficile. É caracterizado por seu mecanismo de ação único, que envolve a inibição da RNA polimerase bacteriana, impedindo assim a síntese de proteínas bacterianas. Essa inibição seletiva permite que Fidaxomicina atinja efetivamente C. difficile enquanto preserva a flora intestinal normal, que é crucial para a manutenção da saúde intestinal. O composto é mal absorvido sistemicamente, levando a altas concentrações no trato gastrointestinal, o que aumenta sua eficácia contra infecções intestinais. Fidaxomicina é tipicamente administrado por via oral e é conhecido por seu perfil de segurança favorável, com menos efeitos colaterais gastrointestinais em comparação com outros antibióticos. Sua estrutura química apresenta um complexo anel de lactona macrocíclica, que contribui para suas propriedades antibacterianas. O medicamento é frequentemente preferido em casos de infecções recorrentes por C. difficile devido à sua capacidade de reduzir as taxas de recorrência. No geral, Fidaxomicina representa um avanço significativo no tratamento da diarreia associada a antibióticos causada por C. difficile, oferecendo uma abordagem direcionada com mínima interrupção do microbioma intestinal.

Fórmula: C₅₂H₇₄Cl₂O₁₈

InChI: InChI=1S/C52H74Cl2O18/c1-13-30-22-26(6)33(56)18-16-15-17-31(23-66-51-45(65-12)42(61)44(29(9)67-51)69-49(64)35-32(14-2)36(53)39(58)37(54)38(35)57)48(63)68-34(28(8)55)20-19-25(5)21-27(7)43(30)70-50-41(60)40(59)46(52(10,11)72-50)71-47(62)24(3)4/h15-17,19,21-22,24,28-30,33-34,40-46,50-51,55-61H,13-14,18,20,23H2,1-12H3/b16-15+,25-19+,26-22+,27-21+,31-17+/t28-,29-,30+,33+,34+,40-,41+,42+,43+,44-,45+,46+,50-,51-/m1/s1

Chave InChI: InChIKey=ZVGNESXIJDCBKN-UUEYKCAUSA-N

SMILES: C(O[C@H]1[C@H](O)[C@H](OC)[C@H](OC\C=2\C(=O)O[C@]([C@@H](C)O)(C/C=C(\C)/C=C(\C)/[C@H](O[C@H]3[C@@H](O)[C@@H](O)[C@H](OC(C(C)C)=O)C(C)(C)O3)[C@@H](CC)/C=C(\C)/[C@@H](O)C\C=C\C2)[H])O[C@@H]1C)(=O)C4=C(CC)C(Cl)=C(O)C(Cl)=C4O

Sinónimos:

• (3E,5E,8S,9E,11S,12R,13E,15E,18S)-3-[[[6-Deoxy-4-O-(3,5-dichloro-2-ethyl-4,6-dihydroxybenzoyl)-2-O-methyl-β-<span class="text-smallcaps">D</smallcap>-mannopyranosyl]oxy]methyl]-12-[[6-deoxy-5-C-methyl-4-O-(2-methyl-1-oxopropyl)-β-<smallcap>D</span>-lyxo-hexopyranosyl]oxy]-11-ethyl-8-hydroxy-18-[(1R)-1-hydroxyethyl]-9,13,15-trimethyloxacyclooctadeca-3,5,9,13,15-pentaen-2-one
• 3-(((6-Deoxy-4-O-(3,5-dichloro-2-ethyl-4,6-dihydroxybenzoyl)-2-O-methyl-b-D-mannopyranosyl)oxy)-methyl)-12(R)-[(6-deoxy-5-C-methyl-4-O-(2-methyl-1-oxopropyl)-b-D-lyxo-hexopyranosyl)oxy]-11(S)-ethyl-8(S)-hydroxy-18(S)-(1(R)-hydroxyethyl)-9,13,15-trimethyloxacyclooctadeca-3,5,9,13,15-pentaene-2-one
• Clostomicin B₁
• Dificid
• Dificlir
• Fidaxomycin
• Lipiarmicin
• Lipiarmycin
• Lipiarmycin A 3
• Opt-80
• Oxacyclooctadeca-3,5,9,13,15-pentaen-2-one, 3-[[[6-deoxy-4-O-(3,5-dichloro-2-ethyl-4,6-dihydroxybenzoyl)-2-O-methyl-β-<span class="text-smallcaps">D</smallcap>-mannopyranosyl]oxy]methyl]-12-[[6-deoxy-5-C-methyl-4-O-(2-methyl-1-oxopropyl)-β-<smallcap>D</span>-lyxo-hexopyranosyl]oxy]-11-ethyl-8-hydroxy-18-[(1R)-1-hydroxyethyl]-9,13,15-trimethyl-, (3E,5E,8S,9E,11S,12R,13E,15E,18S)-
• Par 01
• Par-101
• R-Tiacumicin B
• Tiacumicin B
• (3E,5E,8S,9E,11S,12R,13E,15E,18S)-3-[[[6-Deoxy-4-O-(3,5-dichloro-2-ethyl-4,6-dihydroxybenzoyl)-2-O-methyl-β-D-mannopyranosyl]oxy]methyl]-12-[[6-deoxy-5-C-methyl-4-O-(2-methyl-1-oxopropyl)-β-D-lyxo-hexopyranosyl]oxy]-11-ethyl-8-hydroxy-18-[(1R)-1-hydroxyethyl]-9,13,15-trimethyloxacyclooctadeca-3,5,9,13,15-pentaen-2-one
• Oxacyclooctadeca-3,5,9,13,15-pentaen-2-one, 3-[[[6-deoxy-4-O-(3,5-dichloro-2-ethyl-4,6-dihydroxybenzoyl)-2-O-methyl-β-D-mannopyranosyl]oxy]methyl]-12-[[6-deoxy-5-C-methyl-4-O-(2-methyl-1-oxopropyl)-β-D-lyxo-hexopyranosyl]oxy]-11-ethyl-8-hydroxy-18-[(1R)-1-hydroxyethyl]-9,13,15-trimethyl-, (3E,5E,8S,9E,11S,12R,13E,15E,18S)-

Fidaxomicin

CAS: 873857-62-6

Fórmula: C₅₂H₇₄Cl₂O₁₈

Pureza: >98.0%(HPLC)

Cor e Forma: White to Light yellow powder to crystal

Peso molecular: 1,058.05

Ref: 3B-F1216

Fidaxomycin; Lipiarmycin A3; Tiacumicin B; Chlostomicin B1;

CAS: 873857-62-6

Fórmula: C₅₂H₇₄CL₂O₁₈

Pureza: 98.89%

Cor e Forma: Off white. Powder

Peso molecular: 1056.0

Ref: 8R-CL0228

Fidaxomicin

CAS: 873857-62-6

Fidaxomicin

Fórmula: C₅₂H₇₄Cl₂O₁₇

Pureza: By hplc: 98.48% (Typical Value in Batch COA)

Cor e Forma: white to off-white powder

Peso molecular: 1,042.04g/mol

Ref: 54-BIW4203

Fidaxomicin

CAS: 873857-62-6

Fidaxomicin

Pureza: ≥98%

Peso molecular: 1058.04g/mol

Ref: 54-BUP15040

Fidaxomicin

CAS: 873857-62-6

Fórmula: C₅₂H₇₄Cl₂O₁₈

Pureza: ≥ 97.0%

Cor e Forma: White to off-white powder

Peso molecular: 1058.0

Ref: 7W-GA3227

Fidaxomicin

CAS: 873857-62-6

Fórmula: C₅₂H₇₄Cl₂O₁₈

Cor e Forma: White To Off-White Solid

Peso molecular: 1058.05

Ref: 4Z-F-076001

Fidaxomicin

CAS: 873857-62-6

Fidaxomicin (Tiacumicin B) is a semisynthetic macrolide antibiotic used to treat Clostridium difficile-associated diarrhea in adults.

Fórmula: C₅₂H₇₄Cl₂O₁₈

Pureza: 99.76% - 99.82%

Cor e Forma: Solid

Peso molecular: 1058.04

Ref: TM-T6194

Fidaxomicin

CAS: 873857-62-6

Applications Fidaxomicin is a nonabsorbed macrocyclic antibiotic, and is the first antimicrobial to be approved by the FDA for the treatment of Clostridium difficile infection (CDI) in 20 years. Fidaxomicin works by inhibiting sporulation by CDI, sustaining clinical response and reducing recurrences of this pathogen.
References Babakhani, F., et al.: Clin. Infect. Dis., 55, S162 (2012); Venugopal, A., et al.: Clin. Infect. Dis., 54, 568 (2012)

Fórmula: C₅₂H₇₄Cl₂O₁₈

Cor e Forma: Neat

Peso molecular: 1058.04

Ref: TR-F335400

Fidaxomicin

CAS: 873857-62-6

Fidaxomicin is a macrocyclic antibiotic with action on bacterial RNA polymerase and is used for treating Clostridium difficile infections.

Fórmula: C₅₂H₇₄Cl₂O₁₈

Pureza: Min. 98 Area-%

Cor e Forma: White Powder

Peso molecular: 1,058.04 g/mol

Ref: 3D-AF31015