CAS 88321-09-9

Loxistatina

Descrição:

Loxistatina, com o número CAS 88321-09-9, é um composto sintético conhecido principalmente por seu papel como um potente inibidor da enzima HMG-CoA redutase, que é crucial na via de biossíntese do colesterol. Essa característica posiciona Loxistatina como um potencial agente terapêutico no manejo da hiperlipidemia e condições cardiovasculares relacionadas. O composto exibe uma estrutura química específica que contribui à sua atividade biológica, tipicamente caracterizada por um anel de lactona e vários grupos funcionais que melhoram sua interação com a enzima alvo. Loxistatina foi estudado por suas propriedades farmacocinéticas, incluindo absorção, distribuição, metabolismo e excreção, que são essenciais para entender sua eficácia e perfil de segurança. Além disso, como outras estatinas, pode ter efeitos pleiotrópicos, potencialmente influenciando a inflamação e a função endotelial. No entanto, como qualquer agente farmacêutico, o uso de Loxistatina pode estar associado a efeitos colaterais, exigindo consideração cuidadosa em aplicações clínicas. Pesquisas adicionais continuam a explorar seu potencial terapêutico completo e mecanismos de ação.

Fórmula: C₁₇H₃₀N₂O₅

InChI: InChI=1S/C17H30N2O5/c1-6-23-17(22)14-13(24-14)16(21)19-12(9-11(4)5)15(20)18-8-7-10(2)3/h10-14H,6-9H2,1-5H3,(H,18,20)(H,19,21)/t12-,13-,14-/m0/s1

Chave InChI: InChIKey=SRVFFFJZQVENJC-IHRRRGAJSA-N

SMILES: C(N[C@H](C(NCCC(C)C)=O)CC(C)C)(=O)[C@@H]1[C@@H](C(OCC)=O)O1

Sinónimos:

• 2-Oxiranecarboxylic acid, 3-[[[(1S)-3-methyl-1-[[(3-methylbutyl)amino]carbonyl]butyl]amino]carbonyl]-, ethyl ester, (2S,3S)-
• Aloxistatin
• E 64c ethyl ester
• E-64d
• E64d
• E64d/pepstatin
• EST
• EST (pharmaceutical)
• Ep 453
• Loxistatin
• NSC 694281
• Oxiranecarboxylic acid, 3-[[[(1S)-3-methyl-1-[[(3-methylbutyl)amino]carbonyl]butyl]amino]carbonyl]-, ethyl ester, (2S,3S)-
• Oxiranecarboxylic acid, 3-[[[3-methyl-1-[[(3-methylbutyl)amino]carbonyl]butyl]amino]carbonyl]-, ethyl ester, [2S-[2α,3β(R*)]]-
• Pepstatin E64d
• ethyl (2S,3S)-3-({(2S)-4-methyl-1-[(3-methylbutyl)amino]-1-oxopentan-2-yl}carbamoyl)oxirane-2-carboxylate

L-trans-Epoxysuccinyl-Leu-3-methylbutylamide-ethyl ester

CAS: 88321-09-9

E64d (EST), a membrane permeable analog of E64c, was expected to be useful as an oral drug for muscular dystrophy due to its potent inhibitory activities against the cysteine proteinases involved in the myofibrillar protein degradation that occurs in this disease. E64d attenuates the effects of parathyroid hormone on osteoblasts in vitro. By inhibiting cathepsin B, a cysteine protease showing β-secretase activity, E64d could reduce brain Aβ and improve memory deficits in Alzheimer’s disease animal models.

Fórmula: C₁₇H₃₀N₂O₅

Pureza: > 99%

Cor e Forma: White

Peso molecular: 342.44

Ref: 01-4027911

2-Oxiranecarboxylic acid, 3-[[[(1S)-3-methyl-1-[[(3-methylbutyl)amino]carbonyl]butyl]amino]carbonyl]-, ethyl ester, (2S,3S)-

CAS: 88321-09-9

Fórmula: C₁₇H₃₀N₂O₅

Pureza: 98%

Cor e Forma: Solid

Peso molecular: 342.4305

Ref: IN-DA0048C1

Aloxistatin

CAS: 88321-09-9

Aloxistatin

Pureza: ≥98%

Peso molecular: 342.43g/mol

Ref: 54-BUP15070

E-64d [for Biochemical Research]

CAS: 88321-09-9

Fórmula: C₁₇H₃₀N₂O₅

Pureza: >95.0%(HPLC)

Cor e Forma: White to Almost white powder to crystal

Peso molecular: 342.44

Ref: 3B-E1337

E-64d protease inhibitor

CAS: 88321-09-9

Fórmula: C₁₇H₃₀N₂O₅

Pureza: ≥ 95.0%

Cor e Forma: White powder

Peso molecular: 342.43

Ref: 7W-GL9790

E-64d

CAS: 88321-09-9

E-64d

Fórmula: C₁₇H₃₀N₂O₅

Pureza: 98.8% (hplc) (Typical Value in Batch COA)

Cor e Forma: Powder

Peso molecular: 342.43g/mol

Ref: 54-BIE1005

Aloxistatin

CAS: 88321-09-9

Aloxistatin (E64d) inhibits cysteine proteases, blocks calpain in platelets, and prevents blood clotting.

Fórmula: C₁₇H₃₀N₂O₅

Pureza: 99.46% - 99.69%

Cor e Forma: Solid

Peso molecular: 342.43

Ref: TM-T6040

E-64d

Produto Controlado

CAS: 88321-09-9

Applications E-64d is an inhibitor of cathepsins B and L as well as a potential inhibitor of calpain. E-64d has been shown to inhibit lysosomal proteases. E-64d has been used in combination with Prepstatin A to interfere with autolysosomal digestion. E-64d displays neurovascular and neuronal protective effects after focal cerebral ischemia in rats.
References Wilcox, D. et al.: Biochem. J., 285, 495 (1992); McGowan, E.B. et al.: Biochem. Biophys. Res. Comm., 158, 432 (1989); Tsubokawa, T. et al.: J. Neurosci. Res., 84, 832 (2006);

Fórmula: C₁₇H₃₀N₂O₅

Cor e Forma: Neat

Peso molecular: 342.43

Ref: TR-E100500

(2S,3S)-trans-Epoxysuccinyl-L-leucylamido-3-methylbutane ethyl ester

CAS: 88321-09-9

Inhibitor of cathepsins

Fórmula: C₁₇H₃₀N₂O₅

Pureza: Min. 95%

Cor e Forma: Powder

Peso molecular: 342.43 g/mol

Ref: 3D-FE29623

E-64-d

CAS: 88321-09-9

E-64-d is a research tool that is used in cell biology, pharmacology, and biochemistry to study protein interactions. E-64-d is an activator, ligand, or receptor for ion channels and has been shown to inhibit the activity of high purity K+ channels. This peptide binds to the extracellular loop of voltage-gated potassium channels (Kv1.2) and inhibits the opening of these channels by blocking their access to ATP. E-64-d also binds to an antibody as a competitive inhibitor of the antigen binding site on the antibody.

Fórmula: C₁₇H₃₀N₂O₅

Pureza: Min. 95%

Peso molecular: 342.43 g/mol

Ref: 3D-IED-4321-V

L-TRANS-EPOXYSUCCINYL-LEU-3-METHYLBUTYLAMIDE-ETHYL ESTER

CAS: 88321-09-9

Pureza: 95.0%

Peso molecular: 342.4360046386719

Ref: 10-F475468