CAS 88937-61-5

Z-Arg-Arg-AMC

Descrição:

Z-Arg-Arg-AMC, também conhecido pelo seu número CAS 88937-61-5, é um substrato peptídico sintético comumente utilizado em pesquisas bioquímicas, particularmente em estudos envolvendo proteases e atividade enzimática. Este composto apresenta um grupo protetor Z (benzyloxycarbonilo) no resíduo de arginina N-terminal, o que melhora sua estabilidade e solubilidade. A presença de dois resíduos de arginina em sua estrutura o torna um substrato para várias enzimas, particularmente aquelas que clivam em aminoácidos básicos. O moiety AMC (7-amino-4-metilcumarina) serve como um repórter fluorescente, permitindo a quantificação da atividade enzimática por meio de medições de fluorescência. Z-Arg-Arg-AMC é frequentemente utilizado em ensaios para estudar a atividade proteolítica, fornecendo insights sobre a cinética enzimática e a especificidade do substrato. Suas características incluem alta solubilidade em soluções aquosas, estabilidade em condições fisiológicas e a capacidade de produzir um sinal fluorescente mensurável após a clivagem, tornando-o uma ferramenta valiosa na pesquisa em biologia molecular e bioquímica.

Fórmula: C₃₀H₃₉N₉O₆

InChI: InChI=1/C30H39N9O6/c1-18-15-25(40)45-24-16-20(11-12-21(18)24)37-22(9-5-13-35-28(31)32)26(41)39-27(42)23(10-6-14-36-29(33)34)38-30(43)44-17-19-7-3-2-4-8-19/h2-4,7-8,11-12,15-16,22-23,37H,5-6,9-10,13-14,17H2,1H3,(H,38,43)(H4,31,32,35)(H4,33,34,36)(H,39,41,42)/t22-,23-/m0/s1

Chave InChI: InChIKey=DLELKZFCVLJXKZ-GOTSBHOMSA-N

SMILES: CC=1C=2C(=CC(NC([C@@H](NC([C@@H](NC(OCC3=CC=CC=C3)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)=CC2)OC(=O)C1

Sinónimos:

• Z-Arg-Arg-AMC
• Benzyloxycarbonyl-L-arginyl-L-arginine 4-methylcoumaryl-7-amide
• 386: PN: US20220178935 SEQID: 1064 claimed sequence
• N2-[(Phenylmethoxy)carbonyl]-L-arginyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-L-argininamide
• L-Argininamide, N2-[(phenylmethoxy)carbonyl]-L-arginyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-
• Z-Arg-Arg-NHMec
• Z-ARG-ARG-MCA(HYDROCHLORIDE FORM)
• Z-ARG-ARG-MCA HYDROCHLORIDE
• BENZYLOXYCARBONYL-L-ARGINYL-L-ARGININE 4-METHYLCOUMARYL-7-AMIDE HYDROCHLORIDE
• benzyl N-[(2S)-5-(diaminomethylideneamino)-1-[[(2S)-5-(diaminomethylideneamino)-2-[(4-methyl-2-oxochromen-7-yl)amino]pentanoyl]amino]-1-oxopentan-2-yl]carbamate
• N-ALPHA-CBZ-ARG-ARG 7-AMIDO-4-METHYLCOUMARIN HYDROCHLORIDE
• Z-ARG-ARG-AMC HYDROCHLORIDE SALT
• benzyloxycarbonylarginyl-arginine 4-methylcoumarin-7-ylamide

Z-Arg-Arg-AMC

CAS: 88937-61-5

Z-RR-AMC, an excellent, specific substrate for cathepsin B, an enzyme found in secretory vesicles. Cathepsin B has been identified as a β-secretase, as such it is involved in β-amyloid production. Z-RR-AMC is a convenient fluorogenic substrate for stem bromelain, as it is scarcely affected by fruit bromelain.

Fórmula: C₃₀H₃₉N₉O₆

Pureza: > 98%

Cor e Forma: White Powder

Peso molecular: 621.7

Ref: 01-4004789

Z-Arg-Arg-AMC hydrochloride salt

CAS: 88937-61-5

Z-Arg-Arg-AMC hydrochloride salt is a versatile compound that acts as a catalyst and forms strong hydrogen bonds. It exhibits proteolytic activity and has been found to be effective in breaking down proteins. In addition, Z-Arg-Arg-AMC hydrochloride salt has been shown to possess neuroprotective properties, making it a potential candidate for the treatment of neurological disorders. It also demonstrates anthelmintic activity, which means it can be used to combat parasitic worm infections. Furthermore, this compound has antioxidant activity and can help reduce lipid peroxidation, protecting cells from oxidative damage. With its diverse range of characteristics, Z-Arg-Arg-AMC hydrochloride salt holds great promise in various research fields such as biochemistry and medicine.

Fórmula: C₃₀H₃₉N₉O₆·xHCl

Pureza: Min. 95%

Cor e Forma: Powder

Peso molecular: 621.69 g/mol

Ref: 3D-FA110491

Z-Arg-Arg-AMC

CAS: 88937-61-5

Z-Arg-Arg-AMC is an activator of the receptor tyrosine kinase (RTK) system. It binds to the extracellular domain of RTKs, such as epidermal growth factor receptors (EGFR) and fibroblast growth factor receptors (FGFR), and activates these receptors. This compound has been shown to activate EGFR and FGFR at low concentrations and inhibit their activation at high concentrations. Z-Arg-Arg-AMC has also been shown to be a potent inhibitor of protein interactions with a Kd of approximately 1 μM, which makes it a useful research tool for studying protein interactions.

Fórmula: C₃₀H₃₉N₉O₆

Pureza: Min. 95%

Peso molecular: 621.69 g/mol

Ref: 3D-MRR-3123-V