CAS 89226-75-5

Dihidrocloreto de manidipino

Descrição:

Dihidrocloreto de manidipino é um bloqueador de canais de cálcio utilizado principalmente no tratamento da hipertensão e certas condições cardiovasculares. Pertence à classe de antagonistas do cálcio dihidropiridínicos, que atuam inibindo a entrada de íons de cálcio através dos canais de cálcio tipo L no músculo liso vascular e no tecido cardíaco, levando à vasodilatação e à redução da pressão arterial. A substância é caracterizada por sua forma de sal diidratado, que melhora sua solubilidade e biodisponibilidade. Manidipina apresenta uma longa meia-vida, permitindo a dosagem uma vez ao dia, o que melhora a adesão do paciente. Seu perfil farmacológico inclui não apenas efeitos antihipertensivos, mas também benefícios potenciais na redução da demanda de oxigênio miocárdico. O composto é tipicamente administrado por via oral e pode estar associado a efeitos colaterais como edema periférico, dor de cabeça e rubor. Assim como qualquer medicamento, é essencial considerar contraindicações e interações com outros fármacos. No geral, Dihidrocloreto de manidipino é um agente terapêutico valioso no manejo da hipertensão e problemas cardiovasculares relacionados.

Fórmula: C₃₅H₄₀Cl₂N₄O₆

InChI: InChI=1/C35H38N4O6.ClH/c1-24-30(34(40)44-3)32(28-15-10-16-29(23-28)39(42)43)31(25(2)36-24)35(41)45-22-21-37-17-19-38(20-18-37)33(26-11-6-4-7-12-26)27-13-8-5-9-14-27;/h4-16,23,32-33,36H,17-22H2,1-3H3;1H

Chave InChI: InChIKey=JINNGBXKBDUGQT-UHFFFAOYSA-N

SMILES: C(OCCN1CCN(C(C2=CC=CC=C2)C3=CC=CC=C3)CC1)(=O)C=4C(C(C(OC)=O)=C(C)NC4C)C5=CC(N(=O)=O)=CC=C5.Cl

Sinónimos:

• 2-(4-Benzhydrylpiperazin-1-yl)ethyl methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate dihydrochloride
• 2-[4-(Diphenylmethyl)Piperazin-1-Yl]Ethyl Methyl 2,6-Dimethyl-4-(3-Nitrophenyl)-1,4-Dihydropyridine-3,5-Dicarboxylate Hydrochloride
• 2-[4-(Diphenylmethyl)piperazin-1-yl]ethyl methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate dihydrochloride
• 3,5-Pyridinedicarboxylic Acid, 1,4-Dihydro-2,6-Dimethyl-4-(3-Nitrophenyl)-, 2-[4-(Diphenylmethyl)-1-Piperazinyl]Ethyl Methyl Ester, Hydrochloride (1:2)
• 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 2-[4-(diphenylmethyl)-1-piperazinyl]ethyl methyl ester, dihydrochloride
• 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 3-[2-[4-(diphenylmethyl)-1-piperazinyl]ethyl] 5-methyl ester, hydrochloride (1:2)
• Calslot
• Cv 4093
• Franidipine hydrochloride
• Manidipine hydrochloride
• (±)-Manidipine dihydrochloride
• 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 2-[4-(diphenylmethyl)-1-piperazinyl]ethyl methyl ester hydrochloride
• 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 2-[4-(diphenylmethyl)-1-piperazinyl]ethyl methyl ester, dihydrochloride (9CI)
• CV-4093(2HCl)
• 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 2-[4-(diphenylmethyl)-1-piperazinyl]ethyl methyl ester hydrochloride
• franidipinehydrochloride
• cv-4093dihydrochlorde

Manidipine Dihydrochloride

CAS: 89226-50-6, 89226-75-5

Fórmula: C₃₅H₃₈N₄O₆·2HCl

Pureza: >98.0%(T)(HPLC)

Cor e Forma: White to Light yellow powder to crystal

Peso molecular: 683.63

Ref: 3B-M2225

Manidipine dihydrochloride

CAS: 89226-75-5

Calcium channel blocker

Fórmula: C₃₅H₃₈N₄O₆•2HCl

Peso molecular: 683.63

Ref: 02-J60496

Manidipine DiHCl

CAS: 89226-75-5

Fórmula: C₃₅H₃₈Cl₂N₄O₆

Pureza: 98%

Cor e Forma: Solid

Peso molecular: 683.6213

Ref: IN-DA0043GI

Manidipine dihydrochloride

CAS: 89226-75-5

Manidipine dihydrochloride (Manidipine 2HCl) is a potent calcium channel blocker for Ca2+ current(IC50=2.6 nM).

Fórmula: C₃₅H₄₀Cl₂N₄O₆

Pureza: 99.76% - 99.86%

Cor e Forma: Solid

Peso molecular: 683.62

Ref: TM-T0193

Manidipine Dihydrochloride

CAS: 89226-75-5

Manidipine Dihydrochloride

Pureza: 99%

Peso molecular: 683.62g/mol

Ref: 54-OR1013718

Manidipine DiHCl

CAS: 89226-75-5

Fórmula: C₃₅H₃₈N₄O₆·2HCl

Cor e Forma: Off-White Solid

Peso molecular: 610.71 2*36.46

Ref: 4Z-M-2610

Manidipine dihydrochloride

CAS: 89226-75-5

Manidipine dihydrochloride

Pureza: ≥98%

Peso molecular: 683.62g/mol

Ref: 54-BUP14828

Manidipine dihydrochloride

CAS: 89226-75-5

Fórmula: C₃₅H₃₈N₄O₆·2HCl

Pureza: ≥ 98.0%

Cor e Forma: White to pale yellow powder or crystals

Peso molecular: 683.63

Ref: 7W-GP1065

Manidipine Dihydrochloride

Produto Controlado

CAS: 89226-75-5

Applications Manidipine Dihydrochloride is a metabolite of Manidipine (M164000), a dihydropyridine calcium channel blocker that exhibits antihypertensive properties.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Meguro, K., et al.: Chem. Pharm. Bull., 33, 3787 (1985), Mizuno, K., et al.: Curr. Ther. Res., 52, 248 (1992); Hosaka, S., et al.: Chem. Pharma. Bulletin., 55, 793 (2007);

Fórmula: C₃₅H₃₈N₄O₆·2ClH

Cor e Forma: Neat

Peso molecular: 683.6213

Ref: TR-M164015

Manidipine dihydrochloride

CAS: 89226-75-5

Manidipine is an antagonist of L-and T-type calcium channels that are present on smooth muscle cells. Manidipine is clinically used in hypertensive patients to achieve a significant peripheral vasodilation without an associated cardiodepression. In 2020, manidipine was identified as a potential drug in the treatment of COVID-19.

Fórmula: C₃₅H₃₈N₄O₆•(HCl)₂

Pureza: Min. 95%

Cor e Forma: Powder

Peso molecular: 683.62 g/mol

Ref: 3D-FM65072