CAS 9002-96-4

succinato de polietilenoglicol de α-tocoferilo

Descrição:

succinato de polietilenoglicol de α-tocoferilo, comumente conhecido como TPGS, é um derivado sintético da vitamina E (α-tocoferol) amplamente utilizado em formulações farmacêuticas e cosméticas. É caracterizado por sua natureza anfifílica, que lhe permite funcionar como um surfactante e solubilizante, melhorando a biodisponibilidade de medicamentos pouco solúveis. O TPGS é conhecido por sua capacidade de melhorar a estabilidade das formulações e também pode atuar como um antioxidante devido à presença da parte de tocoferol. Seu componente de polietileno glicol (PEG) contribui para sua hidrofobicidade, facilitando a formação de micelas e melhorando os sistemas de entrega de medicamentos. Além disso, o TPGS é reconhecido por sua biocompatibilidade e baixa toxicidade, tornando-o adequado para várias aplicações, incluindo entrega de medicamentos orais, parenterais e tópicos. Suas propriedades únicas permitem que seja utilizado em uma variedade de indústrias, desde farmacêuticas até cosméticas, onde pode melhorar o desempenho e a eficácia do produto.

Fórmula: (C₂H₄O)nC₃₃H₅₄O₅

InChI: InChI=1S/C35H58O6/c1-24(2)12-9-13-25(3)14-10-15-26(4)16-11-20-35(8)21-19-30-29(7)33(27(5)28(6)34(30)41-35)40-32(38)18-17-31(37)39-23-22-36/h24-26,36H,9-23H2,1-8H3

Chave InChI: InChIKey=AOBORMOPSGHCAX-UHFFFAOYSA-N

SMILES: CC(C)CCCC(C)CCCC(C)CCCC1(C)CCc2c(C)c(c(C)c(C)c2O1)OC(=O)CCC(=O)OCCO

Sinónimos:

• 2-hydroxyethyl 2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-3,4-dihydro-2H-chromen-6-yl butanedioate
• <span class="text-smallcaps">D</span>-α-Tocopherol acid polyethylene glycol 1000 succinate
• <span class="text-smallcaps">D</span>-α-Tocopherol polyethylene glycol 1000 succinate
• <span class="text-smallcaps">D</span>-α-Tocopheryl polyethylene glycol succinate
• Eastman Vitamin ETPGS
• Ethoxylated vitamin E succinate
• Kolliphor TPGS
• Mono[2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-6-chromanyl] succinate, polyoxyethylene ether
• Poly(oxy-1,2-ethanediyl), α-[4-[[(2R)-3,4-dihydro-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-2H-1-benzopyran-6-yl]oxy]-1,4-dioxobutyl]-ω-hydroxy-
• Poly(oxy-1,2-ethanediyl), α-[4-[[3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-yl]oxy]-1,4-dioxobutyl]-ω-hydroxy-, [2R-[2R*(4R*,8R*)]]-
• Polyethylene glycol vitamin E succinate
• Speziol TPGS Pharma
• Tocophersolan
• Tpgs 1000
• Tpgs 1500
• Tpgs 400-1000
• Tpgs-Ve
• Ve-Tpgs 1000
• Vedrop
• VitE-TPGS
• Vitamin E-TPGS
• d-α-Tocopheryl poly(ethylene glycol) 1000 succinate
• d-α-Tocopheryl polyethylene glycol succinate
• α-Tocopherol polyethylene glycol succinate
• α-Tocopheryl polyethylene glycol succinate
• D-α-Tocopherol polyethylene glycol 1000 succinate

D-α-Tocopherol polyethylene glycol 1000 succinate, USP/NF grade

CAS: 9002-96-4

Cor e Forma: White to light-brown powder or waxy solid

Ref: 7W-GK2110

D-α-Tocopherol polyethylene glycol succinate

CAS: 9002-96-4

Pureza: ≥ 25.0% (D-Alpha Tocopherol)

Cor e Forma: White to light-brown powder or waxy solid

Peso molecular: -

Ref: 7W-GK2339

α-Tocopherol Polyethylene Glycol Succinate

CAS: 9002-96-4

Cor e Forma: White or Colorless to Yellow powder to lump to clear liquid

Ref: 3B-T3118

Tocofersolan

CAS: 9002-96-4

Tocofersolan (TPGS) treats vitamin E deficiency in pediatric digestive malabsorption.

Fórmula: C₃₉H₆₆O₈

Pureza: ≥98%

Cor e Forma: Clear Colorless Solid

Peso molecular: 662.94

Ref: TM-T4994

Tocofersolan

CAS: 9002-96-4

Applications Tocofersolan is a polyethylene glycol derivative of α-Tocopherol (T526125). Tocofersolan is a synthetic water-soluble vitamin E unlike its natural counterpart which are fat soluble. Tocofersolan is used in pediatrics in the treatment vitamin E-deficient cholestatic children. Tocofersolan has potential application as a absorption enhancer in drug delivery systems. Typical batch, n = 21
References Socha, P. et al.: J. Pediatric Gastroenterol. Nutr., 24, 189 (1997); Chang, T. et al.: Clin. Pharmacol. Therap., 59, 297 (1996); Wu, S.H.W. et al.: Pharmac. Technol., 23, 52 (1999);

Fórmula: C₃₃H₅₄O₅(C₂H₄O)n

Cor e Forma: Neat

Peso molecular: 530.78 + (44.05)n

Ref: TR-T526075

α-Tocopherol Polyethylene Glycol Succinate

CAS: 9002-96-4

Fórmula: C₃₃H₅₄O₅(C₂H₄O)n

Peso molecular: 530.79)( 44.05)n

Ref: ST-EA-CP-T94007

D-alpha-Tocopheryl polyethylene glycol succinate

CAS: 9002-96-4

D-alpha-Tocopheryl polyethylene glycol succinate (TPGS) is a vitamin E derivative that is active in inhibiting chronic myeloid leukemia. TPGS has been shown to be effective against the resistant K562 cells and may be used as a treatment for chronic myeloid leukemia. This drug binds to the enzyme urokinase-type plasminogen activator, which is essential for cancer cell migration and invasion of tumor tissue. It also inhibits tyrosine kinase, which plays an important role in the development of cancer cells by regulating cellular growth and proliferation. TPGS has been shown to have low bioavailability in humans and is not detectable in plasma after oral administration.

Fórmula: C₃₃H₅₄O₅•(C₂H₄O)n

Pureza: Min. 25.0%

Cor e Forma: White Slightly Brown Solidified Mass

Ref: 3D-FT40328

Poly(oxy-1,2-ethanediyl),a-[4-[[(2R)-3,4-dihydro-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-2H-1-benzopyran-6-yl]oxy]-1,4-dioxobutyl]-w-hydroxy-

CAS: 9002-96-4

Fórmula: C₃₉H₆₆O₈

Cor e Forma: Solid

Peso molecular: 662.9365

Ref: IN-DA00IFZ3