CAS 90332-63-1
:7-Xilosil-10-desacetiltaxol
Descrição:
7-Xilosil-10-desacetiltaxol, identificado pelo seu número CAS 90332-63-1, é um composto químico derivado da família dos taxanos, conhecido por seu papel significativo no tratamento do câncer, particularmente na formulação de agentes quimioterápicos como o paclitaxel. Este composto apresenta um grupo de açúcar xilosílico ligado à estrutura do taxano, o que pode influenciar sua solubilidade, estabilidade e atividade biológica. A presença do grupo desacetilado sugere que pode exibir propriedades farmacológicas diferentes em comparação com suas contrapartes acetiladas. Em geral, os taxanos são caracterizados por sua capacidade de inibir a despolimerização de microtúbulos, interrompendo assim a divisão celular normal, que é um mecanismo crítico na terapia do câncer. As características específicas de 7-Xilosil-10-desacetiltaxol, incluindo seu peso molecular, solubilidade e atividade biológica, seriam essenciais para entender suas potenciais aplicações terapêuticas e eficácia. Estudos adicionais seriam necessários para elucidar sua farmacocinética, toxicidade e papel geral na química medicinal.
Fórmula:C50H57NO17
InChI:InChI=1S/C50H57NO17/c1-25-31(65-45(61)38(56)35(27-15-9-6-10-16-27)51-43(59)28-17-11-7-12-18-28)22-50(62)42(67-44(60)29-19-13-8-14-20-29)40-48(5,41(58)37(55)34(25)47(50,3)4)32(21-33-49(40,24-64-33)68-26(2)52)66-46-39(57)36(54)30(53)23-63-46/h6-20,30-33,35-40,42,46,53-57,62H,21-24H2,1-5H3,(H,51,59)/t30-,31+,32+,33-,35+,36+,37-,38-,39-,40+,42+,46+,48-,49+,50-/m1/s1
Chave InChI:InChIKey=ORKLEZFXASNLFJ-DYLQFHMVSA-N
SMILES:O(C(C)=O)[C@]12[C@@]3([C@@](C)([C@@H](O[C@H]4[C@H](O)[C@@H](O)[C@H](O)CO4)C[C@]1(OC2)[H])C(=O)[C@H](O)C=5C(C)(C)[C@](O)([C@H]3OC(=O)C6=CC=CC=C6)C[C@H](OC([C@@H]([C@@H](NC(=O)C7=CC=CC=C7)C8=CC=CC=C8)O)=O)C5C)[H]
Sinónimos:- 10-Deacetyl-7-xylosylpaclitaxel
- 10-Deacetyl-7-xylosyltaxol
- 10-Deacetylpaclitaxel 7-xyloside
- 10-Deacetyltaxol 7-xyloside
- 7,11-Methano-1H-cyclodeca[3,4]benz[1,2-b]oxete, benzenepropanoic acid deriv.
- 7-Xylosyl-10-deacetylpaclitaxel
- 7β-Xylosyl-10-deacetyltaxol
- Benzenepropanoic acid, β-(benzoylamino)-α-hydroxy-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-6,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-4-(β-<span class="text-smallcaps">D</span>-xylopyranosyloxy)-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, (αR,βS)-
- Benzenepropanoic acid, β-(benzoylamino)-α-hydroxy-, 12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-6,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-4-(β-<span class="text-smallcaps">D</span>-xylopyranosyloxy)-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, [2aR-[2aα,4β,4aβ,6β,9α(αR*,βS*),11α,12α,12aα,12bα]]-
- b-(Benzoylamino)-a-hydroxy-benzenepropanoic acid [2aR-[2aa,4b,4ab,6b,9a(aR*,bS*),11a,12a,12aa,12ba]]-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-6,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-4-(b-D-xylopyranosyloxy)-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester
- Benzenepropanoic acid, β-(benzoylamino)-α-hydroxy-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-6,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-4-(β-D-xylopyranosyloxy)-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, (αR,βS)-
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11 produtos.
Benzenepropanoic acid, b-(benzoylamino)-a-hydroxy-,(2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-6,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-4-(b-D-xylopyranosyloxy)-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, (aR,bS)-
CAS:Fórmula:C50H57NO17Pureza:95%Cor e Forma:SolidPeso molecular:943.984110-Deacetyl-7-xylosyl paclitaxel
CAS:10-Deacetyl-7-xylosyl paclitaxelPureza:≥95%Peso molecular:943.98g/mol10-Deacetyl-7-Xylosylpaclitaxel
CAS:Fórmula:C50H57NO17Cor e Forma:White To Off-White SolidPeso molecular:944.0010-Deacetyl-7-xylosyl paclitaxel
CAS:10-Deacetyl-7-xylosyl paclitaxel has long been used in Chinese clinics to treat cancer, it may target mitochondrial permeability transition pore (mPTP).Fórmula:C50H57NO17Pureza:95%~99%Peso molecular:943.99610-Deacetyl-7-xylosyl paclitaxel
CAS:10-Deacetyl-7-xylosyl paclitaxel (7-Xylosyl-10-deacetyltaxol) is a Paclitaxel derivative with improved pharmacological features and higher water solubility.Fórmula:C50H57NO17Pureza:99.76% - ≥95%Cor e Forma:SolidPeso molecular:943.9810-Deacetyl-7-xylosyl Paclitaxel (62%)
CAS:Produto ControladoImpurity Paclitaxel - In House Impurity
Stability Hygroscopic
Applications A metabolite of Paclitaxel (P132500). Paclitaxel - In House Impurity.
References Gut, I., et al.: Xenobiotica, 36, 772 ( 2006), Zhang, J., et al.: Drug Metab. Dispos., 36, 418 (2008), Li, S., et al.: J. Pharm. Biomed. Anal., 49, 81, (2009),Fórmula:C50H57NO17Pureza:62%Cor e Forma:NeatPeso molecular:943.987-Xylosyl-10-deacetyltaxol
CAS:7-Xylosyl-10-deacetyltaxol is a plant chemical that is found in the needles of the Taxus cuspidata tree. This compound has been shown to inhibit prostate cancer cells and has been clinically used as an adjuvant agent for cancer treatment. 7-Xylosyl-10-deacetyltaxol binds to prostate cancer cells and inhibits their growth, which may be due to its ability to inhibit cell cycle progression at the G2/M phase transition. It also has a strong inhibitory effect on test samples from human prostate cancer cells. In addition, it inhibits enzyme activities that are involved in the biosynthesis of membrane lipids, such as phospholipase A2, arachidonate 12-lipoxygenase, and cyclooxygenase 2. 7-Xylosyl-10-deacetyltaxol also inhibits enzyme activities in cell culture that are involved in the synthesis of carbon
Fórmula:C50H57NO17Pureza:Min. 95%Peso molecular:943.98 g/mol
