CAS 9076-44-2

Quimostatina

Descrição:

Quimostatina é um inibidor potente e seletivo de proteases de serina, direcionado particularmente à quimotripsina e enzimas relacionadas. É um produto natural derivado da fermentação de certos actinobactérias, especificamente espécies de Streptomyces. Quimostatina exibe uma estrutura única que lhe permite se ligar efetivamente ao sítio ativo das proteases de serina, impedindo assim o acesso ao substrato e inibindo a atividade enzimática. Essa característica o torna uma ferramenta valiosa na pesquisa bioquímica para estudar as funções e mecanismos das proteases. Além disso, Quimostatina tem sido investigado por suas potenciais aplicações terapêuticas, particularmente na pesquisa do câncer, devido à sua capacidade de modular os processos proteolíticos envolvidos na progressão tumoral e metástase. O composto é tipicamente utilizado em ambientes de laboratório, e sua eficácia pode variar com base na protease específica que está sendo estudada. Assim como muitos inibidores de proteases, a consideração cuidadosa da concentração e das condições experimentais é essencial para resultados ótimos em aplicações de pesquisa.

Fórmula: Unspecified

InChI: InChI=1/2C31H41N7O6.C30H39N7O6/c1-19(2)15-24(27(40)34-22(18-39)16-20-9-5-3-6-10-20)35-28(41)26(23-13-14-33-30(32)36-23)38-31(44)37-25(29(42)43)17-21-11-7-4-8-12-21;1-3-19(2)25(27(40)34-22(18-39)16-20-10-6-4-7-11-20)37-28(41)26(23-14-15-33-30(32)35-23)38-31(44)36-24(29(42)43)17-21-12-8-5-9-13-21;1-18(2)24(26(39)33-21(17-38)15-19-9-5-3-6-10-19)36-27(40)25(22-13-14-32-29(31)34-22)37-30(43)35-23(28(41)42)16-20-11-7-4-8-12-20/h3-12,18-19,22-26H,13-17H2,1-2H3,(H,34,40)(H,35,41)(H,42,43)(H3,32,33,36)(H2,37,38,44);4-13,18-19,22-26H,3,14-17H2,1-2H3,(H,34,40)(H,37,41)(H,42,43)(H3,32,33,35)(H2,36,38,44);3-12,17-18,21-25H,13-16H2,1-2H3,(H,33,39)(H,36,40)(H,41,42)(H3,31,32,34)(H2,35,37,43)/t22-,23?,24-,25-,26-;19-,22-,23?,24-,25-,26-;21-,22?,23-,24-,25-/m000/s1

SMILES: CC(C)C[C@@H](C(=N[C@@H](Cc1ccccc1)C=O)O)N=C([C@H](C1CCNC(=N)N1)NC(=N[C@@H](Cc1ccccc1)C(=O)O)O)O.CC[C@H](C)[C@@H](C(=N[C@@H](Cc1ccccc1)C=O)O)N=C([C@H](C1CCNC(=N)N1)NC(=N[C@@H](Cc1ccccc1)C(=O)O)O)O.CC(C)[C@@H](C(=N[C@@H](Cc1ccccc1)C=O)O)N=C([C@H](C1CCNC(=N)N1)NC(=N[C@@H](Cc1ccccc1)C(=O)O)O)O

Sinónimos:

• Chymostatin
• N-{[(1S)-1-(2-amino-3,4,5,6-tetrahydropyrimidin-4-yl)-2-{[(2S)-4-methyl-1-oxo-1-{[(2S)-1-oxo-3-phenylpropan-2-yl]amino}pentan-2-yl]amino}-2-oxoethyl]carbamoyl}-L-phenylalanine
• (2S)-2-[[(1S)-1-(2-amino-3,4,5,6-tetrahydropyrimidin-4-yl)-2-[[(1S)-1-[[(1S)-1-benzyl-2-oxo-ethyl]carbamoyl]-3-methyl-butyl]amino]-2-oxo-ethyl]carbamoylamino]-3-phenyl-propanoic acid
• (2S)-2-[[(1S)-1-(2-amino-3,4,5,6-tetrahydropyrimidin-4-yl)-2-[[(1S,2S)-1-[[(1S)-1-benzyl-2-oxo-ethyl]carbamoyl]-2-methyl-butyl]amino]-2-oxo-ethyl]carbamoylamino]-3-phenyl-propanoic acid
• (2S)-2-[[(1S)-1-(2-amino-3,4,5,6-tetrahydropyrimidin-4-yl)-2-[[(1S)-1-[[(1S)-1-benzyl-2-oxo-ethyl]carbamoyl]-2-methyl-propyl]amino]-2-oxo-ethyl]carbamoylamino]-3-phenyl-propanoic acid

Chymostatin

CAS: 9076-44-2

For research use

Cor e Forma: White to off-white, Powder

Ref: 02-J63275

Chymostatin (microbial product)

CAS: 9076-44-2

The microbial product is a mixture of the chymostatins A, B, and C. It inhibits most cysteine proteases, especially chymotrypsin. Chymostatin is often applied for inhibiting chymase.

Cor e Forma: White Powder

Ref: 01-4030514

Chymostatin

CAS: 9076-44-2

Fórmula: C₃₁H₄₁N₇O₆

Peso molecular: 604.90

Ref: 7W-GP4687

Chymostatin

CAS: 9076-44-2

Chymostatin is a protein that inhibits the polymerase chain reaction (PCR) by binding to the DNA polymerase. It has been shown to have a hypoglycemic effect in mice with myocardial infarcts and can also induce apoptosis in inflammatory lesions. Chymostatin binds to intracellular targets, such as cell factor and pro-apoptotic protein, which are involved in energy metabolism and inflammatory lesion. The inhibition of these targets may be due to its chemical biology properties, which include the formation of disulfide bonds and basic proteins. Chymostatin is not active against bacterial cells but can inhibit enzyme activities in mammalian cells.

Fórmula: C₃₁H₄₂N₆O₇

Pureza: Min. 95%

Peso molecular: 610.71 g/mol

Ref: 3D-ICY-4063

Chymostatin

CAS: 9076-44-2

Inhibitor of chymotrypsin

Fórmula: C₃₁H₄₁N₇O₆

Cor e Forma: White To Yellowish Solid

Peso molecular: 607.7 g/mol

Ref: 3D-FC29634

Chymostatin (0.5 mg vial)

CAS: 9076-44-2

Chymostatin is a protein-based inhibitor that binds to the receptor site of amyloid beta peptides, preventing them from aggregating and thereby inhibiting the formation of amyloid plaques. It has been shown that chymostatin inhibits ion channels, ligand-gated channels, and voltage-gated channels. Chymostatin is a high purity product with an average purity of 99% by HPLC analysis. It is also available in a variety of concentrations (0.5 mg vial).

Fórmula: C₃₁H₄₂N₆O₇

Pureza: Min. 95%

Peso molecular: 610.72 g/mol

Ref: 3D-ICY-4063-V

Chymostatin

CAS: 9076-44-2

Fórmula: C₃₁H₄₁N₇O₆

Pureza: 95%

Cor e Forma: Solid

Peso molecular: 607.7005400000002

Ref: IN-DA00ILR4