CAS 90954-53-3

peptídeo relacionado ao gene da calcitonina humano

Descrição:

O peptídeo relacionado ao gene da calcitonina (CGRP) é um neuropeptídeo que desempenha um papel significativo em vários processos fisiológicos, particularmente no sistema nervoso e na regulação cardiovascular. É derivado do gene da calcitonina e está principalmente envolvido na vasodilatação e na transmissão de sinais de dor. O CGRP é composto por uma sequência de aminoácidos, tornando-se um peptídeo, e existe em duas isoformas: alfa e beta, sendo a forma alfa predominante em humanos. O peptídeo é conhecido por seus potentes efeitos vasodilatadores, que contribuem para seu papel na fisiopatologia da enxaqueca. O CGRP também está implicado em respostas inflamatórias e tem sido estudado por suas potenciais aplicações terapêuticas em condições como enxaquecas e outros distúrbios da dor. Sua atividade biológica é mediada através de receptores específicos, conhecidos como receptores de CGRP, que são receptores acoplados a proteínas G. O número CAS 90954-53-3 identifica exclusivamente essa substância em bancos de dados químicos, facilitando a pesquisa e o desenvolvimento em farmacologia e bioquímica.

Fórmula: C₁₆₃H₂₆₇N₅₁O₄₉S₂

InChI: InChI=1/C163H269N51O49S2/c1-73(2)52-97(186-116(226)65-179-131(233)82(18)183-139(241)98(53-74(3)4)193-137(239)94(44-35-49-176-162(171)172)188-142(244)101(57-91-62-175-72-182-91)199-159(261)128(88(24)221)213-156(258)123(79(13)14)207-151(253)110(71-265)204-160(262)126(86(22)219)210-133(235)84(20)185-157(259)125(85(21)218)211-147(249)105(61-119(229)230)198-150(252)109(70-264)203-130(232)81(17)166)140(242)194-99(54-75(5)6)141(243)202-108(69-217)149(251)190-95(45-36-50-177-163(173)174)138(240)201-106(67-215)134(236)180-63-115(225)178-64-118(228)205-121(77(9)10)155(257)208-122(78(11)12)154(256)191-93(43-32-34-48-165)136(238)196-102(58-112(167)222)144(246)197-103(59-113(168)223)143(245)195-100(56-90-40-29-26-30-41-90)145(247)209-124(80(15)16)161(263)214-51-37-46-111(214)152(254)212-127(87(23)220)158(260)200-104(60-114(169)224)146(248)206-120(76(7)8)153(255)181-66-117(227)187-107(68-216)148(250)189-92(42-31-33-47-164)135(237)184-83(19)132(234)192-96(129(170)231)55-89-38-27-25-28-39-89/h25-30,38-41,62,72-88,92-111,120-128,215-221,264-265H,31-37,42-61,63-71,164-166H2,1-24H3,(H2,167,222)(H2,168,223)(H2,169,224)(H2,170,231)(H,175,182)(H,178,225)(H,179,233)(H,180,236)(H,181,255)(H,183,241)(H,184,237)(H,185,259)(H,186,226)(H,187,227)(H,188,244)(H,189,250)(H,190,251)(H,191,256)(H,192,234)(H,193,239)(H,194,242)(H,195,245)(H,196,238)(H,197,246)(H,198,252)(H,199,261)(H,200,260)(H,201,240)(H,202,243)(H,203,232)(H,204,262)(H,205,228)(H,206,248)(H,207,253)(H,208,257)(H,209,247)(H,210,235)(H,211,249)(H,212,254)(H,213,258)(H,229,230)(H4,171,172,176)(H4,173,174,177)/t81-,82-,83-,84-,85+,86+,87+,88+,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,120-,121-,122-,123-,124-,125-,126-,127-,128-/m0/s1

Sinónimos:

• Calcitonin Gene-Related Peptide-I, Human
• Ala-Cys-Asp-Thr-Ala-Thr-Cys-Val-Thr-His-Arg-Leu-Ala-Gly-Leu-Leu-Ser-Arg-Ser-Gly-Gly-Val-Val-Lys-Asn-Asn-Phe-Val-Pro-Thr-Asn-Val-Gly-Ser-Lys-Ala-Phe-Nh2

Calcitonin Gene Related Peptide, Human

CAS: 90954-53-3

For cellular and molecular biology applications

Fórmula: C₁₆₃H₂₆₇N₅₁O₄₉S₂

Peso molecular: 3789.3

Ref: 02-J65667

α-CGRP (human)

CAS: 90954-53-3

Bachem ID: 4013281.

Fórmula: C₁₆₃H₂₆₇N₅₁O₄₉S₂

Pureza: 97.62%

Cor e Forma: White

Peso molecular: 3789.36

Ref: 01-4013281

α-CGRP(human)

CAS: 90954-53-3

Endogenous calcitonin gene-related peptide receptor (CGRP) agonist.

Fórmula: C₁₆₃H₂₆₇N₅₁O₄₉S₂

Pureza: 98%

Cor e Forma: Solid

Peso molecular: 3789.33

Ref: TM-TP2044

CGRP (Human)

CAS: 90954-53-3

Human CGRP with a disulfide bond between Cys2-Cys7 and available as a 0.1mg vial. CGRP (calcitonin gene-related peptide) is a 37-amino acid neuropeptide that is found in humans and is widely distributed in the nervous system, particularly in sensory neurons, and is involved in the regulation of vascular tone, blood flow, pain perception, and inflammation. It is a potent vasodilator and has been implicated in the pathophysiology of several vascular disorders, including migraine headaches, cluster headaches, and hypertension.
In addition to its vascular effects, human CGRP also has neuroprotective properties and has been investigated as a potential therapeutic agent for various neurological disorders, such as Alzheimer's disease and Parkinson's disease.
Human CGRP has been extensively studied as a research tool to investigate its physiological and pathological roles in various tissues and diseases. It has also been targeted by pharmacological agents, such as CGRP antagonists and antibodies, for the treatment of migraine headaches and other conditions associated with CGRP dysfunction.

Fórmula: C₁₆₃H₂₆₇N₅₁O₄₉S₂

Pureza: Min. 95%

Peso molecular: 3,789.3 g/mol

Ref: 3D-PCG-4160-S

CGRP (Human)

CAS: 90954-53-3

CGRP (calcitonin gene-related peptide) is a 37-amino acid neuropeptide that is found in humans and is widely distributed in the nervous system, particularly in sensory neurons, and is involved in the regulation of vascular tone, blood flow, pain perception, and inflammation. It is a potent vasodilator and has been implicated in the pathophysiology of several vascular disorders, including migraine headaches, cluster headaches, and hypertension.
In addition to its vascular effects, human CGRP also has neuroprotective properties and has been investigated as a potential therapeutic agent for various neurological disorders, such as Alzheimer's disease and Parkinson's disease.
Human CGRP has been extensively studied as a research tool to investigate its physiological and pathological roles in various tissues and diseases. It has also been targeted by pharmacological agents, such as CGRP antagonists and antibodies, for the treatment of migraine headaches and other conditions associated with CGRP dysfunction.
This product is available as a 0.5mg vial.

Fórmula: C₁₆₃H₂₆₇N₅₁O₄₉S₂

Pureza: Min. 95%

Peso molecular: 3,789.3 g/mol

Ref: 3D-PCG-4160-V