CAS 91224-37-2

(D-arg1,D-trp7,9,leu11)-substância P*acetato

Descrição:

(D-arg1,D-trp7,9,leu11)-substância P*acetato, com o número CAS 91224-37-2, é um análogo sintético da substância P, um neuropeptídeo envolvido em vários processos fisiológicos, incluindo percepção da dor e inflamação. Este composto é caracterizado por sua sequência de aminoácidos modificada, que inclui D-arginina na posição 1, D-triptofano nas posições 7 e 9, e leucina na posição 11, aumentando sua estabilidade e afinidade de ligação aos receptores em comparação com o peptídeo natural. O componente de acetato indica que o composto está em sua forma de sal de acetato, o que pode influenciar sua solubilidade e biodisponibilidade. Tipicamente, tais análogos são estudados por suas potenciais aplicações terapêuticas, particularmente no manejo da dor e na neurobiologia, devido à sua capacidade de interagir com os receptores de neuroquinina. As modificações estruturais visam melhorar as propriedades farmacológicas enquanto reduzem a suscetibilidade à degradação enzimática. No geral, este composto representa um interesse significativo em química medicinal e farmacologia para o desenvolvimento de novos tratamentos direcionados a vias de neuropeptídeos.

Fórmula: C₇₅H₁₀₈N₂₀O₁₃

InChI: InChI=1/C75H108N20O13/c1-42(2)35-55(64(80)98)89-67(101)56(36-43(3)4)90-69(103)59(39-46-41-85-51-23-11-9-20-48(46)51)93-68(102)57(37-44-17-6-5-7-18-44)91-70(104)58(38-45-40-84-50-22-10-8-19-47(45)50)92-66(100)52(27-29-62(78)96)86-65(99)53(28-30-63(79)97)87-71(105)61-26-16-34-95(61)74(108)54(24-12-13-31-76)88-72(106)60-25-15-33-94(60)73(107)49(77)21-14-32-83-75(81)82/h5-11,17-20,22-23,40-43,49,52-61,84-85H,12-16,21,24-39,76-77H2,1-4H3,(H2,78,96)(H2,79,97)(H2,80,98)(H,86,99)(H,87,105)(H,88,106)(H,89,101)(H,90,103)(H,91,104)(H,92,100)(H,93,102)(H4,81,82,83)/t49-,52?,53+,54+,55+,56?,57+,58-,59-,60?,61?/m1/s1

Sinónimos:

• (D-Arg1,D-Trp79,Leu11)-Substance P
• H-D-Arg-Pro-Lys-Pro-Gln-Gln-D-Trp-Phe-D-Trp-Leu-Leu-NH2
• D-Arg-Pro-Lys-Pro-Gln-Gln-D-Trp-Phe-D-Trp-Leu-Leu-Nh2 Hydrochloride

(D-Arg¹,D-Trp⁷·⁹,Leu¹¹)-Substance P

CAS: 91224-37-2

Spantide I, a high potency substance P antagonist with a weak spasmogenic and a poor histamine releasing effect.

Fórmula: C₇₅H₁₀₈N₂₀O₁₃

Pureza: 95.2%

Cor e Forma: Beige Powder

Peso molecular: 1497.81

Ref: 01-4004691

[D-Arg1, D-Trp7,9, Leu11]-Substance P

CAS: 91224-37-2

Fórmula: C₇₅H₁₀₈N₂₀O₁₃

Peso molecular: 1497.79

Ref: 7W-GL0691

Spantide I

CAS: 91224-37-2

Spantide antagonizes both bombesin & substance P. It is also tachykinin receptor antagonist.

Fórmula: C₇₅H₁₀₈N₂₀O₁₃

Pureza: 98%

Cor e Forma: Solid

Peso molecular: 1497.79

Ref: TM-T20413

[D-Arg1,D-Trp7,9,Leu11]-Substance P

CAS: 91224-37-2

This product is a Substance P antagonist in the Hydrochloride salt from and as a 0.5mg vial. Substance P is a neuropeptide that acts as a neurotransmitter and neuromodulator. It is best known for its role in nociception or pain perception. Substance P is also involved in other biological processes such as the regulation of gastrointestinal motility and the inflammatory response. As a tachykinin neuropeptide, substance P acts through binding to its specific neurokinin 1 receptor (NK-1R). NK-1R is present in neurons and on glial cell types. Substance P is also involved in: increased inflammation in the lungs, gastrointestinal tract and the skin and neuroinflammation. Interestingly the levels of Substance P are raised in inflammatory bowel diseases and through its involvement in cytokine release, it contributes to asthma pathology. These diverse selection of functions makes substance P a target for therapeutic research.

Fórmula: C₇₅H₁₀₈N₂₀O₁₃

Pureza: Min. 95%

Peso molecular: 1,497.8 g/mol

Ref: 3D-PSP-4173-V

(D-Arg1,D-Trp7·9,Leu11)-Substance P

CAS: 91224-37-2

Substance P is a neuropeptide that is involved in the transmission of pain signals from the nerves to the brain. It also has been implicated in inflammatory and autoimmune diseases. Substance P is a potent agonist of the neurokinin-1 receptor, which causes an increase in intracellular calcium ion levels, leading to neuronal excitation. The release of substance P from nerve fibers can be blocked by administration of an analog (e.g., N-acetyl-D-Arg1,D-Trp7·9,Leu11)-substance P H-D-Arg-Pro-Lys-Pro-Gln-Gln-D-Trp-Phe-D-Trp-Leu -Leu -NH2). This compound blocks the activation of substance P receptors with high affinity and specificity.

Fórmula: C₇₅H₁₀₈N₂₀O₁₃

Pureza: Min. 95%

Peso molecular: 1,497.79 g/mol

Ref: 3D-FA108555